Výsledky vyhledávání - "Mehran Modarres"

Akademický článek

Producing Integrase Minus Lentivirus for Transient Expression of the Desired Protein and Reduced Side Effects of the Virus in Gene Therapy

Autor: Laleh Shariati, Zahra Mohammadi, Zahra Hejazi, Mehran Modarres, Mansour Salehi, Mohammad Hossein Modarresi, Hossein Khanahmad

Publikováno v: مجله دانشکده پزشکی اصفهان, Vol 33, Iss 326, Pp 305-315 (2015)

Background: Lentiviral vectors are very efficient tools for gene therapy. But, proviral integration make their use dangerous; therefore, the safer integration deficient lentiviral vectors (IDLVs) can be produced through the use of integrase gene muta

Externí odkaz: https://doaj.org/article/d5cf551838ee4a8ab6a4df24e278047a

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Disruption of SOX6 gene using CRISPR/Cas9 technology for gamma-globin reactivation: An approach towards gene therapy of β-thalassemia

Autor: Zahra Hejazi, Mehran Modarres, Ina Laura Pieper, Shirin Kouhpayeh, Laleh Shariati, Mina Mirian, Hossein Khanahmad, Maryam Boshtam, Ilnaz Rahimmanesh, Fattah Rohani, Nahid Heidari Hafshejani

Publikováno v: Journal of cellular biochemistry. 119(11)

Elevation of Hemoglobin F ameliorates symptoms of β-thalassemia, a common autosomal recessive disorder. The transcription factor SOX6 plays a key role in the γ to β-globin gene switching. In the current investigation, a mutation was induced using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a8c9d3d11d99a60f36f96a2c72fedb
https://pubmed.ncbi.nlm.nih.gov/30010219

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