Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Mei-Chun Cai"'
Autor:
Chenqiang Jia, Zhuqing Zhang, Jun Tang, Mei-Chun Cai, Jingyu Zang, Kaixuan Shi, Yunheng Sun, Jie Wu, Hailei Shi, Weiping Shi, Pengfei Ma, Xiaojing Zhao, Zhuang Yu, Yujie Fu, Guanglei Zhuang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
GSDME is a newly recognized executor of cellular pyroptosis, and has been recently implicated in tumor growth and immunity. However, knowledge about the molecular regulators underlying GSDME abundance remains limited. Here, we performed integrative b
Externí odkaz:
https://doaj.org/article/8a9728e0f19446ac8ee076f4facdeab5
Autor:
Pengfei Ma, Yujie Fu, Mei-Chun Cai, Ying Yan, Ying Jing, Shengzhe Zhang, Minjiang Chen, Jie Wu, Ying Shen, Liang Zhu, Hong-Zhuan Chen, Wei-Qiang Gao, Mengzhao Wang, Zhenyu Gu, Trever G. Bivona, Xiaojing Zhao, Guanglei Zhuang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Across cancer types tumor heterogeneity has been observed, but how this relates to tumor evolution is unclear. Here, the authors sequence multiple synchronous lung cancers, highlighting the evolutionary pressures that simultaneously shape the expansi
Externí odkaz:
https://doaj.org/article/1dc6dd11f0204afa83eef84ead94c50d
Autor:
Kaixuan Shi, Xia Yin, Mei-Chun Cai, Ying Yan, Chenqiang Jia, Pengfei Ma, Shengzhe Zhang, Zhenfeng Zhang, Zhenyu Gu, Meiying Zhang, Wen Di, Guanglei Zhuang
Publikováno v:
eLife, Vol 8 (2019)
PAX8 is a prototype lineage-survival oncogene in epithelial ovarian cancer. However, neither its underlying pro-tumorigenic mechanisms nor potential therapeutic implications have been adequately elucidated. Here, we identified an ovarian lineage-spec
Externí odkaz:
https://doaj.org/article/23227e3ca00146f3ae5aa1d88a5a76e5
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e80747 (2013)
Pattern genes are a group of genes that have a modularized expression behavior under serial physiological conditions. The identification of pattern genes will provide a path toward a global and dynamic understanding of gene functions and their roles
Externí odkaz:
https://doaj.org/article/1652576ede68496fab7c6d056c4abfd1
Autor:
Xiaoran Long, Huaiwu Lu, Mei-Chun Cai, Jingyu Zang, Zhuqing Zhang, Jie Wu, Xiaoshi Liu, Lin Cheng, Jiejun Cheng, Lydia W. T. Cheung, Zhen Shen, Ying Zhou, Wen Di, Guanglei Zhuang, Xia Yin
Publikováno v:
British Journal of Cancer. 128:2054-2062
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bffbc4ba242bf114fa274b0fe1975f1b
https://doi.org/10.1038/s41416-023-02239-5
https://doi.org/10.1038/s41416-023-02239-5
Autor:
Guanglei Zhuang, Wen Di, Wei-Qiang Gao, Kaixuan Shi, Shengzhe Zhang, Meiying Zhang, Jin Liu, Mei-Chun Cai, Ying Jing, Pengfei Ma, Xia Yin, Xiaojie Wang, Huixin Peng, Zhenfeng Zhang
Supplementary Figure 1. High-throughput small-molecule screen in ovarian cancer cells. Supplementary Figure 2. Inhibition of ovarian cancer cell viability by JQ1 and THZ1. Supplementary Figure 3. Cell cycle and apoptosis analysis upon THZ1 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5705ede5f2b4d39205089886431f0b0e
https://doi.org/10.1158/1535-7163.22507569
https://doi.org/10.1158/1535-7163.22507569
Autor:
Guanglei Zhuang, Wen Di, Wei-Qiang Gao, Kaixuan Shi, Shengzhe Zhang, Meiying Zhang, Jin Liu, Mei-Chun Cai, Ying Jing, Pengfei Ma, Xia Yin, Xiaojie Wang, Huixin Peng, Zhenfeng Zhang
Ovarian cancer remains a significant cause of gynecologic cancer mortality, and novel therapeutic strategies are urgently needed in clinic as new treatment options. We previously showed that BET bromodomain inhibitors displayed promising efficacy for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c84879a3f27419e41d32161df78e0793
https://doi.org/10.1158/1535-7163.c.6538725.v1
https://doi.org/10.1158/1535-7163.c.6538725.v1
Autor:
Guanglei Zhuang, Pengfei Ma, Zhuang Yu, Xiaojing Zhao, Jing Wang, Wenfeng Li, Yujie Fu, Mei-Chun Cai, Minjiang Chen, Jie Wu, Shengzhe Zhang, Haijiao Lu
Purpose:The induced death signals following oncogene inhibition underlie clinical efficacy of molecular targeted therapies against human cancer, and defects of intact cell apoptosis machinery often lead to therapeutic failure. Despite potential impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2100a2461c538a4cce64bc7aeee8c86c
https://doi.org/10.1158/1078-0432.c.6527331.v1
https://doi.org/10.1158/1078-0432.c.6527331.v1
Autor:
Guanglei Zhuang, Pengfei Ma, Zhuang Yu, Xiaojing Zhao, Jing Wang, Wenfeng Li, Yujie Fu, Mei-Chun Cai, Minjiang Chen, Jie Wu, Shengzhe Zhang, Haijiao Lu
A. TCGA pan-cancer genomic analysis of all the gasdermin family members. B. DFNA5 gene expression in TCGA lung adenocarcinomas classified by indicated genetic alterations. C. Western blot analysis of indicated proteins in nucleus, cytosol, mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be83a5aa6b36105d6305e69c850c1652
https://doi.org/10.1158/1078-0432.22469763.v1
https://doi.org/10.1158/1078-0432.22469763.v1
Autor:
Guanglei Zhuang, Wen Di, Meiying Zhang, Cong Xu, Yi Zhang, Pengfei Ma, Mei-Chun Cai, Ying Jing, Xia Yin
Synchronous bilateral ovarian cancer (SBOC) represents a relatively frequent occurrence and clinically relevant diagnostic dilemma. Delineation of its clonal architecture, genetic heterogeneity, and evolutionary trajectories may have important implic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd473e5dab97db4cfccdc1b2cecc25d
https://doi.org/10.1158/0008-5472.c.6509388.v1
https://doi.org/10.1158/0008-5472.c.6509388.v1