Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Mei Y. Speer"'
Autor:
Subramanian Dharmarajan, Mei Y. Speer, Kate Pierce, Jake Lally, Elizabeth M. Leaf, Mu-En Lin, Marta Scatena, Cecilia M. Giachelli
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: Calcific aortic valve disease is common in the aging population and is characterized by the histological changes of the aortic valves including extracellular matrix remodeling, osteochondrogenic differentiation, and calcification. Combine
Externí odkaz:
https://doaj.org/article/3bbcae9c41154eefb33daa442b24a944
Autor:
Marta Scatena, Jake Lally, Cecilia M. Giachelli, Mu-En Lin, Elizabeth M. Leaf, Mei Y. Speer, Subramanian Dharmarajan, Kate Pierce
Publikováno v:
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: Calcific aortic valve disease is common in the aging population and is characterized by the histological changes of the aortic valves including extracellular matrix remodeling, osteochondrogenic differentiation, and calcification. Combine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a30baf0cae75bf3a5b203b6789683e
Autor:
Marta Scatena, Elizabeth M. Leaf, Cecilia M. Giachelli, Melissa F. Jackson, Mary C. Wallingford, Mei Y. Speer
Publikováno v:
Cardiovascular Pathology. 34:28-37
Objective Calcific aortic valve disease (CAVD) is a major cause of aortic stenosis (AS) and cardiac insufficiency. Patients with type II diabetes mellitus (T2DM) are at heightened risk for CAVD, and their valves have greater calcification than nondia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52f982e2a1bab7fcd9681e3d4a253d8
https://doi.org/10.1016/j.carpath.2018.02.002
https://doi.org/10.1016/j.carpath.2018.02.002
Autor:
Shunsuke Yamada, Mei Y. Speer, Cecilia M. Giachelli, Theodore M. Chen, Mu-En Lin, Mary C. Wallingford, Chenphop Sawangmake, Ngoc B. Nguyen, Jaimei Zhang
Publikováno v:
Cardiovascular Research. 112:606-616
Aims Vascular smooth muscle cells (SMCs) are major precursors contributing to osteochondrogenesis and calcification in atherosclerosis. Runt-related transcription factor-2 (Runx2) has been found essential for SMC differentiation to an osteochondrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe14b68fbc6c136a7ddf48ad9e66c49
https://doi.org/10.1093/cvr/cvw205
https://doi.org/10.1093/cvr/cvw205
Autor:
Cecilia M. Giachelli, Suhaib Borgeia, Mary C. Wallingford, Timothy C. Cox, Chenphop Sawangmake, Jia Jun Chia, Elizabeth M. Leaf, Kenneth I. Marro, Nicholas W. Chavkin, Mei Y. Speer
Publikováno v:
Brain Pathology. 27:64-76
Idiopathic basal ganglia calcification is a brain calcification disorder that has been genetically linked to autosomal dominant mutations in the sodium-dependent phosphate co-transporter, SLC20A2. The mechanisms whereby deficiency of Slc20a2 leads to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c763bcfd585e567531ff009e510332a
https://doi.org/10.1111/bpa.12362
https://doi.org/10.1111/bpa.12362
Publikováno v:
The American Journal of Pathology. 185:1958-1969
Arterial medial calcification (AMC) is a hallmark of aging, diabetes, and chronic kidney disease. Smooth muscle cell (SMC) transition to an osteogenic phenotype is a common feature of AMC, and is preceded by expression of runt-related transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b4a78119f23a965b8500dfdd802990
https://doi.org/10.1016/j.ajpath.2015.03.020
https://doi.org/10.1016/j.ajpath.2015.03.020
Autor:
Shunsuke Yamada, Jia Jun Chia, Cecilia M. Giachelli, Mei Y. Speer, Elizabeth M. Leaf, Timothy C. Cox
Publikováno v:
Kidney international. 94(4)
PiT-2, a type III sodium-dependent phosphate transporter, is a causative gene for the brain arteriolar calcification in people with familial basal ganglion calcification. Here we examined the effect of PiT-2 haploinsufficiency on vascular calcificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf8e838a15c4a4f84153cb6815ebf00
https://pubmed.ncbi.nlm.nih.gov/30243309
https://pubmed.ncbi.nlm.nih.gov/30243309
Autor:
Mei Y. Speer, Cecilia M. Giachelli
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 37(3)
Calcific aortic valve disease (CAVD), the progressive accumulation of fibrocalcific matrices and calcified, bony nodules in aortic valves that results in aortic stenosis, accounts for ≈50% of cardiac valve disease.1,2 In developed countries, CAVD i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b809ce6884d1ac2df59252aca9e62a5b
https://pubmed.ncbi.nlm.nih.gov/27932350
https://pubmed.ncbi.nlm.nih.gov/27932350
Autor:
Joseph M. Miano, Julie H. Campbell, Gary K. Owens, Mary C.M. Weiser-Evans, Michael Sturek, Elaine W. Raines, Giulio Gabbiani, Robert D. Bell, Alexander W. Clowes, Nancy J. Rusch, Cecilia M. Giachelli, Johan Thyberg, Anh T. Nguyen, Michael S. Parmacek, Chen Yan, Dwight A. Towler, Delphine Gomez, Mei Y. Speer
Publikováno v:
Circulation Research. 112:17-22
More than 50 years ago, smooth muscle cells (SMC) of the carotid artery were shown to undergo "de-differentiation" upon ligation injury. 1 Since this classic study, scores of research groups have used a variety of in vivo and in vitro model systems a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c040a1743d7094988ee98c72b745f900
https://doi.org/10.1161/circresaha.112.281048
https://doi.org/10.1161/circresaha.112.281048
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:321-326
Objectives— Vascular calcification is highly correlated with morbidity and mortality, and it is often associated with inflammation. Vitamin D may regulate vascular calcification and has been associated with cardiovascular survival benefits. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60682ab0c7a92d3217ff5c1b981a9eec
https://doi.org/10.1161/atvbaha.109.196576
https://doi.org/10.1161/atvbaha.109.196576