Evaluation of marketing authorization and clinical implementation of ulipristal acetate for uterine fibroids

Autor: Mei-An Middelkoop, Maria E de Lange, T Justin Clark, Ben Willem J Mol, Pierre M Bet, Judith A F Huirne, Wouter J K Hehenkamp

Publikováno v: Middelkoop, M-A, de Lange, M E, Clark, T J, Mol, B W J, Bet, P M, Huirne, J A F & Hehenkamp, W J K 2022, ' Evaluation of marketing authorization and clinical implementation of ulipristal acetate for uterine fibroids ', Human reproduction (Oxford, England), vol. 37, no. 5, pp. 884-894 . https://doi.org/10.1093/humrep/deac009

Ulipristal acetate (UPA) is a medical treatment for uterine fibroids and was authorized for surgical pre-treatment in 2012 after the conduct of the PEARL I and II randomized controlled trials and for intermittent treatment after the observational PEA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d305f460dbe110f370fa6ff6f7b66a7
https://doi.org/10.1093/humrep/deac009

Endometrial Angiogenesis of Abnormal Uterine Bleeding and Infertility in Patients with Uterine Fibroids—A Systematic Review

Autor: Emma E. Don, Mei-An Middelkoop, Wouter J. K. Hehenkamp, Velja Mijatovic, Arjan W. Griffioen, Judith A. F. Huirne

Publikováno v: Don, E E, Middelkoop, M-A, Hehenkamp, W J K, Mijatovic, V, Griffioen, A W & Huirne, J A F 2023, ' Endometrial Angiogenesis of Abnormal Uterine Bleeding and Infertility in Patients with Uterine Fibroids—A Systematic Review ', International Journal of Molecular Sciences, vol. 24, no. 8, 7011 . https://doi.org/10.3390/ijms24087011, https://doi.org/10.3390/ijms24087011

Uterine fibroids are the most common benign tumors in women, with abnormal uterine bleeding (AUB) as the main reported symptom. Additionally, an association between fibroids and infertility has been established, especially if the fibroid protrudes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9693bd4ab18c8afc2155637d67f2a179
https://doi.org/10.3390/ijms24087011

A multi-centre, randomized, non-inferiority trial to compare ulipristal with standard surgical treatment in women with symptomatic uterine fibroids

Autor: Marijke C. Jansen-van der Weide, Mei-An Middelkoop, Wouter J.K. Hehenkamp, Judith E. Bosmans, Judith A.F. Huirne

Publikováno v: Middelkoop, M A, Huirne, J A F, van der Weide, M C J, Bosmans, J E & Hehenkamp, W J K 2021, ' A multi-centre, randomized, non-inferiority trial to compare ulipristal with standard surgical treatment in women with symptomatic uterine fibroids : Protocol of the MYOMEX-2 trial ', European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 256, pp. 63-69 . https://doi.org/10.1016/j.ejogrb.2020.10.058
Middelkoop, M-A, Huirne, J A F, van der Weide, M C J, Bosmans, J E & Hehenkamp, W J K 2021, ' A multi-centre, randomized, non-inferiority trial to compare ulipristal with standard surgical treatment in women with symptomatic uterine fibroids : Protocol of the MYOMEX-2 trial ', European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 256, pp. 63-69 . https://doi.org/10.1016/j.ejogrb.2020.10.058
European Journal of Obstetrics and Gynecology and Reproductive Biology, 256, 63-69. Elsevier Ireland Ltd

© 2020 The Author(s)Objectives: Fibroids are the most common benign tumours found in the uterus and can cause various symptoms. In 20–50 % of the women, an intervention is required. When conservative options fail, invasive options such as hysterec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a3c5245b46ec8597c0caa35c008b2c
https://doi.org/10.1016/j.ejogrb.2020.10.058

Ulipristal acetate versus gonadotropin-releasing hormone agonists prior to laparoscopic myomectomy (MYOMEX trial): Long term results of a double-blind randomized controlled trial

Autor: Judith A.F. Huirne, Marchien W. van Baal, Wouter J.K. Hehenkamp, Peggy M.A.J. Geomini, Inge de Milliano, Judith E. Bosmans, Benedictus C. Schoot, Janet Kwee, Mei An Middelkoop

Publikováno v: European Journal of Obstetrics and Gynecology and Reproductive Biology, 252, 256-264. Elsevier Ireland Ltd
De Milliano, I, Middelkoop, M A, Huirne, J A F, Kwee, J, Geomini, P M A J, Schoot, B C, Van Baal, M, Bosmans, J E & Hehenkamp, W J K 2020, ' Ulipristal acetate versus gonadotropin-releasing hormone agonists prior to laparoscopic myomectomy (MYOMEX trial): Long term results of a double-blind randomized controlled trial ', European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 252, pp. 256-264 . https://doi.org/10.1016/j.ejogrb.2020.06.035
De Milliano, I, Middelkoop, M A, Huirne, J A F, Kwee, J, Geomini, P M A J, Schoot, B C, Van Baal, M, Bosmans, J E & Hehenkamp, W J K 2020, ' Ulipristal acetate versus gonadotropin-releasing hormone agonists prior to laparoscopic myomectomy (MYOMEX trial) : Long term results of a double-blind randomized controlled trial ', European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 252, pp. 256-264 . https://doi.org/10.1016/j.ejogrb.2020.06.035

Objective: The aim of this study was to compare the effect of ulipristal acetate (UPA) and gonadotropin-releasing hormone agonists (GnRHa) before laparoscopic myomectomy on long term secondary outcomes of the MYOMEX-trial, regarding quality of life,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697315a3658720abb985bed2aad4c6e8
https://research.vu.nl/en/publications/2c891527-7c1a-4766-866b-6d986411d0d3