Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Mei-Kwan Yau"'
Autor:
Rink-Jan Lohman, Johan K. Hamidon, Robert C. Reid, Jessica A. Rowley, Mei-Kwan Yau, Maria A. Halili, Daniel S. Nielsen, Junxian Lim, Kai-Chen Wu, Zhixuan Loh, Anh Do, Jacky Y. Suen, Abishek Iyer, David P. Fairlie
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Complement C3a is an important protein in innate and adaptive immunity, but its roles in vivo are unclear. Here the authors develop novel chemical agonists and antagonists for the C3a receptor, and show that they modulate mast cell degranulation and
Externí odkaz:
https://doaj.org/article/9b55fdd2b33140c08bc5b8dacdba336c
Autor:
Asheley P. Chapman, Cody J. Higginson, David M. Francis, Alex Schudel, Alexa Regina Chua Avecilla, M. G. Finn, Susan N. Thomas, Mei-Kwan Yau, Nathan A. Rohner, Margaret P. Manspeaker
Publikováno v:
Nature nanotechnology
Therapeutic delivery selectively to lymph nodes has the potential to address a variety of unmet clinical needs. However, owing to the unique structure of the lymphatics and the size-restrictive nature of the lymph node reticular network, delivering c
Autor:
Robert Reid, Thomas Durek, Rink-Jan Lohman, Eunice K. Y. Poon, Abishek Iyer, David P. Fairlie, Jessica Rowley, Johan K. Hamidon, Maria A. Halili, Kai-Chen Wu, Junxian Lim, Mei-Kwan Yau
Publikováno v:
Journal of Medicinal Chemistry. 63:529-541
Structure-activity relationships for a series of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported antagonist SB290157. A new co
Publikováno v:
Angew Chem Int Ed Engl
Virus-like particles (VLPs) derived from Leviviridae virions contain substantial amounts of cellular and plasmid-derived RNA. This encapsidated polynucleotide serves as a reservoir for the efficient binding of the intercalating dye thiazole orange (T
Autor:
Lucrezia De Pascalis, Zhuoting Tan, Mei-Kwan Yau, M. G. Finn, Kendall N. Houk, Srinivas Tekkam, Dennis Svatunek
Publikováno v:
Organic letters, vol 23, iss 9
Org Lett
Org Lett
Oxanorbornadienes (ONDs) undergo facile Michael addition with thiols and then fragment by a retro-Diels-Alder (rDA) reaction, a unique two-step sequence among electrophilic cleavable linkages. The rDA reaction rate was explored as a function of the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00e28acc82d144485d58bb8a68362c4
https://escholarship.org/uc/item/7464k5bs
https://escholarship.org/uc/item/7464k5bs
Autor:
Alpha S. Yap, Benjamin M. Hogan, Stuart M. Pitson, Briony L. Gliddon, Guillermo A. Gomez, Anne K. Lagendijk, Mei-Kwan Yau, Robert G. Parton, Suzie Verma, Thomas E. Hall, Kinga Duszyc, David P. Fairlie
Epithelia must eliminate apoptotic cells to preserve tissue barriers and prevent inflammation [1]. Several different mechanisms exist for apoptotic clearance, including efferocytosis [2, 3] and apical extrusion [4, 5]. We found that extrusion was the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a22f803025034fc2222cbfb8226ef52e
https://doi.org/10.1101/2020.08.06.240671
https://doi.org/10.1101/2020.08.06.240671
Autor:
David P. Fairlie, Briony L. Gliddon, Suzie Verma, Bageshri Naimish Nanavati, Benjamin M. Hogan, Alpha S. Yap, Thomas E. Hall, Guillermo A. Gomez, Mei-Kwan Yau, Stuart M. Pitson, Anne K. Lagendijk, Robert G. Parton, Kinga Duszyc
Publikováno v:
Current biology : CB. 31(6)
Epithelia must eliminate apoptotic cells to preserve tissue barriers and prevent inflammation.1 Several different mechanisms exist for apoptotic clearance, including efferocytosis2,3 and apical extrusion.4,5 We found that extrusion was the first-line
Autor:
Weijun Xu, David P. Fairlie, Kai-Chen Wu, Jacky Y. Suen, Yuhong Jiang, Mei-Kwan Yau, Junxian Lim
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 364:246-257
Protease-activated receptor 2 (PAR2) is a cell surface protein linked to G-protein dependent and independent intracellular signaling pathways that produce a wide range of physiological responses, including those related to metabolism, inflammation, p
Autor:
Jessica Rowley, Jacky Y. Suen, Daniel S. Nielsen, Rink-Jan Lohman, Abishek Iyer, Mei-Kwan Yau, Robert Reid, Johan K. Hamidon, Zhixuan Loh, Anh Do, Kai-Chen Wu, Junxian Lim, Maria A. Halili, David P. Fairlie
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Complement C3a is an important protein in innate and adaptive immunity, but its specific roles in vivo remain uncertain because C3a degrades rapidly to form the C3a-desArg protein, which does not bind to the C3a receptor and is indistinguishable from
Autor:
David P. Fairlie, Junxian Lim, Weijun Xu, Adam J. Cotterell, Yaowu He, John D. Hooper, Mei-Kwan Yau, Mark N. Adams, Jacky Y. Suen, Praveen K. Madala
Publikováno v:
Pharmacological Research. 117:328-342
Proteinase-activated receptor 2 (PAR(2)) is a G protein -coupled receptor involved in metabolism, inflammation, and cancers. It is activated by proteolysis, which exposes a nascent N -terminal sequence that becomes a tethered agonist. Short synthetic