Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Mei-Fei Yueh"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 1, Pp 63-76.e5 (2016)
Background & Aims: The UDP-glucuronosyltransferases (UGTs) are a part of the cell machinery that protects the tissues from a toxicant insult by environmental and host cell metabolites. We investigated the mechanism behind tumor growth and UGT repress
Externí odkaz:
https://doaj.org/article/364ecff754ee45a99c2748eb91d23920
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37705 (2012)
Triclocarban (3,4,4'-trichlorocarbanilide, TCC) is used as a broad-based antimicrobial agent that is commonly added to personal hygiene products. Because of its extensive use in the health care industry and resistance to degradation in sewage treatme
Externí odkaz:
https://doaj.org/article/700de40030fa43509ab6d5c66e2c54c9
Autor:
Chen Chen, Feng He, Mei-Fei Yueh, Anupriya Tripathi, Catherine Vu, Shujuan Chen, Michael Karin, Robert H. Tukey, Rob Knight
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 49
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 49
Triclosan (TCS), employed as an antiseptic and disinfectant, comes into direct contact with humans through a plethora of consumer products and its rising environmental release. We have demonstrated that TCS promotes liver tumorigenesis in mice, yet t
Autor:
Miles Paszek, Mei-Fei Yueh, Wenqi Lu, Eva Rettenmeier, Jocelyn Trottier, Olivier Barbier, Shujuan Chen, Robert H. Tukey
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals, vol 45, iss 7
The gastrointestinal tract is enriched with xenobiotic processing proteins that play important roles in xenobiotic bioactivation, metabolism, and detoxification. The application of genetically modified mouse models has been instrumental in characteri
Autor:
Helena S. Domingues, Adelaide Fernandes, João B. Relvas, Mei-Fei Yueh, Robert H. Tukey, Andreia Barateiro, Olivier Barbier, Shujuan Chen, Dora Brites, Nghia Nguyen
Publikováno v:
Molecular Pharmacology. 89:84-93
Bilirubin-induced neurologic dysfunction (BIND) and kernicterus has been used to describe moderate to severe neurologic dysfunction observed in children exposed to excessive levels of total serum bilirubin (TSB) during the neonatal period. Here we us
Autor:
Bruce D. Hammock, Koji Taniguchi, Robert H. Tukey, Ronald M. Evans, Shujuan Chen, Michael Karin, Mei-Fei Yueh
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 48
Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; TCS] is a synthetic, broad-spectrum antibacterial chemical used in a wide range of consumer products including soaps, cosmetics, therapeutics, and plastics. The general population is exposed to TCS b
Autor:
Mei-Fei Yueh, Feng He, Chen Chen, Vu, Catherine, Tripathi, Anupriya, Knight, Rob, Karin, Michael, Shujuan Chen, Tukey, Robert H.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 12/8/2020, Vol. 117 Issue 49, p31259-31266, 8p
Autor:
Ronald M. Evans, Eva Rettenmeier, Miao Liu, Wenqi Lu, Miles Paszek, Ruth T. Yu, Shujuan Chen, Robert H. Tukey, Mei-Fei Yueh, Michael Karin, Kepeng Wang, Johan Auwerx
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Reference EPFL-ARTICLE-229716doi:10.1073/pnas.1705671114View record in Web of Science Record created on 2017-07-10, modified on 2017-07-10
Autor:
Johan Auwerx, Mei-Fei Yueh, Ruth T. Yu, Shujuan Chen, Ronald M. Evans, Michael Karin, Wenqi Lu, Eva Rettenmeier, Robert H. Tukey, Miles Paszek, Miao Liu, Kepeng Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 8
Severe neonatal hyperbilirubinemia (SNH) and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inability to metabolize bilirubin. Although there is a good
Publikováno v:
Molecular pharmacology, vol 91, iss 5
Hyperbilirubinemia, caused by the accumulation of unconjugated bilirubin, is one of the most common clinical diagnoses in both premature and term newborns. Owing to the fact that bilirubin is metabolized solely through glucuronidation by UDP-glucuron