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Autor: Pranab K. Chanda, Franklin J. Moy, Mei Li Sung, Loran M. Killar, Robert Powers, Michael R. Pisano, Charlotte Urbano

Publikováno v: Journal of Biomolecular NMR. 10:9-19

Fibroblast collagenase (MMP-1), a 169-residue protein with amolecular mass of 18.7 kDa, is a matrix metalloproteinase which has beenassociated with pathologies such as arthritis and cancer. The assignments ofthe 1H, 15N, 13CO and13C resonances, deter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89eea26074a66760c0ab456490f6784b
https://doi.org/10.1023/a:1018362914316

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Analogs of the marine natural product scalaradial lacking the α,β-unsaturated aldehyde: effects on human synovial fluid phospholipase A2 and macrophage lipid mediator production

Autor: Mei-Li Sung, Yeung-Wai Lock, Anthony F. Kreft, Keith B. Glaser, Dennis Kubrak, Jean Bauer

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:1873-1878

The role of the α,β-unsaturated aldehyde in the inhibition of PLA2 by scalaradial was investigated by reduction to the triol and oxidation to the diacid. The results demonstrate that the reactivity of the α,β-unsaturated aldehyde of scalaradial i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e01e694f660b6c21ff54bf6fb9c93bf8
https://doi.org/10.1016/s0960-894x(01)80388-7

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Characterization of the mechanism underlying stonustoxin-mediated relaxant response in the rat aorta in vitro

Autor: Kerwin S.Y. Low, Julia Mei Li Sung, Hoon Eng Khoo

Publikováno v: Biochemical pharmacology. 63(6)

Stonustoxin (SNTX) is a lethal factor isolated from the venom of the stonefish Synanceja horrida. Although SNTX exhibits a multitude of biological activities, the primary cause of death upon administration of the toxin is attributed to marked hypoten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e9ebe201a13d07a6158dfd8d35b41c
https://pubmed.ncbi.nlm.nih.gov/11931843

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Structure-activity relationships leading to WAY-121,520, a tris aryl-type, indomethacin-based, phospholipase A2 (PLA2)/leukotriene biosynthesis inhibitor

Autor: A. Banker, John H. Musser, L. A. Marshall, Dennis Kubrak, Amedeo Arturo Failli, Mei-Li Sung, Robert J. Sturm, James Albert Nelson, Jean Bauer, Robert John Steffan, Anthony F. Kreft, G. Schiehser, D. A. Holloway, Keith B. Glaser, Uresh Shantilal Shah

Publikováno v: Agents and actions.

We were intrigued by reports of the inhibition of phospholipase A2 (PLA2) by indomethacin. In order to increase the potency of the indomethacin system as an inhibitor of PLA2, it was decided to make more lipophilic analogs. Indeed, covalent attachmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b545208e3c8d750547d7daecdc19dc2b
https://pubmed.ncbi.nlm.nih.gov/8273578

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