Zobrazeno 1 - 10 of 39 pro vyhledávání: '"Mei Zhen Luo"'
1
4-Nitrobenzyloxycarbonyl Derivatives of O6-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O6-Alkylguanine-DNA Alkyltransferase (AGT), Which Produces Resistance to Agents Targeting the O-6 Position of DNA Guanine
Autor: Mei-Zhen Luo, Rui Zhu, Krishnamurthy Shyam, Raymond P. Baumann, Philip G. Penketh, Mao-Chin Liu, Alan C. Sartorelli
Publikováno v: Journal of Medicinal Chemistry. 54:7720-7728
A series of 4-nitrobenzyloxycarbonyl prodrug derivatives of O(6)-benzylguanine (O(6)-BG), conceived as prodrugs of O(6)-BG, an inhibitor of the resistance protein O(6)-alkylguanine-DNA alkyltransferase (AGT), were synthesized and evaluated for their
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d795e4879742316731a8bbc1b0901940
https://doi.org/10.1021/jm201115f
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2
Calcium Distribution and Function during Anther Development ofTorenia fournieri(Linderniaceae)
Autor: Su-Hong Chen, Jingping Liao, Mei-Zhen Luo, Bruce K. Kirchoff
Publikováno v: Annales Botanici Fennici. 45:195-203
Potassium antimonite was used to locate calcium in the anthers of Torenia fournieri (Linderniaceae). Abundant calcium precipitates accumulate in the microsporocyte cytoplasm. After meiosis, calcium precipitates are abundant on the microspore wall, as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bea4abb11c469f1e9da1e4c8369dd4a2
https://doi.org/10.5735/085.045.0304
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5
AN IMPROVED SYNTHESIS OF 9-DEAZAGUANINE
Autor: Alan C. Sartorelli, Diane E. Mozdziesz, Mao-Chin Liu, Mei-Zhen Luo
Publikováno v: Synthetic Communications. 32:3797-3802
A new, improved synthesis of 9-deazaguanine is described. The method involves use of the benzyloxymethyl group to protect the N 3-position of 2-[(dimethylaminomethylene)- amino]-6-methyl-5-nitro-4(3H)-pyrimidinone, followed by treatment with DMF-dime
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cfad65ae20f7db6988f9b8b2596874
https://doi.org/10.1081/scc-120015398
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6
Synthesis and biological evaluation of l- and d-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides
Autor: Yung-Chi Cheng, Alan C. Sartorelli, Diane E. Mozdziesz, Tai-Shun Lin, Mao-Chin Liu, Ginger E. Dutschman, Elizabeth A. Gullen, Mei-Zhen Luo
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:2145-2148
Novel L- and D-configuration dioxolane 5-azacytosine and 6-azathymine nucleosides have been synthesized and evaluated for biological activity. (-)-(2S,4S)-1-[2-(Hydroxymethyl)-1,3-dioxolan-4-yl]-5-azacytosine (6) showed significant activity against H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85da6ac5fbf3da14e732fbb439f25ae8
https://doi.org/10.1016/s0960-894x(00)00418-2
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7
Synthesis of 2′-Methylene-Substituted 5-Azapyrimidine, 6-Azapyrimidine, and 3-Deazaguanine Nucleoside Analogues as Potential Antitumor/Antiviral Agents
Autor: Mao-Chin Liu, Mei-Zhen Luo, Diane E. Mozdziesz, Tai-Shun Lin, Ginger E., null Dutschman, Yung-Chi Cheng, Alan C. Sartorelli
Publikováno v: Nucleosides and Nucleotides. 18:55-72
2'-Deoxy-2'-methylene-6-azauridine (5) and 2'-deoxy-2'-methylene-6-azacytidine (8) have been synthesized via a multi-step procedure from 6-azauridine. 2'-Deoxy-2'-methylene-5-azacytidine (14a) and 2'-deoxy-2'-methylene-3-deazaguanosine (19a) and thei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960316c1c62c6ac7d142efcd6a39e60f
https://doi.org/10.1080/07328319908045594
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8
Synthesis of a Series of Purine 2′,3′-Dideoxy-L-Nucleoside Analogues as Potential Antiviral Agents
Autor: Ju-Liang Zhu, Tai-Shun Lin, Mao-Chin Liu, Ginger E. Dutschman, Yung-Chi Cheng, Yimei Zhu, Mei-Zhen Luo
Publikováno v: Nucleosides and Nucleotides. 14:1759-1783
Various 2′,3′-dideoxy-L-nucleoside analogues, 6-amino-9-(2,3-dideoxy-β-L-ribofuranosyl) purine (19), 2-chloro-6-amino-9-(2,3-dideoxy-β-L-ribofuranosyl)-purine (20), 2-chloro-6-amino-9-(2,3-dideoxy-4-thio-β-L-ribofuranosyl) purine (21), 2,6-dia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a22b28d4d6c15985348be4cb5d27f0f5
https://doi.org/10.1080/15257779508009755
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9
Studies of the Pharmacokinetics and Toxicology of 2',3'-Dideoxy-β-L-5-fluorocytidine (β-L-FddC) and 2',3'-Dideoxy-β-L-cytidine (β-L-ddC) In Vivo; and Synthesis and Antiviral Evaluations of 2',3'-Dideoxy-β-L-5-azacytidine
Autor: Mao-Chin Liu, Yong-Lian Zhu, Ginger E. Dutschman, S. Balakrishna Pai, Tai-Shun Lin, Mei-Zhen Luo, Yung-Chi Cheng, Mao-Mi Li, Xin Guo
Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 14:619-625
The pharmacokinetics and toxicology of 2′,3′-dideoxy-β-L-5-fluorocytidine (β-L-FddC) and 2′,3′-dideoxy-β-L-cytidine (β-L-ddC) in mice was investigated. In addition, 2′,3′-dideoxy-β-L-5-azacytidine (β-L-5-aza-ddC) and its α-L-anomer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b067bc1127fc844c189693eda9d8668
https://doi.org/10.1080/15257779508012438
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10
Synthesis of several pyrimidine l-nucleoside analogues as potential antiviral agents
Autor: Mei-Zhen Luo, Tai-Shun Lin, M.‐C. Liu
Publikováno v: Tetrahedron. 51:1055-1068
β- l -5-Iodo-2′-deoxyuridine (β- l -IUdR, 7) and 1-[(β- l - arabinofuranosyl )-E-5-(2- bromovinyl)]uracil (β- l -BV-ara-U, 10) have been synthesized via a multi-step synthesis from l -arabinose. 2′,3′-Dideoxy-β- l -5-azacytidine (18), 2′
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8c3ae6be2530b3b584d35acea9a5938
https://doi.org/10.1016/0040-4020(94)00997-9
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