Výsledky vyhledávání - "Mehtap Uysal"

Akademický článek

Synthesis and biological evaluation of new 3(2H)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells

Autor: Zeynep Özdemir, Semra Utku, Bijo Mathew, Simone Carradori, Giustino Orlando, Simonetta Di Simone, Mehmet Abdullah Alagöz, Azime Berna Özçelik, Mehtap Uysal, Claudio Ferrante

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1100-1109 (2020)

Novel 3(2H)-pyridazinone derivatives were designed, synthesised in satisfactory yields and evaluated in different experimental assays to assess their preliminary toxicity in vivo and anti-proliferative effects against HCT116 cell lines in vitro. Arte

Externí odkaz: https://doaj.org/article/77aec80aff0d46378d800e0973455166

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Synthesis, Cytotoxicity and Anti-Proliferative Activity against AGS Cells of New 3(2H)-Pyridazinone Derivatives Endowed with a Piperazinyl Linker

Autor: Mehmet Abdullah Alagöz, Zeynep Özdemir, Mehtap Uysal, Simone Carradori, Marialucia Gallorini, Alessia Ricci, Susi Zara, Bijo Mathew

Publikováno v: Pharmaceuticals, Vol 14, Iss 3, p 183 (2021)

Novel twenty-three 3(2H)-pyridazinone derivatives were designed and synthesized based on the chemical requirements related to the anti-proliferative effects previously demonstrated within this scaffold. The introduction of a piperazinyl linker betwee

Externí odkaz: https://doaj.org/article/47501730cd0f45b3b1533e2d93a2d506

Zobrazit plný text záznamu

Akademický článek

Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors

Autor: Muhammed Çeçen, Jong Min Oh, Zeynep Özdemir, Saliha Ebru Büyüktuncel, Mehtap Uysal, Mohamed A. Abdelgawad, Arafa Musa, Nicola Gambacorta, Orazio Nicolotti, Bijo Mathew, Hoon Kim

Publikováno v: Molecules, Vol 25, Iss 22, p 5371 (2020)

Twelve pyridazinones (T1–T12) containing the (2-fluorophenyl) piperazine moiety were designed, synthesized, and evaluated for monoamine oxidase (MAO) -A and -B inhibitory activities. T6 was found to be the most potent MAO-B inhibitor with an IC50 v

Externí odkaz: https://doaj.org/article/d9e42791673e47f99076869696c536a7

Zobrazit plný text záznamu

Plný text ve formátu HTML

Synthesis of ( p‐ tolyl)‐3(2 H )pyridazinone Derivatives as Novel Acetylcholinesterase Inhibitors

Autor: İrem Bozbey Merde, Gülce Taşkor Önel, Burçin Türkmenoğlu, Şule Gürsoy, Esra Dilek, Azime Berna Özçelik, Mehtap Uysal

Publikováno v: ChemistrySelect. 7

In this study, a series of N-substituted-(p-tolyl)pyridazin-3(2H)-one derivatives were synthesized and evaluated for their AChE inhibitory activity. The chemical structures of novel compounds 5(a-m) were confirmed by H-1-NMR, C-13-NMR, IR and HRMS an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a868ee43c60e51161cc8611584d8bf
https://doi.org/10.1002/slct.202201606

Zobrazit plný text záznamu

Synthesis and biological evaluation of new 3(2H)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells

Autor: Mehmet Abdullah Alagöz, Claudio Ferrante, Bijo Mathew, Zeynep Özdemir, Mehtap Uysal, Azime Berna Özçelik, Semra Utku, Giustino Orlando, Simone Carradori, Simonetta Cristina Di Simone

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1100-1109 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0062253c4f10c00469b65d25e05701df
https://doi.org/10.1080/14756366.2020.1755670

Zobrazit plný text záznamu

Plný text ve formátu HTML

A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies

Autor: Azime Berna Özçelik, Semra Utku, Mehtap Uysal, Suat Sari, Zeynep Özdemir

Publikováno v: Pharmacological Reports. 71:1253-1263

Background The pyridazinone nucleus has been incorporated into a wide variety of therapeutically interesting molecules to transform them into better drugs. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6c9e8ddd4e414e6465315dbd332cb4
https://doi.org/10.1016/j.pharep.2019.07.006

Zobrazit plný text záznamu

3(2H)-pyridazinone derivatives: Synthesis, in-silico studies, structure-activity relationship and in-vitro evaluation for acetylcholinesterase enzyme inhibition

Autor: Ömer Faruk Çöl, İrem Bozbey, Burçin Türkmenoğlu, Mehtap Uysal

Publikováno v: Journal of Molecular Structure. 1261:132970

New ten compounds bearing pyridazinone ring (5a -j) were designed and synthesized as acetyl-cholinesterase inhibitors. The new derivatives were acquired via the reaction of propionohydrazides with substituted/nonsubstituted sulphonylchlorides. The st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28994336db989ab1fa86dc05d95e3e7
https://doi.org/10.1016/j.molstruc.2022.132970

Zobrazit plný text záznamu

Synthesis, Cytotoxicity and Anti−Proliferative Activity Against AGS Cells of New 3(2H)−Pyridazinone Derivatives Endowed with a Piperazinyl Linker

Autor: Simone Carradori, Bijo Mathew, Mehtap Uysal, Alessia Ricci, Zeynep Özdemir, Susi Zara, Mehmet Abdullah Alagöz, Marialucia Gallorini

Publikováno v: Pharmaceuticals, Vol 14, Iss 183, p 183 (2021)
Pharmaceuticals
Volume 14
Issue 3

Novel twenty−three 3(2H)−pyridazinone derivatives were designed and synthesized based on the chemical requirements related to the anti−proliferative effects previously demonstrated within this scaffold. The introduction of a piperazinyl linker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95170524a2472e5788952ff6e546e247
https://www.mdpi.com/1424-8247/14/3/183

Zobrazit plný text záznamu

Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors

Autor: Hoon Kim, Nicola Gambacorta, Bijo Mathew, Orazio Nicolotti, Jong Min Oh, Muhammed Çeçen, Mehtap Uysal, Arafa Musa, Saliha Ebru Büyüktuncel, Mohamed A. Abdelgawad, Zeynep Özdemir

Publikováno v: Molecules, Vol 25, Iss 5371, p 5371 (2020)
Molecules
Volume 25
Issue 22

Twelve pyridazinones (T1&ndash
T12) containing the (2-fluorophenyl) piperazine moiety were designed, synthesized, and evaluated for monoamine oxidase (MAO) -A and -B inhibitory activities. T6 was found to be the most potent MAO-B inhibitor with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2090dd451371f9b2b46b0000b92cb7d1
https://www.mdpi.com/1420-3049/25/22/5371

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání