Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Mehrnaz Gharaee‐Kermani"'
Autor:
Feiyang Ma, Pei-Suen Tsou, Mehrnaz Gharaee-Kermani, Olesya Plazyo, Xianying Xing, Joseph Kirma, Rachael Wasikowski, Grace A. Hile, Paul W. Harms, Yanyun Jiang, Enze Xing, Mio Nakamura, Danielle Ochocki, William D. Brodie, Shiv Pillai, Emanual Maverakis, Matteo Pellegrini, Robert L. Modlin, John Varga, Lam C. Tsoi, Robert Lafyatis, J. Michelle Kahlenberg, Allison C. Billi, Dinesh Khanna, Johann E. Gudjonsson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to fibrosis of skin and other internal organs. However, the main cellular participants in SS
Externí odkaz:
https://doaj.org/article/3b5a5e9a32fc4187b638ed4405b8d22c
Autor:
Feiyang Ma, Mehrnaz Gharaee-Kermani, Amy Hurst, J Michelle Kahlenberg, Mitra P Maz, Amanda M Victory, Johann Gudjonsson
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)
Externí odkaz:
https://doaj.org/article/2f3fc1c3191d4016bbb89aea90602f7e
Autor:
Shannon N. Loftus, Mehrnaz Gharaee-Kermani, Bin Xu, Tyson M. Moore, Andrew Hannoudi, Mischa J. Mallbris, Benjamin Klein, Johann E. Gudjonsson, J. Michelle Kahlenberg
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionUltraviolet (UV) light is a known trigger of both cutaneous and systemic disease manifestations in lupus patients. Lupus skin has elevated expression of type I interferons (IFNs) that promote increased keratinocyte (KC) death after UV exp
Externí odkaz:
https://doaj.org/article/2688932f602c4078829249e84a14bb01
Autor:
Feiyang Ma, Olesya Plazyo, Allison C. Billi, Lam C. Tsoi, Xianying Xing, Rachael Wasikowski, Mehrnaz Gharaee-Kermani, Grace Hile, Yanyun Jiang, Paul W. Harms, Enze Xing, Joseph Kirma, Jingyue Xi, Jer-En Hsu, Mrinal K. Sarkar, Yutein Chung, Jeremy Di Domizio, Michel Gilliet, Nicole L. Ward, Emanual Maverakis, Eynav Klechevsky, John J. Voorhees, James T. Elder, Jun Hee Lee, J. Michelle Kahlenberg, Matteo Pellegrini, Robert L. Modlin, Johann E. Gudjonsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin, is incompletely understood. Here we demonstrate, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A a
Externí odkaz:
https://doaj.org/article/7d7e27df0a374d5eb3a7f42f1d8c5e5f
Autor:
Ranjitha Uppala, Mrinal K. Sarkar, Kelly Z. Young, Feiyang Ma, Pritika Vemulapalli, Rachael Wasikowski, Olesya Plazyo, William R. Swindell, Emanual Maverakis, Mehrnaz Gharaee-Kermani, Allison C. Billi, Lam C. Tsoi, J. Michelle Kahlenberg, Johann E. Gudjonsson
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108986- (2024)
Summary: Interferon (IFN) activity exhibits a gender bias in human skin, skewed toward females. We show that HERC6, an IFN-induced E3 ubiquitin ligase, is induced in human keratinocytes through the epidermal type I IFN; IFN-κ. HERC6 knockdown in hum
Externí odkaz:
https://doaj.org/article/87cba07b11fb49b59bbc593a99230d5e
Autor:
Enze Xing, Feiyang Ma, Rachael Wasikowski, Allison C. Billi, Mehrnaz Gharaee-Kermani, Jennifer Fox, Craig Dobry, Amanda Victory, Mrinal K. Sarkar, Xianying Xing, Olesya Plazyo, Henry W. Chen, Grant Barber, Heidi Jacobe, Pei-Suen Tsou, Robert L. Modlin, John Varga, J. Michelle Kahlenberg, Lam C. Tsoi, Johann E. Gudjonsson, Dinesh Khanna
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Pansclerotic morphea (PSM) is a rare, devastating disease characterized by extensive soft tissue fibrosis, secondary contractions, and significant morbidity. PSM pathogenesis is unknown, and aggressive immunosuppressive treatments rarely slow disease
Externí odkaz:
https://doaj.org/article/40503665b3474f938f778ca913681263
Autor:
Shannon N. Loftus, Jianhua Liu, Celine C. Berthier, Johann E. Gudjonsson, Mehrnaz Gharaee-Kermani, Lam C. Tsoi, J. Michelle Kahlenberg
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Aberrant activation of the innate immune system is a known driver of lupus pathogenesis. Inhibition of the inflammasome and its downstream signaling components in murine models of lupus has been shown to reduce the severity of disease. Interleukin-1
Externí odkaz:
https://doaj.org/article/aa064b19d56a431ba58940d74183f8e1
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Background Lower urinary tract symptoms (LUTS) are a costly and pervasive medical problem for millions of aging men. Recent studies have showed that peri-urethral tissue fibrosis is an untreated pathobiology contributing to LUTS. Fibrosis results fro
Externí odkaz:
https://doaj.org/article/4b989bdefb3841798a2466b757ed984c
Autor:
Lam C Tsoi, Allison C Billi, Rachael Wasikowski, Johann E Gudjonsson, Feiyang Ma, Olesya Plazyo, Mehrnaz Gharaee-Kermani, Amy Hurst, Craig J Dobry, J Michelle Kahlenberg
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/bb91a219ba984f30aa738dc5923f089d
Autor:
Lam C. Tsoi, Mehrnaz Gharaee-Kermani, Celine C. Berthier, Tori Nault, Grace A. Hile, Shannon N. Estadt, Matthew T. Patrick, Rachael Wasikowski, Allison C. Billi, Lori Lowe, Tamra J. Reed, Johann E. Gudjonsson, J. Michelle Kahlenberg
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Skin lesions in dermatomyositis (DM) are common, are frequently refractory, and have prognostic significance. Histologically, DM lesions appear similar to cutaneous lupus erythematosus (CLE) lesions and frequently cannot be differentiated. We thus co
Externí odkaz:
https://doaj.org/article/fd0646f65bf54b9192f6285fd6af4db4