Zobrazeno 1 - 10
of 860
pro vyhledávání: '"Mei-Chuan Ko"'
Autor:
Norikazu Kiguchi, Yohji Fukazawa, Ayano Saika, Daisuke Uta, Fumihiro Saika, Tomoe Y. Nakamura, Mei‐Chuan Ko, Shiroh Kishioka
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 3, Pp n/a-n/a (2021)
Abstract Several lines of evidence have clarified that the key transmission pathways of itching sensation travel from the periphery to the central nervous system (CNS). Despite the functional significance of gastrin‐releasing peptide (GRP) and its
Externí odkaz:
https://doaj.org/article/77ff9906377a44668720debb1438e76b
Publikováno v:
Acta Dermato-Venereologica, Vol 99, Iss 6, Pp 587-893 (2019)
Neuromedin B is expressed in nociceptive and itch-sensitive dorsal root ganglia neurons, but its peripheral pruritogenic potential is not well described. The potential of neuromedin B as a pruritogen and pro-inflammatory peptide in the skin was teste
Externí odkaz:
https://doaj.org/article/71c6f787d86245f580a06a27aabd664a
Autor:
Santosh K. Mishra, Joshua J. Wheeler, Saumitra Pitake, Huiping Ding, Changyu Jiang, Tomoki Fukuyama, Judy S. Paps, Patrick Ralph, Jacob Coyne, Michelle Parkington, Jennifer DeBrecht, Lauren C. Ehrhardt-Humbert, Glenn P. Cruse, Wolfgang Bäumer, Ru-Rong Ji, Mei-Chuan Ko, Thierry Olivry
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Chronic allergic itch is a common symptom affecting millions of people and animals, but its pathogenesis is not fully explained. Herein, we show that periostin, abundantly expressed in the skin of patients with atopic dermatitis (AD), induce
Externí odkaz:
https://doaj.org/article/d9a4e1d17b0e47259c72065d38768e71
Publikováno v:
Journal of Pharmacological Sciences, Vol 128, Iss 2, Pp 83-86 (2015)
The anti-inflammatory properties of TC-2559, an α4β2 nicotinic acetylcholine receptor (nAChR) agonist, on cultured murine macrophages was investigated. TC-2559 suppressed the upregulation of CC-chemokine ligand 3 (CCL3) and interleukin-1β (IL-1β)
Externí odkaz:
https://doaj.org/article/5307e988d08644e7b50c0d9e392e504d
Autor:
Devki D Sukhtankar, Mei-Chuan Ko
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67422 (2013)
Pruritus (itch) is a severe side effect associated with the use of drugs as well as hepatic and hematological disorders. Previous studies in rodents suggest that bombesin receptor subtypes i.e. receptors for gastrin-releasing peptide (GRPr) and neuro
Externí odkaz:
https://doaj.org/article/624ae20978194513a4fd4795c713a7bb
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral.
Publikováno v:
The Journal of Pain. 24:36-37
Publikováno v:
Neuropharmacology. 223:109328
Opioids provide pain relief but are associated with several adverse effects. Researchers are exploring cannabis-based medicine as an alternative. However, little is known about the tendency for physical dependence on cannabinoids in comparison with t
Autor:
Ru-Rong Ji, Christopher R. Donnelly, Yu Lei, Huiping Ding, Michael S. Lee, Mei-Chuan Ko, Zilong Wang, William Maixner, Changyu Jiang, Kaiyuan Wang, Junli Zhao, Xin Luo, Amanda S. Andriessen
Publikováno v:
Nature
The innate immune regulator STING is a critical sensor of self- and pathogen-derived DNA. DNA sensing by STING leads to the induction of type-I interferons (IFN-I) and other cytokines, which promote immune-cell-mediated eradication of pathogens and n