Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mei Yuk Choi"'
Autor:
Timothy D. Martin, Danielle R. Cook, Mei Yuk Choi, Mamie Z. Li, Kevin M. Haigis, Stephen J. Elledge
Publikováno v:
Cell Reports, Vol 20, Iss 2, Pp 427-438 (2017)
Activating mutations in the KRAS oncogene are highly prevalent in tumors, especially those of the colon, lung, and pancreas. To better understand the genetic dependencies that K-Ras mutant cells rely upon for their growth, we employed whole-genome CR
Externí odkaz:
https://doaj.org/article/f368774e9f0d4ca591ee7e97f9432544
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2517-2526.e5 (2019)
Summary: The endoplasmic reticulum (ER) membrane protein complex (EMC) is a key contributor to biogenesis and membrane integration of transmembrane proteins, but our understanding of its mechanisms and the range of EMC-dependent proteins remains inco
Externí odkaz:
https://doaj.org/article/b5caf03056d64fdc8ec954551206fa9f
Autor:
Songhai Tian, Khaja Muneeruddin, Mei Yuk Choi, Liang Tao, Robiul H Bhuiyan, Yuhsuke Ohmi, Keiko Furukawa, Koichi Furukawa, Sebastian Boland, Scott A Shaffer, Rosalyn M Adam, Min Dong
Publikováno v:
PLoS Biology, Vol 16, Iss 11, p e2006951 (2018)
Glycosylation is a fundamental modification of proteins and membrane lipids. Toxins that utilize glycans as their receptors have served as powerful tools to identify key players in glycosylation processes. Here, we carried out Clustered Regularly Int
Externí odkaz:
https://doaj.org/article/0f48c87560b048dfb243742369a2031a
Autor:
Stephen J. Elledge, Rupesh S. Patel, Anthony C. Liang, Mamie Z. Li, Danielle R. Cook, Kevin M. Haigis, Timothy D. Martin, Ajinkya Patil, Mei Yuk Choi
Publikováno v:
Science. 373:1327-1335
Defining tumor cell immune evasion Mouse models used to study cancer often lack a full immune system, allowing implantation of human tumors into the mice. By contrast, naturally evolving tumors must contend with a fully functional immune system and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7393df1be74538b638d2b713ef231ea6
https://doi.org/10.1126/science.abg5784
https://doi.org/10.1126/science.abg5784
Autor:
Senchuan Song, Chung Man Chan, Hector K. Wang, Yanmin Huang, Lai Nar Tung, Ho Yu Lam, Hoi Ting Leung, Huacan Song, Zhiyong Chen, Mei Yuk Choi, Nikki P. Lee, Kin Tak Chan, Simon Law
Publikováno v:
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Purpose Tumor xenograft model is an indispensable animal cancer model. In esophageal squamous cell carcinoma (ESCC) research, orthotopic tumor xenograft model establishes tumor xenograft in the animal esophagus, which allows the study of tumorigenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8d02eb58b1aaab27c5878dce4a78fd
https://doi.org/10.4143/crt.2017.353
https://doi.org/10.4143/crt.2017.353
Autor:
Hong Chen, Hao Wu, Min Dong, Ji Zeng, Yang Liu, Liu Hao, Ralf Gerhard, Mei Yuk Choi, Songhai Tian
Publikováno v:
Cell Host Microbe
Summary The exotoxin TcsL is a major virulence factor in Paeniclostridium (Clostridium) sordellii and responsible for the high lethality rate associated with P. sordellii infection. Here, we present a genome-wide CRISPR-Cas9-mediated screen using a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacd190abad43026936fafb1ad124b8d
https://pubmed.ncbi.nlm.nih.gov/32302524
https://pubmed.ncbi.nlm.nih.gov/32302524
Autor:
Kristen E. Mengwasser, Richard O. Adeyemi, Mei Yuk Choi, Connor Clairmont, Yumei Leng, Stephen J. Elledge, Alan D. D'Andrea
BRCA1 or BRCA2 inactivation drives breast and ovarian cancer but also creates vulnerability to poly(ADP-ribose) polymerase (PARP) inhibitors. To search for additional targets whose inhibition is synthetically lethal in BRCA2-deficient backgrounds, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a77779d799d2b9f49f549a9641300dc
https://europepmc.org/articles/PMC6892393/
https://europepmc.org/articles/PMC6892393/
Autor:
Nikki P. Lee, Stella Chai, Stephanie Ma, Kwok Wah Chan, Mei Yuk Choi, Yan Ru Qin, Kin Tak Chan, Jin Na Chen, Sai Wah Tsao, Xin Yuan Guan, Tsun Ming Fung, KY Ng, Bin Li, Man Tong, Simon Law, Annie L. Cheung
Publikováno v:
The Journal of Pathology. 239:309-319
Oesophageal squamous cell carcinoma (ESCC) is the most common histological subtype of oesophageal cancer. The disease is particularly prevalent in southern China. The incidence of the disease is on the rise and its overall survival rate remains disma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50a748b56609e93da96f5498a86cf31b
https://doi.org/10.1002/path.4728
https://doi.org/10.1002/path.4728
Autor:
Hector K. Wang, Edgar S. L. Liu, Zhaoxiang Bian, Lai Nar Tung, Ho Yu Lam, Mung Yee Wong, Winnie Tan, Kin Tak Chan, Nikki P. Lee, Mei Yuk Choi, Sarwat Fatima, Pui Ying Tam
Publikováno v:
Journal of Applied Life Sciences International. 4:1-10
Aims: Monoclonal antibodies against tumor-related molecules are therapeutic agents for cancers. Promising results support the use of monoclonal antibodies in several cancers such as lung and breast cancer. However, using monoclonal antibodies as ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dd4c1997ca4c707bed400a0c3a40277
https://doi.org/10.9734/jalsi/2016/22188
https://doi.org/10.9734/jalsi/2016/22188
Autor:
Scott A. Shaffer, Liang Tao, Robiul H. Bhuiyan, Rosalyn M. Adam, Sebastian Boland, Koichi Furukawa, Keiko Furukawa, Mei Yuk Choi, Khaja Muneeruddin, Min Dong, Yuhsuke Ohmi, Songhai Tian
Publikováno v:
PLoS Biology, Vol 16, Iss 11, p e2006951 (2018)
PLoS Biology
PLoS Biology
Glycosylation is a fundamental modification of proteins and membrane lipids. Toxins that utilize glycans as their receptors have served as powerful tools to identify key players in glycosylation processes. Here, we carried out Clustered Regularly Int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1af87c480a0f369d69e5380018cb33c
http://europepmc.org/articles/PMC6258472?pdf=render
http://europepmc.org/articles/PMC6258472?pdf=render