Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Mei Jung Lai"'
Autor:
Samir Mehndiratta, Mei-Chuan Chen, Yuh-Hsuan Chao, Cheng-Hsin Lee, Jing-Ping Liou, Mei-Jung Lai, Hsueh-Yun Lee
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 74-84 (2021)
A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8. The results indicated that subs
Externí odkaz:
https://doaj.org/article/c7b114e2cce340f3bb76c939739aacb5
Autor:
Min-Wu Chao, Li-Hsun Chang, Huang-Ju Tu, Chao-Di Chang, Mei-Jung Lai, Yi-Ying Chen, Jing-Ping Liou, Che-Ming Teng, Shiow-Lin Pan
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-14 (2019)
Abstract Background Oncogenic K-Ras signaling highly relies on the canonical Ras/MEK/ERK pathway to contribute to pancreatic cancer progression. However, numerous efforts of MEK inhibitors have failed to provide an optimal antitumor effect for pancre
Externí odkaz:
https://doaj.org/article/a43186bb4cd346d8948e060ed50b9538
Autor:
Tai-Ju Hsu, Kunal Nepali, Chi-Hao Tsai, Zuha Imtiyaz, Fan-Li Lin, George Hsiao, Mei-Jung Lai, Yu-Wen Cheng
Publikováno v:
Molecules, Vol 26, Iss 14, p 4359 (2021)
Age-related macular degeneration (AMD) occurs due to an abnormality of retinal pigment epithelium (RPE) cells that leads to gradual degeneration of the macula. Currently, AMD drug pipelines are endowed with limited options, and anti-VEGF agents stand
Externí odkaz:
https://doaj.org/article/9fabd4ff14134aeeb3099593b9b40ea7
Autor:
Mei-Jung Lai, Hsueh-Yun Lee, Hsun-Yueh Chuang, Li-Hsun Chang, An-Chi Tsai, Mei-Chuan Chen, Han-Li Huang, Yi-Wen Wu, Che-Ming Teng, Shiow-Lin Pan, Yi-Min Liu, Samir Mehndiratta, Jing-Ping Liou
Publikováno v:
Journal of Medicinal Chemistry. 66:6436-6436
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e846ef63bfd5bf5af06f3007774a8abb
https://doi.org/10.1021/acs.jmedchem.3c00574
https://doi.org/10.1021/acs.jmedchem.3c00574
Autor:
Mei Chuan Chen, Samir Mehndiratta, Hsueh Yun Lee, Jing Ping Liou, Yuh Hsuan Chao, Mei Jung Lai, Cheng Hsin Lee
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 74-84 (2021)
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 74-84 (2021)
A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8. The results indicated that subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e9a5413fabde1d3680449630eee5da
http://europepmc.org/articles/PMC7655065
http://europepmc.org/articles/PMC7655065
Autor:
Kunal Nepali, An-Chih Wu, Wei-Lun Lo, Bhawna Chopra, Mei-Jung Lai, Jian-Ying Chuang, Jing-Ping Liou
Publikováno v:
European Journal of Medicinal Chemistry. 248:115054
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ed60e428d2db99ea42d6e806bc26ed0
https://doi.org/10.1016/j.ejmech.2022.115054
https://doi.org/10.1016/j.ejmech.2022.115054
Autor:
Yu-Ling Chen1 chenyulin66@gmail.com, Mei-Jung Lai2 mjlai@fcu.edu.tw
Publikováno v:
International Journal of Organizational Innovation. Apr2019, Vol. 11 Issue 4, p250-261. 12p.
Autor:
George Hsiao, Chi Hao Tsai, Tai Ju Hsu, Zuha Imtiyaz, Kunal Nepali, Fan Li Lin, Yu Wen Cheng, Mei Jung Lai
Publikováno v:
Molecules, Vol 26, Iss 4359, p 4359 (2021)
Molecules
Volume 26
Issue 14
Molecules
Volume 26
Issue 14
Age-related macular degeneration (AMD) occurs due to an abnormality of retinal pigment epithelium (RPE) cells that leads to gradual degeneration of the macula. Currently, AMD drug pipelines are endowed with limited options, and anti-VEGF agents stand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b291160a8c8c52433f1fb7667fcf00f
https://www.mdpi.com/1420-3049/26/14/4359
https://www.mdpi.com/1420-3049/26/14/4359
Autor:
Chi Yen Chang, Kai Cheng Hsu, Tony Eight Lin, Mei Hsiang Lin, Kunal Nepali, Mei Jung Lai, Mei Chuan Chen, Jing Ping Liou, Hsueh Yun Lee, Ritu Ojha, Jang Yang Chang, Yi Min Liu
Publikováno v:
European Journal of Medicinal Chemistry. 162:612-630
We report structure-activity relationships of 1-arylsulfonyl indoline based benzamides. The benzamide (9) exhibits striking tubulin inhibition with an IC50 value of 1.1 μM, better than that of combretastain A-4 (3), and substantial antiproliferative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4a8daccd91c55a8cd3f634058cfae9
https://doi.org/10.1016/j.ejmech.2018.10.066
https://doi.org/10.1016/j.ejmech.2018.10.066
Autor:
Kunal Nepali, Mei Jung Lai, Kai Cheng Hsu, Tony Eight Lin, Jing Ping Liou, Wei Lun Lo, Tsung I. Hsu, Jian Ying Chuang, Chien Ming Hsieh
Publikováno v:
European journal of medicinal chemistry. 217
Hurdled and marred by the notorious nature of glioblastomas (GBM) in terms of resistance to therapy and limited drug delivery into the brain, the anti-GBM drug pipeline is required to be loaded with mechanistically diverse agents. The consideration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2b2d70b0c7793d1cf8f9cf61892485
https://pubmed.ncbi.nlm.nih.gov/33744690
https://pubmed.ncbi.nlm.nih.gov/33744690