Výsledky vyhledávání - "Mehran Amoui"

Akademický článek

Targeted overexpression of osteoactivin in cells of osteoclastic lineage promotes osteoclastic resorption and bone loss in mice.

Autor: Matilda H-C Sheng, Jon E Wergedal, Subburaman Mohan, Mehran Amoui, David J Baylink, K-H William Lau

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35280 (2012)

This study sought to test whether targeted overexpression of osteoactivin (OA) in cells of osteoclastic lineage, using the tartrate-resistant acid phosphase (TRAP) exon 1B/C promoter to drive OA expression, would increase bone resorption and bone los

Externí odkaz: https://doaj.org/article/b54bd79cb2024f3d8bbbac41fd76d586

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Conditional Disruption ofmiR17∼92in Osteoclasts Led to Activation of Osteoclasts and Loss of Trabecular Bone in Part Through Suppression of themiR17-Mediated Downregulation of Protein-Tyrosine Phosphatase-oc in Mice

Autor: Jordan Tapia, Virginia Stiffel, Kin-Hing William Lau, Matilda H.-C. Sheng, Mehran Amoui, Tyler D White, Charles H. Rundle

Publikováno v: JBMR Plus. 1:73-85

This study sought to understand the regulation of an osteoclastic protein-tyrosine phosphatase (PTP-oc), a positive regulator of osteoclast activaty. Our past studies suggested that PTP-oc is regulated post-transcriptionally. The 3'-UTR of PTP-oc mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4d066379398aebc242f964798d9f5d6
https://doi.org/10.1002/jbm4.10014

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An Osteoclastic Transmembrane Protein-Tyrosine Phosphatase Enhances Osteoclast Activity in Part by Dephosphorylating EphA4 in Osteoclasts

Autor: Matilda H.-C. Sheng, Virginia Stiffel, Kin-Hing William Lau, Mehran Amoui, Shin-Tai Chen

Publikováno v: Journal of Cellular Biochemistry. 116:1785-1796

We have previously shown that PTP-oc is an enhancer of the functional activity of osteoclasts and that EphA4 is a suppressor. Here, we provide evidence that PTP-oc enhances osteoclast activity in part through inactivation of EphA4 by dephosphorylatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a29aa30265d440f960a84b46352e583d
https://doi.org/10.1002/jcb.25137

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EphA4 Receptor Is a Novel Negative Regulator of Osteoclast Activity

Autor: Virginia Stiffel, Mehran Amoui, K-H William Lau, Subburaman Mohan, Matilda H.-C. Sheng

Publikováno v: Journal of Bone and Mineral Research. 29:804-819

Of the ephrin (Eph) receptors, mature osteoclasts express predominantly EphA4. This study sought to determine if EphA4 has a regulatory role in osteoclasts. Treatment of RAW/C4 cells with Epha4 small interfering RNAs (siRNAs) increased average size,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd4881a51438eab08ff570cbbd84ee9c
https://doi.org/10.1002/jbmr.2084

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An osteoclastic protein-tyrosine phosphatase regulates the β3-integrin, syk, and shp1 signaling through respective src-dependent phosphorylation in osteoclasts

Autor: K.-H. William Lau, Mehran Amoui, Virginia Stiffel

Publikováno v: American Journal of Physiology-Cell Physiology. 302:C1676-C1686

This study utilized the glutathione transferase (GST) pull-down assay to identify novel substrates of an osteoclastic protein-tyrosine phosphatase, PTP-oc. Consistent with the previous findings that the phosphorylated tyr-527 (pY527) of Src is a subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29961f685ebfbcff78869df0a0f41f7
https://doi.org/10.1152/ajpcell.00042.2012

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Leptin Receptor (Lepr) Is a Negative Modulator of Bone Mechanosensitivity and Genetic Variations in Lepr May Contribute to the Differential Osteogenic Response to Mechanical Stimulation in the C57BL/6J and C3H/HeJ Pair of Mouse Strains

Autor: Sonia Kapur, Mehran Amoui, K.-H. William Lau, Xiaoguang Wang, Chandrasekhar Kesavan, Subburaman Mohan, David J. Baylink

Publikováno v: Journal of Biological Chemistry. 285:37607-37618

This study investigated the role of leptin receptor (Lepr) signaling in determining the bone mechanosensitivity and also evaluated whether differences in the Lepr signaling may contribute to the differential osteogenic response of the C57BL/6J (B6) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2dd85c2a13a5c3ab4de57f8cdc685e4
https://doi.org/10.1074/jbc.m110.169714

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Characterization and comparison of the intronic promoter of murine osteoclastic protein-tyrosine phosphatase, PTP-oc, with the human PTP-oc promoter

Autor: K.-H. William Lau, Donna D. Strong, Mehran Amoui, Jeannie H. Yang

Publikováno v: Archives of Biochemistry and Biophysics. 465:72-81

This study characterized the murine osteoclastic protein-tyrosine phosphatase (PTP-oc) promoter located within intron 12 of the Glepp1 gene. A 2-kb DNA fragment containing the putative intronic promoter showed strong promoter activity in pre-osteocla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ae83a4d6c106d2b2f7774f0da760e2
https://doi.org/10.1016/j.abb.2007.04.032

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A transmembrane osteoclastic protein-tyrosine phosphatase regulates osteoclast activity in part by promoting osteoclast survival through c-Src-dependent activation of NFκB and JNK2

Autor: Shin-Tai Chen, Mehran Amoui, K.-H. William Lau, Matilda H.-C. Sheng, David J. Baylink

Publikováno v: Archives of Biochemistry and Biophysics. 463:47-59

This study evaluated the effects of overexpression of wild-type (WT) or phosphatase-deficient (PD) mutant of an osteoclastic protein-tyrosine phosphatase (PTP-oc) in RAW/C4 cells. Osteoclast-like cells derived from WT-PTP-oc overexpressing clones inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05b74dd9b4d5864f7189c03980e9783
https://doi.org/10.1016/j.abb.2007.02.025

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Targeted deletion of the osteoclast protein-tyrosine phosphatase (PTP-oc) promoter prevents RANKL-mediated osteoclastic differentiation of RAW264.7 cells

Autor: Mehran Amoui, K.-H. William Lau, Jeannie H. Yang

Publikováno v: FEBS Letters. 581:2503-2508

An osteoclastic protein-tyrosine phosphatase, PTP-oc, shares the same gene with a renal PTP, Glepp1. This study demonstrated that targeted deletion of PTP-oc promoter by homologous recombination in RAW264.7 cells completely abolished PTP-oc expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521e95ac78f9f188c0d4c90ad3019227
https://doi.org/10.1016/j.febslet.2007.04.063

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Construction of a Tc1-like transposon Sleeping Beauty-based gene transfer plasmid vector for generation of stable transgenic mammalian cell clones

Autor: K.-H. William Lau, Joseph W Harris, Mehran Amoui, Donna D. Strong, David J. Baylink

Publikováno v: Analytical Biochemistry. 310:15-26

We have constructed a single plasmid-, Tc1-like transposon-based gene transfer vector, termed the Prince Charming vector (pPC). The pPC vector was constructed by ligating the CMV-driven "Sleeping Beauty" transposase gene downstream to the Tc1-like tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe8771e87d1df9eb4610e32d4c56550
https://doi.org/10.1016/s0003-2697(02)00316-0

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