Výsledky vyhledávání - "Mei-Feng Shen"

Essential roles for Pot1b in HSC self-renewal and survival

Autor: Sandy Chang, Yang Wang, Mei-Feng Shen

Publikováno v: Blood. 118:6068-6077

Maintenance of mammalian telomeres requires both the enzyme telomerase and shelterin, which protect telomeres from inappropriately activating DNA damage response checkpoints. Dyskeratosis congenita is an inherited BM failure syndrome disorder because

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79271d769fdf03587d815e9ee646242
https://doi.org/10.1182/blood-2011-06-361527

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Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence

Autor: Wilfredo Cosme-Blanco, Guillermina Lozano, Alexander J. Lazar, Sen Pathak, Sandy Chang, Asha S. Multani, Mei Feng Shen

Publikováno v: EMBO reports. 8:497-503

Dysfunctional telomeres induce p53-dependent cellular senescence and apoptosis, but it is not known which function is more important for tumour suppression in vivo. We used the p53 R172P knock-in mouse, which is unable to induce apoptosis but retains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97785ba2aa223ca8d26e7d41cd7e1e73
https://doi.org/10.1038/sj.embor.7400937

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Pot1b Deletion and Telomerase Haploinsufficiency in Mice Initiate an ATR-Dependent DNA Damage Response and Elicit Phenotypes Resembling Dyskeratosis Congenita▿ †

Autor: Hua He, Mei-Feng Shen, Sandy Chang, Xiaolan Guo, Dennis A. Garcia, Yang Wang, Mingjian James You, Jin Ma, Sonal Ramchandani, Asha S. Multani, Yibin Deng

Telomeres are protein-DNA complexes that cap the ends of most eukaryotic chromosomes and maintain genomic stability by providing both end protection and a mechanism for maintenance of chromosomal ends. Mammalian telomeres consist of TTAGGG repetitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c73d0d39789102fe5b7b719f97d4ab
https://europepmc.org/articles/PMC2612488/

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Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling

Autor: Juan Carlos de la Torre, Keun Il Kim, Oxana A. Malakhova, Jiann-Kae Luo, Mei-Feng Shen, Weiguo Zou, Ming Yan, Dong-Er Zhang

Publikováno v: Molecular and cellular biology. 26(2)

The expression of ubiquitin-like modifier ISG15 and its conjugation to target proteins are highly induced by interferon (IFN) stimulation and during viral and bacterial infections. However, the biological significance of this modification has not bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5a37db669598aa62d7344dde1ddefd
https://pubmed.ncbi.nlm.nih.gov/16382139

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Ubp43 gene expression is required for normal Isg15 expression and fetal development

Autor: Mei-Feng Shen, Thomas R. Hansen, Lea A. Rempel, Kenneth J. Ritchie, Luiz E. Henkes, Dong-Er Zhang, Ming Yan, Kathleen J. Austin

Publikováno v: Reproductive Biology and Endocrinology
Reproductive Biology and Endocrinology, Vol 5, Iss 1, p 13 (2007)

BackgroundIsg15 covalently modifies murine endometrial proteins in response to early pregnancy. Isg15 can also be severed from targeted proteins by a specific protease called Ubp43 (Usp18). Mice lacking Ubp43 (null) form increased conjugated Isg15 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab59bf5486e460d83a48564a4a0df7af
http://europepmc.org/articles/PMC1852108

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