Histone H3K4me3 breadth in hypoxia reveals endometrial core functions and stress adaptation linked to endometriosis

Autor: Kalle T. Rytkönen, Thomas Faux, Mehrad Mahmoudian, Taija Heinosalo, Mauris C. Nnamani, Antti Perheentupa, Matti Poutanen, Laura L. Elo, Günter P. Wagner

Publikováno v: iScience, Vol 25, Iss 5, Pp 104235- (2022)

Summary: Trimethylation of histone H3 at lysine 4 (H3K4me3) is a marker of active promoters. Broad H3K4me3 promoter domains have been associated with cell type identity, but H3K4me3 dynamics upon cellular stress have not been well characterized. We a

Externí odkaz: https://doaj.org/article/9dc03a5660ae47f3baf290543448e530

A predictive model of overall survival in patients with metastatic castration-resistant prostate cancer [version 2; peer review: 2 approved]

Autor: Mehrad Mahmoudian, Fatemeh Seyednasrollah, Liisa Koivu, Outi Hirvonen, Sirkku Jyrkkiö, Laura L. Elo

Publikováno v: F1000Research, Vol 5 (2019)

Metastatic castration resistant prostate cancer (mCRPC) is one of the most common cancers with a poor prognosis. To improve prognostic models of mCRPC, the Dialogue for Reverse Engineering Assessments and Methods (DREAM) Consortium organized a crowds

Externí odkaz: https://doaj.org/article/91388e2532dd4391bc24954296a2e9a7

Transcriptomic responses to hypoxia in endometrial and decidual stromal cells

Autor: Matti Poutanen, Xinghong Ma, Antti Perheentupa, Mehrad Mahmoudian, Günter P. Wagner, Kalle T. Rytkönen, Taija Heinosalo, Laura L. Elo

Publikováno v: Reproduction. 160:39-51

Human reproductive success depends on a properly decidualized uterine endometrium that allows implantation and the formation of the placenta. At the core of the decidualization process are endometrial stromal fibroblasts (ESF) that differentiate to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068d28279d1cd714bc65c0b84c97e05c
https://doi.org/10.1530/rep-19-0615

Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia

Autor: Kalle T Rytkönen, Nigatu Adossa, Mehrad Mahmoudian, Tapio Lönnberg, Matti Poutanen, Laura L Elo

Publikováno v: Reproduction (Cambridge, England). 164(5)

In brief Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia. Abstra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df72a5a2433627c032abf4c2264090a
https://pubmed.ncbi.nlm.nih.gov/36111648

A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection

Autor: Samad Jahandideh, Christopher Chiu, Slim Fourati, Motoki Shiga, Mehmet Eren Ahsen, Riku Klén, Laura L. Elo, Torbjörn E. M. Nordling, Solveig K. Sieberts, Joshua Burkhart, Xiao Liang, Ricardo Henao, Zafer Aydin, Gaurav Pandey, Reem Almugbel, Robert Vogel, Micah T. McClain, Ephraim L. Tsalik, Ana Stanescu, Christopher W. Woods, Thomas Yu, Geoffrey S. Ginsburg, Lara M. Mangravite, Ka Yee Yeung, Mehrad Mahmoudian, Aarthi Talla

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.4418. ⟨10.1038/s41467-018-06735-8⟩

The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictors from the early stages of infection. Here we conduct a community-based analysis to determine whether pre- or early post

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97b9fdf5452dce81e41b6db81478e5d
http://link.springer.com/article/10.1038/s41467-018-06735-8