Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Mei-Chu Lo"'
Autor:
Christopher Fotsch, Debaleena Basu, Ryan Case, Qing Chen, Pratibha C. Koneru, Mei-Chu Lo, Rachel Ngo, Pooja Sharma, Amit Vaish, Xiang Yi, Stephan G. Zech, Peter Hodder
Publikováno v:
SLAS Discovery, Vol 29, Iss 4, Pp 100159- (2024)
To confirm target engagement of hits from our high-throughput screening efforts, we ran biophysical assays on several hundreds of hits from 15 different high-throughput screening campaigns. Analyzing the biophysical assay results from these screening
Externí odkaz:
https://doaj.org/article/2deb87592cfb4d24ab3ef0bdbdb9d00b
Autor:
Mei-Chu Lo, 羅美珠
94
The purpose of the study was to understand the attitude of the faculty and the information system professionals of high schools and vocational high schools in Taipei, and their thinking about the information security management and the degree
The purpose of the study was to understand the attitude of the faculty and the information system professionals of high schools and vocational high schools in Taipei, and their thinking about the information security management and the degree
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/33v45m
Autor:
Kang Dai, Dineli Wickramasinghe, Alexander Kamb, Julio Medina, Lawrence R. McGee, Christophe Quéva, Timothy Carlson, Lily Liu, Ada Chen, Rachel Ngo, Sharon Zhao, Mei-Chu Lo, Jessica Orf, Grace Alba, Xianghong Wang, Justin Huard, Margaret Weidner, Lingming Liang, John Eksterowicz, David Hollenback, Suzanne Coberly, Mark Ragains, Ji Ma, Zhihong Li, Cong Li, Kathleen Keegan
PDF file - 132KB, Figure S1. Plasma concentration-time profiles of AMG 925 in rat, dog, and cynomolgus monkey following oral administration. Figure S2. Inhibition of STAT5 and Rb phosphorylation by AMG 925 in MOLM13-Luc tumor cells in bone marrow. Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216ae1da07e58a29878dbe9dcd4275af
https://doi.org/10.1158/1535-7163.22499853
https://doi.org/10.1158/1535-7163.22499853
Autor:
Lei Liu, Jason Long, Ingrid C. Rulifson, Brad Herberich, Miki Hardy, Oliver Homann, Monica Florio, Mei-Chu Lo, Jerry Ryan Holder, Shivani Singh, Hui Dou, Michael Ollmann, Elissa Swearingen, Danielle Pruitt, Kelvin K. C. Sham, Bin Wu, Justin K. Murray, Artem Shkumatov
Publikováno v:
Nucleic Acid Therapeutics. 31:324-340
Human genome wide association studies confirm the association of the rs738409 single nucleotide polymorphism (SNP) in the gene encoding protein patatin like phospholipase domain containing 3 (PNPLA...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2000bde8307608b78ff279a1e4c61b
https://doi.org/10.1089/nat.2021.0026
https://doi.org/10.1089/nat.2021.0026
Autor:
Gwenaella Rescourio, Ana Z. Gonzalez, Salman Jabri, Brian Belmontes, Gordon Moody, Doug Whittington, Xin Huang, Sean Caenepeel, Mario Cardozo, Alan C. Cheng, David Chow, Hannah Dou, Adrie Jones, Ron C. Kelly, Yihong Li, Mike Lizarzaburu, Mei-Chu Lo, Rommel Mallari, Cesar Meleza, Yosup Rew, Scott Simonovich, Daqing Sun, Simon Turcotte, Xuelei Yan, Simon G. Wong, Evelyn Yanez, Manuel Zancanella, Jonathan Houze, Julio C. Medina, Paul E. Hughes, Sean P. Brown
Publikováno v:
Journal of Medicinal Chemistry. 62:10258-10271
Overexpression of the antiapoptotic protein Mcl-1 provides a survival advantage to some cancer cells, making inhibition of this protein an attractive therapeutic target for the treatment of certain types of tumors. Herein, we report our efforts towar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e56bfd1df312774368ff5b90efcd7cc
https://doi.org/10.1021/acs.jmedchem.9b01310
https://doi.org/10.1021/acs.jmedchem.9b01310
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(2)
Since the revolutionary discovery of RNA interference (RNAi) more than 20 years ago, synthetic small interfering RNAs (siRNAs) have held great promise as therapeutic agents for treating human diseases by the specific knockdown of disease-causing gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4b5df416fe6b8a58b37efc4850613f
https://pubmed.ncbi.nlm.nih.gov/33016168
https://pubmed.ncbi.nlm.nih.gov/33016168
Supplemental material, Supplemental_Material_FISH_Dou_et_al for An Automated High-Throughput Fluorescence In Situ Hybridization (FISH) Assay Platform for Use in the Identification and Optimization of siRNA-Based Therapeutics by Hui H. Dou, Rommel Mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090d776c0c91cc7f0f381e150524036d
Autor:
Christine Sastri, Noelle Javier, Ryan Wurz, J. Russell Lipford, Hannah Dou, Mei-Chu Lo, Victor J. Cee, John McCarter, Ken Dellamaggiore, Dane Mohl
Publikováno v:
Journal of Medicinal Chemistry. 61:453-461
Proteolysis targeting chimeras (PROTACs) are bispecific molecules containing a target protein binder and an ubiquitin ligase binder connected by a linker. By recruiting an ubiquitin ligase to a target protein, PROTACs promote ubiquitination and prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecc44534d76887770e2aaa9542e5fc1
https://doi.org/10.1021/acs.jmedchem.6b01781
https://doi.org/10.1021/acs.jmedchem.6b01781
Autor:
Yue Hao, Aman Singh, Paolo Manzanillo, Mei-Chu Lo, Xin Huang, Amandine Créquer-Grandhomme, Hao Chen, Noelle Javier
Publikováno v:
The Journal of Biological Chemistry
β1,3-N-acetylglucosaminyltransferases (B3GNTs) are Golgi-resident glycosyltransferases involved in the biosynthesis of poly-N-acetyl-lactosamine chains. They catalyze the addition of the N-acetylglucosamine to the N-acetyl-lactosamine repeat as a ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fe86fe0077701edf64ca051bc912fb
https://doi.org/10.1074/jbc.ra120.015306
https://doi.org/10.1074/jbc.ra120.015306
Autor:
Wesley W. Barnhart, John B. Jordan, Kyung H. Gahm, Mei-Chu Lo, Heather Eastwood, John D. McCarter, Fang Xia, Jing Zhou
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 115:402-409
Analysis of nucleotide sugars, nucleoside di- and triphosphates and sugar-phosphates is an essential step in the process of understanding enzymatic pathways. A facile and rapid separation method was developed to analyze these compounds present in an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88cd954206e72bd0c7b93a3817e0bca
https://doi.org/10.1016/j.jpba.2015.08.001
https://doi.org/10.1016/j.jpba.2015.08.001