Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mei‐Yi Yan"'
Autor:
Mei‐Yi Yan, Haifeng Li, Yun‐Mo Qu, Si‐Shang Li, Dandan Zheng, Xiao‐Peng Guo, Zhaojun Wu, Jie Lu, Yu Pang, Weimin Li, Jian Yang, Lingjun Zhan, Yi‐Cheng Sun
Publikováno v:
Advanced Science, Vol 11, Iss 39, Pp n/a-n/a (2024)
Abstract Tuberculosis (TB), the leading cause of death from bacterial infections worldwide, results from infection with Mycobacterium tuberculosis (Mtb). The antitubercular agents delamanid (DLM) and pretomanid (PMD) are nitroimidazole prodrugs that
Externí odkaz:
https://doaj.org/article/546649a5c07c4238ad50e9606a434aca
Autor:
Lan-Yue Zhang, Chun-Liang Wang, Mei-Yi Yan, Yi-Man Geng, Han Yin, Hong-Yan Jia, Chuan-Zhi Zhu, Zi-Hui Li, Gai-Xian Ren, Li-Ping Pan, Yi-Cheng Sun, Zong-De Zhang
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Toxin-antitoxin (TA) systems are ubiquitous genetic elements in prokaryotes, but their biological importance is poorly understood. Mycobacterium smegmatis contains eight putative TA systems. Previously, seven TAs have been studied, with five
Externí odkaz:
https://doaj.org/article/bdbee599117b45fbbf5ef7f1d6ceb2b1
Autor:
Xin-Yuan Ding, Si-Shang Li, Yi-Man Geng, Mei-Yi Yan, Guo-Bao Li, Guo-Liang Zhang, Yi-Cheng Sun
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2021)
Multidrug-resistant Mycobacterium tuberculosis (Mtb) infection seriously endangers global human health, creating an urgent need for new treatment strategies. Efficient genome editing tools can facilitate identification of key genes and pathways invol
Externí odkaz:
https://doaj.org/article/75994ec9eeba4a85a9eb8d6c2919e600
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT New tools for genetic manipulation of Mycobacterium tuberculosis are needed for the development of new drug regimens and vaccines aimed at curing tuberculosis infections. Clustered regularly interspaced short palindromic repeat (CRISPR)–CR
Externí odkaz:
https://doaj.org/article/d5efd17612704f668563a19bea374a8f
Autor:
Mei-Yi Yan, Dandan Zheng, Si-Shang Li, Xin-Yuan Ding, Chun-Liang Wang, Xiao-Peng Guo, Lingjun Zhan, Qi Jin, Jian Yang, Yi-Cheng Sun
Publikováno v:
Science Advances. 8
CRISPR screening, including CRISPR interference (CRISPRi) and CRISPR-knockout (CRISPR-KO) screening, has become a powerful technology in the genetic screening of eukaryotes. In contrast with eukaryotes, CRISPR-KO screening has not yet been applied to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63ffae696f4c012174f79186ebf8b882
https://doi.org/10.1126/sciadv.add5907
https://doi.org/10.1126/sciadv.add5907
Publikováno v:
mBio, Vol 11, Iss 1, p e02364-19 (2020)
mBio
mBio, Vol 11, Iss 1 (2020)
mBio
mBio, Vol 11, Iss 1 (2020)
The global health impact of M. tuberculosis necessitates the development of new genetic tools for its manipulation, to facilitate the identification and characterization of novel drug targets and vaccine candidates. Clustered regularly interspaced sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68f10ae0e46da7677c088c5b31f256f
https://doaj.org/article/59173386e1284a89a71b6357fe709683
https://doaj.org/article/59173386e1284a89a71b6357fe709683
Publikováno v:
Applied and Environmental Microbiology
Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas12a (Cpf1) has emerged as an effective genome editing tool in many organisms. Here, we developed and optimized a CRISPR-Cas12a-assisted recombineering system to facilitate genetic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274e6f3424f52f702d7d88f894f7a265
http://europepmc.org/articles/PMC5561284
http://europepmc.org/articles/PMC5561284
Publikováno v:
Scientific Reports
Research on mycobacterial genetics relies heavily on techniques for directed gene mutation, but genetic studies are often hampered by the difficulty of generating gene deletions in mycobacteria. We developed an efficient and improved deletion system,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3a27770d550c8c0a3fc0c1437c7b41
https://pubmed.ncbi.nlm.nih.gov/26972108
https://pubmed.ncbi.nlm.nih.gov/26972108
Autor:
Mei-Yi Yan1, Hai-Qin Yan2, Gai-Xian Ren1, Ju-Ping Zhao1, Xiao-Peng Guo1, Yi-Cheng Sun1 sunyc@ipbcams.ac.cn
Publikováno v:
Applied & Environmental Microbiology. Sep2017, Vol. 83 Issue 17, p1-13. 13p.
Publikováno v:
Terrestrial, Atmospheric and Oceanic Sciences, Vol 28, Iss 2, p 157 (2017)
Composite material has been widely applied in space vehicle structures due to its light weight and designed stiffness modulus. Some special mechanical properties that cannot be changed in general metal materials, such as low CTE (coefficient of therm
Externí odkaz:
https://doaj.org/article/741a4838c7d440d3869ca476a4ce683e