Dextran–methylprednisolone succinate as a prodrug of methylprednisolone: Plasma and tissue disposition**A preliminary account of this study was presented at the Twelfth Annual Meeting of the American Association of Pharmaceutical Sciences, Boston, MA, November 2–6, 1997 (Mehvar R. 1997. Targeted delivery of methylprednisolone using a dextran prodrug. Pharm Res 14:S336)

Autor: Xiaoping Zhang, Reza Mehvar

Publikováno v: Journal of Pharmaceutical Sciences. 90:2078-2087

Plasma and tissue disposition of a macromolecular prodrug of methylprednisolone (MP), dextran (70 kDa)–methylprednisolone succinate (DMP), was studied in rats. Single 5‐mg/kg doses of DMP or unconjugated MP were administered into the tail veins o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc359ee47b117268617c0ccda884d946
https://doi.org/10.1002/jps.1158

Dextran–methylprednisolone succinate as a prodrug of methylprednisolone: Plasma and tissue disposition*A preliminary account of this study was presented at the Twelfth Annual Meeting of the American Association of Pharmaceutical Sciences, Boston, MA, November 2–6, 1997 (Mehvar R. 1997. Targeted delivery of methylprednisolone using a dextran prodrug. Pharm Res 14:S336).

Autor: Zhang, Xiaoping, Mehvar, Reza

Publikováno v: Journal of Pharmaceutical Sciences; December 2001, Vol. 90 Issue: 12 p2078-2087, 10p

Differential expression and activities of cytochrome P450 3A in the rat brain microsomes and mitochondria.

Autor: Alshammari N; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Chandrashekar DV; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Rashid M; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Mehvar R; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA.

Publikováno v: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2023 Apr; Vol. 37 (2), pp. 359-368. Date of Electronic Publication: 2022 Nov 17.

A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance and Efflux of Sucrose and Mannitol after IV Injection in Awake Mice.

Autor: Noorani B; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.; Center for Blood-Brain Barrier Research, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA., Chowdhury EA; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.; Center for Blood-Brain Barrier Research, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA.; Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, 14214, USA., Alqahtani F; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.; Center for Blood-Brain Barrier Research, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA.; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia., Sajib MS; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.; Center for Blood-Brain Barrier Research, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA.; Food and Drug Administration, Silver Spring, Maryland, 20903, USA., Ahn Y; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.; Center for Blood-Brain Barrier Research, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA., Nozohouri E; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.; Center for Blood-Brain Barrier Research, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA., Patel D; LC-MS Core Facility, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA., Mikelis C; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA.; Center for Blood-Brain Barrier Research, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA.; Department of Pharmacy, University of Patras, 26504, Patras, Greece., Mehvar R; Center for Blood-Brain Barrier Research, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA. mehvar@chapman.edu.; Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Rinker Health Science Campus, 9401 Jeronimo Road, Irvine, California, 92618, USA. mehvar@chapman.edu., Bickel U; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S Coulter St., Amarillo, Texas, 79106, USA. Ulrich.Bickel@ttuhsc.edu.; Center for Blood-Brain Barrier Research, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, 79106, USA. Ulrich.Bickel@ttuhsc.edu.

Publikováno v: Pharmaceutical research [Pharm Res] 2022 Feb; Vol. 39 (2), pp. 251-261. Date of Electronic Publication: 2022 Feb 10.

Development and validation of an ultrahigh-performance liquid chromatography-tandem mass spectrometry method to investigate the plasma pharmacokinetics of a K Ca 2.2/K Ca 2.3 positive allosteric modulator in mice.

Autor: Rahman MA; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Chandrashekar DV; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Nam YW; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Syed B; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Salehi D; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Aliabadi HM; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Zhang M; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA., Mehvar R; Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California, USA.

Publikováno v: Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2023 Aug 15; Vol. 37 (15), pp. e9537.