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Deregulation of JAK2 signaling underlies primary cutaneous CD8(+) aggressive epidermotropic cytotoxic T-cell lymphoma

Autor: Torres, A.N.B., Cats, D., Out-Luiting, J.J., Fanoni, D., Mei, H.L., Venegoni, L., Willemze, R., Vermeer, M.H., Berti, E., Tensen, C.P.

Publikováno v: Haematologica, 107(3), 702-714. FERRATA STORTI FOUNDATION

Primary cutaneous CD8(+) aggressive epidermotropic cytotoxic T-cell lymphoma (pcAECyTCL) is a rare variant of cutaneous T-cell lymphoma with an aggressive clinical course and a very poor prognosis. Until now, neither a systematic characterization of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::06bebfa8fa3b192b6780ee55918c4d42
http://hdl.handle.net/1887/3564007

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A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

Autor: Ouwens, K.G., Jansen, R., Nivard, M.G., Dongen, J. van, Frieser, M.J., Hottenga, J.J., Arindrarto, W., Claringbould, A., Iterson, M. van, Mei, H.L., Franke, L., Heijmans, B.T., Hoen, P.A.C. 't, Meurs, J. van, Brooks, A.I., Penninx, B.W.J.H., Boomsma, D.I., Isaacs, A., Pool, R., Greevenbroek, M.M.J. van, Stehouwer, C.D.A., Kallen, C.J.H. van der, Schalkwijk, C.G., Wijmenga, C., Zhernakova, S., Tigchelaar, E.F., Slagboom, P.E., Beekman, M., Deelen, J., Heemst, D. van, Veldink, J.H., Berg, L.H. van den, Duijn, C.M. van, Hofman, B.A., Uitterlinden, A.G., Jhamai, P.M., Verbiest, M., Suchiman, H.E.D., Verkerk, M., Breggen, R. van der, Rooij, J. van, Lakenberg, N., Galen, M. van, Bot, J., Zhernakova, D.V., van't Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Luijk, R., Bonder, M.J., Dijk, F. van, Kielbasa, S.M., Swertz, M.A., Zwet, E.W. van, Hoen, P.B. 't, BIOS Consortium

Publikováno v: Ouwens, K G, Jansen, R, Nivard, M G, van Dongen, J, Frieser, M J, Hottenga, J-J, Arindrarto, W, Claringbould, A, van Iterson, M, Mei, H, Franke, L, Heijmans, B T, A. C. ’t Hoen, P, van Meurs, J, Brooks, A I, Boomsma, D I, Penninx, B W J H & BIOS Consortium 2020, ' A characterization of cis-and trans-heritability of RNA-Seq-based gene expression ', European Journal of Human Genetics, vol. 28, no. 2, pp. 253-263 . https://doi.org/10.1038/s41431-019-0511-5
European Journal of Human Genetics, 28(2), 253-263. Nature Publishing Group
Ouwens, K G, Jansen, R, Nivard, M G, van Dongen, J, Hottenga, J-J, Penninx, B W J H, Boomsma, D I & BIOS Consortium 2020, ' A characterization of cis-and trans-heritability of RNA-Seq-based gene expression ', European Journal of Human Genetics, vol. 28, no. 2, pp. 253-263 . https://doi.org/10.1038/s41431-019-0511-5
European Journal of Human Genetics, 28, 253-263
Eur J Hum Genet
European Journal of Human Genetics, 28, 2, pp. 253-263
European Journal of Human Genetics, 28(2), 253-263. NATURE PUBLISHING GROUP

Insights into individual differences in gene expression and its heritability (h2) can help in understanding pathways from DNA to phenotype. We estimated the heritability of gene expression of 52,844 genes measured in whole blood in the largest twin R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b724edc5b8ecf280bc310da19b2529ee
https://research.vumc.nl/en/publications/029df33c-d648-47cb-b258-60c60eed93d1

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Genome-wide identification of directed gene networks using large-scale population genomics data

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications, 9
Nature Communications
Nature Communications, 9(1):3097. Nature Publishing Group
Suchiman, H E D, Hottenga, J J, Pool, R, Boomsma, D I & BIOS (Biobank-based Integrative Omics Study) Consortium 2018, ' Genome-wide identification of directed gene networks using large-scale population genomics data ', Nature Communications, vol. 9, 3097, pp. 1-10 . https://doi.org/10.1038/s41467-018-05452-6
BIOS (Biobank-based Integrative Omics Study) Consortium 2018, ' Genome-wide identification of directed gene networks using large-scale population genomics data ', Nature Communications, vol. 9, no. 1, 3097 . https://doi.org/10.1038/s41467-018-05452-6
Nature Communications, 9:3097. Nature Publishing Group
Nature Communications, 9:3097, 1-10. Nature Publishing Group

Identification of causal drivers behind regulatory gene networks is crucial in understanding gene function. Here, we develop a method for the large-scale inference of gene–gene interactions in observational population genomics data that are both di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060e82b855f6db931b76c0e10e79a748
https://doi.org/10.1038/s41467-018-05452-6

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Blood lipids influence DNA methylation in circulating cells

Publikováno v: Genome Biol
Genome Biology, 17(138), 1-12. Springer Verlag
Genome Biology, 17. BioMed Central
Genome Biology
Dekkers, K F, van Iterson, M, Slieker, R C, Moed, M H, Bonder, M J, van Galen, M, Mei, H, Zhernakova, D V, Van den Berg, L H, Deelen, J, van Dongen, J, van Heemst, D, Hofman, A, Hottenga, J J, van der Kallen, C J H, Schalkwijk, C G, Stehouwer, C D A, Tigchelaar, E F, Uitterlinden, A G, Willemsen, G, Zhernakova, A, Franke, L, 't Hoen, P A C, Jansen, R, van Meurs, J, Boomsma, D I, van Duijn, C M, van Greevenbroek, M M J, Veldink, J H, Wijmenga, C, van Zwet, E W, Slagboom, P E, Jukema, J W & Heijmans, B T 2016, ' Blood lipids influence DNA methylation in circulating cells ', Genome Biology, vol. 17, no. 138, pp. 1-12 . https://doi.org/10.1186/s13059-016-1000-6
Genome Biology (Online), 17:135. BioMed Central Ltd
Genome Biology, 17:138
Genome Biology, 17
Dekkers, K F, van Iterson, M, Slieker, R C, Moed, M H, Bonder, M J, van Galen, M, Mei, H, Zhernakova, D V, van den Berg, L H, Deelen, J, van Dongen, J, van Heemst, D, Hofman, A, Hottenga, J J, van der Kallen, C J H, Schalkwijk, C G, Stehouwer, C D A, Tigchelaar, E F, Uitterlinden, A G, Willemsen, G, Zhernakova, A, Franke, L, 't Hoen, P A C, Jansen, R, van Meurs, J, Boomsma, D I, van Duijn, C M, van Greevenbroek, M M J, Veldink, J H, Wijmenga, C, van Zwet, E W, Slagboom, P E, Jukema, J W & Heijmans, B T 2016, ' Blood lipids influence DNA methylation in circulating cells ', Genome Biology, vol. 17 . https://doi.org/10.1186/s13059-016-1000-6
Genome Biology, 17:138. BMC
Genome Biology, 17. BioMed Central Ltd.

Background Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b356b0d6fc72b2c4c593b8c0af0d37ba
https://hdl.handle.net/21.11116/0000-000B-7170-7

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Publikováno v: Genome Biology, 17. BioMed Central Ltd.
Genome Biology, 17:191
Genome Biology, 17
Genome Biology, 17. BioMed Central
Slieker, R C, van Iterson, M, Luijk, R, Beekman, M, Zhernakova, D V, Moed, M H, Mei, H, van Galen, M, Deelen, P, Bonder, M J, Zhernakova, A, Uitterlinden, A G, Tigchelaar, E F, Stehouwer, C D A, Schalkwijk, C G, van der Kallen, C J H, Hofman, A, van Heemst, D, de Geus, E J C, van Dongen, J, Deelen, J, Van den Berg, L H, van Meurs, J, Jansen, R, 't Hoen, P A C, Franke, L, Wijmenga, C, Veldink, J H, Swertz, M A, van Greevenbroek, M M J, van Duijn, C M, Boomsma, D I, Slagboom, P E & Heijmans, B T 2016, ' Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms ', Genome Biology, vol. 17, no. 191, pp. 1-13 . https://doi.org/10.1186/s13059-016-1053-6
Genome Biology
Genome Biology, 17:191. BMC
Genome Biol
Genome Biology (Online), 17:191. BioMed Central Ltd
Genome Biology, 17(191), 1-13. Springer Verlag
Slieker, R C, van Iterson, M, Luijk, R, Beekman, M, Zhernakova, D V, Moed, M H, Mei, H, van Galen, M, Deelen, P, Bonder, M J, Zhernakova, A, Uitterlinden, A G, Tigchelaar, E F, Stehouwer, C D A, Schalkwijk, C G, van der Kallen, C J H, Hofman, A, van Heemst, D, de Geus, E J, van Dongen, J, Deelen, J, van den Berg, L H, van Meurs, J, Jansen, R, 't Hoen, P A C, Franke, L, Wijmenga, C, Veldink, J H, Swertz, M A, van Greevenbroek, M M J, van Duijn, C M, Boomsma, D I, Slagboom, P E & Heijmans, B T 2016, ' Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms ', Genome Biology, vol. 17 . https://doi.org/10.1186/s13059-016-1053-6

Background Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in humans remains poorly understood. While DNA methylation at many CpG sites closely tracks chronological age, DNA methylation changes relevant to biological age a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8888316b49ead500ebe835779e5477d3
https://hdl.handle.net/1765/93446

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