Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Mei Hua Gao"'
Autor:
Mei Hua Gao, Dimosthenis Giamouridis, N. Chin Lai, Tracy Guo, Bing Xia, Young Chul Kim, Viet Anh Nguyen Huu, Dorota Skowronska-Krawczyk, Louise Lantier, Raag Bhargava, H. Kirk Hammond
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 220-233 (2020)
Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events. We tested urocortin
Externí odkaz:
https://doaj.org/article/828e78bc7b3643b49492393e8da28c44
Autor:
Dimosthenis Giamouridis, BS, MS, Mei Hua Gao, PhD, N. Chin Lai, PhD, Zhen Tan, PhD, Young Chul Kim, PhD, Tracy Guo, BS, Atsushi Miyanohara, PhD, W. Matthijs Blankesteijn, PhD, Erik Biessen, PhD, H. Kirk Hammond, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 249-264 (2018)
Summary: UCn2 and UCn3 peptides have recently been infused to treat patients with heart failure (HF) but are limited by their short half-lives. A 1-time intravenous injection of virus vectors encoding UCn2 or UCn3 provided sustained increases in plas
Externí odkaz:
https://doaj.org/article/7f669bc55c904d3d97cf15fd9a30d1e9
Autor:
Mei Hua Gao, PhD, N. Chin Lai, PhD, Dimosthenis Giamouridis, MSc, Young Chul Kim, PhD, Zhen Tan, PhD, Tracy Guo, BS, Wolfgang H. Dillmann, MD, Jorge Suarez, PhD, H. Kirk Hammond, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 617-629 (2016)
Transgenic mice with cardiac-directed C1C2, a fusion protein of the intracellular C1 and C2 segments of adenylyl cyclase type 6, had normal left ventricular (LV) function, but diminished cAMP generation. Cardiac myocytes from C1C2 mice showed increas
Externí odkaz:
https://doaj.org/article/c3d4b2955ed24706befb04be3dee1927
Autor:
Young Chul Kim, Agnieszka D Truax, Dimosthenis Giamouridis, N Chin Lai, Tracy Guo, H Kirk Hammond, Mei Hua Gao
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0224428 (2019)
IntroductionUrocortin 2 (Ucn2) is a 38-amino acid peptide of the corticotropin-releasing factor family. Intravenous (IV) delivery of an adeno-associated virus vector serotype 8 encoding Ucn2 (AAV8.Ucn2) increases insulin sensitivity and glucose dispo
Externí odkaz:
https://doaj.org/article/a76d1ce9339e432589e71472f8999c89
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181282 (2017)
Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways. We previously generated a catalytically inactive mutant of AC6 (AC6mut) t
Externí odkaz:
https://doaj.org/article/a04ae54f71fd4853b07adb6d4178d6d9
Autor:
Mei Hua Gao, Ngai Chin Lai, Tong Tang, Tracy Guo, Ruoying Tang, Byeong Jo Chun, Hong Wang, Nancy N Dalton, Jorge Suarez, Wolfgang H Dillmann, H Kirk Hammond
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72151 (2013)
So many clinical trials of positive inotropes have failed, that it is now axiomatic that agents that increase cAMP are deleterious to the failing heart. An alternative strategy is to alter myocardial Ca(2+) handling or myofilament response to Ca(2+)
Externí odkaz:
https://doaj.org/article/76ec15caafda425fa06285823978e134
Publikováno v:
Iranian Journal of Immunology, Vol 20, Iss 1, Pp 67-75 (2023)
Background: The extent to which maternal antibodies against the hepatitis B surface antigen (HBsAb) acquired transplacentally affect the immune responses to the hepatitis B vaccine (HBVac) in infants is still uncertain.Objective: To explore the impac
Externí odkaz:
https://doaj.org/article/d6ff38a38f6f4637a713514204c10c4c
Publikováno v:
Human Gene Therapy. 33:1091-1100
We used transverse aortic constriction (TAC) in mice to test the hypothesis thatiurocortin 2/i(iUcn2/i) gene transfer would increase left ventricular (LV) systolic and diastolic function in the pressure-stressed LV. Three groups were studied: (1) con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0499e632fa3dc48effbab55a8a54d4a
https://doi.org/10.1089/hum.2022.132
https://doi.org/10.1089/hum.2022.132
Autor:
Young Chul Kim, N. Chin Lai, Tracy Guo, Bing Xia, Zhenxing Fu, Mei Hua Gao, Dimosthenis Giamouridis, H. Kirk Hammond
Publikováno v:
Hum Gene Ther
Diabetes mellitus is associated with increased risk of heart failure. It has been previously demonstrated in mice that a single injection of adeno-associated virus 8 encoding urocortin 2 (AAV8.UCn2) increases glucose disposal in models of insulin res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8568e785265894a596516b58eba06af1
https://doi.org/10.1089/hum.2018.150
https://doi.org/10.1089/hum.2018.150
Autor:
Dimosthenis Giamouridis, Young Chul Kim, H. Kirk Hammond, Bing Xia, Mei Hua Gao, Zhen Tan, Tracy Guo, N. Chin Lai
Publikováno v:
Hum Gene Ther
A fusion protein (C1C2) constructed by fusing the intracellular C1 and C2 segments of adenylyl cyclase type 6 (AC6) retains beneficial effects of AC6 expression, without increasing cyclic adenosine monophosphate generation. The effects of cardiac-dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4512629e0381a2749066088f28b0dee
https://doi.org/10.1089/hum.2018.176
https://doi.org/10.1089/hum.2018.176