Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mehrshad Sadria"'
Publikováno v:
Cell Reports: Methods, Vol 4, Iss 7, Pp 100819- (2024)
Summary: Cell reprogramming, which guides the conversion between cell states, is a promising technology for tissue repair and regeneration, with the ultimate goal of accelerating recovery from diseases or injuries. To accomplish this, regulators must
Externí odkaz:
https://doaj.org/article/1b081d4daa634d7781b59570237b81f7
Autor:
Anita T. Layton, Mehrshad Sadria
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract A year after the initial wild-type Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) strains began their devastation of the world, they were supplanted by new variants of concern (VOC). In Ontario, Canada, the wild type was overta
Externí odkaz:
https://doaj.org/article/b194bcd19ef74b4f80d17590b24af175
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-16 (2022)
Abstract Background Nutrient acquisition and metabolism pathways are altered in cancer cells to meet bioenergetic and biosynthetic demands. A major regulator of cellular metabolism and energy homeostasis, in normal and cancer cells, is AMP-activated
Externí odkaz:
https://doaj.org/article/dc2c9688a13745f3bd53809b6540b46b
Autor:
Mehrshad Sadria, Anita T. Layton
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background Cells adapt their metabolism and activities in response to signals from their surroundings, and this ability is essential for their survival in the face of perturbations. In tissues a deficit of these mechanisms is commonly associ
Externí odkaz:
https://doaj.org/article/e6babc6e51a2401cb9cf1d22147f689f
Autor:
Mehrshad Sadria, Anita T. Layton
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102245- (2021)
Summary: Aging is associated with impairments in the circadian rhythms, and with energy deregulation that affects multiple metabolic pathways. The goal of this study is to unravel the complex interactions among aging, metabolism, and the circadian cl
Externí odkaz:
https://doaj.org/article/9c4b90c0a5d344239b002408246a51c0
Autor:
Mehrshad Sadria, Anita T Layton
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 10, p e1008235 (2020)
Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) are frequently prescribed for a range of diseases including hypertension, proteinuric chronic kidney disease, and heart failure. There is evidence indicating t
Externí odkaz:
https://doaj.org/article/3e3ff97b25c6458f84eddc8ac10e17ed
Autor:
Mehrshad Sadria, Anita T. Layton
Publikováno v:
Viruses, Vol 13, Iss 6, p 1141 (2021)
The goal of this study was to develop a mathematical model to simulate the actions of drugs that target SARS-CoV-2 virus infection. To accomplish that goal, we have developed a mathematical model that describes the control of a SARS-CoV-2 infection b
Externí odkaz:
https://doaj.org/article/0e64ce52d2ec4db0b19c7804b793f4ca
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F274-F286
Sex influences cardiovascular disease, and the timing of onset of acute cardiovascular events exhibits circadian rhythms. Kidney function also exhibits sex differences and circadian rhythms. How do the natriuretic and diuretic effects of diuretics, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0962cf723ba25b9844b9caadd29419a3
https://doi.org/10.1152/ajprenal.00296.2022
https://doi.org/10.1152/ajprenal.00296.2022
For predictive computational models to be considered reliable in crucial areas such as biology and medicine, it is essential for them to be accurate, robust, and interpretable. A sufficiently robust model should not have its output affected significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68e7b9300aca176dd7c076a8e4faca26
https://doi.org/10.1101/2023.05.17.541170
https://doi.org/10.1101/2023.05.17.541170
Autor:
Mehrshad Sadria, Petter Bjornstad, Prasad Pottumarthi, Li Lu-Ping, Laura Pyle, Timothy Vigers, Anita Layton
Publikováno v:
Physiology. 38
Early diabetic kidney disease (DKD) is common in young persons with type 1 (T1D) and type 2 diabetes (T2D) and accentuates their lifetime risk of kidney failure, requiring dialysis or a kidney transplant. Although clinical manifestations of DKD are s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75ab5a61dd61a6ef1ba44846b82d66d7
https://doi.org/10.1152/physiol.2023.38.s1.5695980
https://doi.org/10.1152/physiol.2023.38.s1.5695980