Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mehrdad Rahmaniyan"'
Autor:
Stefka D. Spassieva, Mehrdad Rahmaniyan, Jacek Bielawski, Christopher J. Clarke, Jacqueline M. Kraveka, Lina M. Obeid
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 5, Pp 918-928 (2012)
We applied a metabolic approach to investigate the role of sphingolipids in cell density-induced growth arrest in neuroblastoma cells. Our data revealed that sphingolipid metabolism in neuroblastoma cells significantly differs depending on the cells
Externí odkaz:
https://doaj.org/article/d076b921121046199bd366ade34e2c59
Autor:
Jacek Bielawski, Mehrdad Rahmaniyan, Duska Separovic, Alicja Bielawska, Jason S. Pierce, Mladen Korbelik, Kezhong Zhang, Jacqueline M. Kraveka, Jeremy S. DeLor, Li Li, Nithin B. Boppana
Publikováno v:
Anticancer Research. 37:455-464
Background/aim Combining an anticancer agent fenretinide (HPR) or C6-pyridinium ceramide (LCL29) with Foscan-mediated photodynamic therapy (FoscanPDT) is expected to augment anticancer benefits of each substance. We showed that treatment with FoscanP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29c9eed7c8ee03bc61f9d8395d3cd98
https://doi.org/10.21873/anticanres.11337
https://doi.org/10.21873/anticanres.11337
Autor:
Yusuf A. Hannun, Mehrdad Rahmaniyan, Jacqueline M. Kraveka, Aiping Bai, Jacek Bielawski, Alicja Bielawska
Publikováno v:
Bioorganicmedicinal chemistry. 26(23-24)
The function of acid ceramidase (ACDase), whose congenital deficiency leads to Farber disease, has been recognized to be vital to tumor cell biology, and inhibition of its activity may be beneficial in cancer therapy. Therefore, manipulation of the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299ee99015f0e89cedc641f4bccd2ec4
https://pubmed.ncbi.nlm.nih.gov/30448190
https://pubmed.ncbi.nlm.nih.gov/30448190
Autor:
Paul Breen, Jacqueline M. Kraveka, Nithin B. Boppana, Jason S. Pierce, Li Li, Mehrdad Rahmaniyan, Jacek Bielawski, Nicholas Joseph, Mladen Korbelik, Aiping Bai, Alicja Bielawska, Tatyana I. Gudz, Eric Van Buren, Duska Separovic
Publikováno v:
International Journal of Oncology
Photodynamic therapy (PDT) is not always effective as an anticancer treatment, therefore, PDT is combined with other anticancer agents for improved efficacy. The combination of dasatinib and PDT with the silicone phthalocyanine photosensitizer Pc 4 w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490a636f5ab1cb010175ec9c0b1a3b0d
https://doi.org/10.3892/ijo.2013.2132
https://doi.org/10.3892/ijo.2013.2132
Autor:
Jacqueline M. Kraveka, Lina M. Obeid, Mehrdad Rahmaniyan, Stefka D. Spassieva, Christopher J. Clarke, Jacek Bielawski
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 5, Pp 918-928 (2012)
We applied a metabolic approach to investigate the role of sphingolipids in cell density-induced growth arrest in neuroblastoma cells. Our data revealed that sphingolipid metabolism in neuroblastoma cells significantly differs depending on the cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a55f15d73f5d5f9a7385de035e912b8
https://doi.org/10.1194/jlr.m019075
https://doi.org/10.1194/jlr.m019075
Publikováno v:
Journal of Biological Chemistry. 286:24754-24764
The dihydroceramide desaturase (DES) enzyme is responsible for inserting the 4,5-trans-double bond to the sphingolipid backbone of dihydroceramide. We previously demonstrated that fenretinide (4-HPR) inhibited DES activity in SMS-KCNR neuroblastoma c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca73c30d0a83117422b7c9a85038a29
https://doi.org/10.1074/jbc.m111.250779
https://doi.org/10.1074/jbc.m111.250779
Autor:
Michael B. Lilly, E. Ellen Jones, Ping Lu, Heather Venant, Jacqueline M. Kraveka, Christina Voelkel-Johnson, Mehrdad Rahmaniyan, Richard R. Drake, Elizabeth Garrett-Mayer, Charles D. Smith
Publikováno v:
Molecular cancer therapeutics. 14(12)
Despite recent advances in the development of novel therapies against castration-resistant prostate cancer, the advanced form of the disease remains a major treatment challenge. Aberrant sphingolipid signaling through sphingosine kinases and their pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70212efddfd455efbd9e43be50dc321d
https://pubmed.ncbi.nlm.nih.gov/26494858
https://pubmed.ncbi.nlm.nih.gov/26494858
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 288:E753-E760
Studies were performed to further characterize the male-specific hepatic recombinant microsomal vitamin D 25-hydroxlase CYP2C11, expressed in baculovirus-infected insect cells, and determine whether it is also a vitamin D 24-hydroxylase. 25- and 24-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162fd84f7d40c0fc1ca497295a656a02
https://doi.org/10.1152/ajpendo.00201.2004
https://doi.org/10.1152/ajpendo.00201.2004
Autor:
Paul, Breen, Nicholas, Joseph, Kyle, Thompson, Jacqueline M, Kraveka, Tatyana I, Gudz, Li, Li, Mehrdad, Rahmaniyan, Jacek, Bielawski, Jason S, Pierce, Eric, VAN Buren, Gaurav, Bhatti, Duska, Separovic
Publikováno v:
Anticancer research. 33(1)
Dihydroceramide desaturase 1 (DES) is the enzyme responsible for converting dihydroceramide into ceramide in the de novo sphingolipid biosynthesis pathway. Dihydroceramide can inhibit ceramide channel formation to interfere with apoptosis. We have sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c49ef1b9d9f15bce5fdd4dd0b6dd9065
https://pubmed.ncbi.nlm.nih.gov/23267130
https://pubmed.ncbi.nlm.nih.gov/23267130
Publikováno v:
Cancer Research. 76:2479-2479
Background: Neuroblastoma is the most common solid tumor of infancy and third leading cause of cancer death in children. It has one of the lowest survival rates of all pediatric cancers with less than 50% survival in “high risk” disease. Curcumin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a95fdddd5282a17b6c8a005b15c1c049
https://doi.org/10.1158/1538-7445.am2016-2479
https://doi.org/10.1158/1538-7445.am2016-2479