Výsledky vyhledávání - "Mehmet U. Bikkul"

Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways

Autor: Ian R. Kill, Wendy Ofosu, Joanna M. Bridger, Craig S. Clements, Evgeny M. Makarov, David Tree, Christopher H. Eskiw, Mehmet U. Bikkul

Publikováno v: Biogerontology

Hutchinson–Gilford progeria syndrome (HGPS) is a rare, premature ageing syndrome in children. HGPS is normally caused by a mutation in the LMNA gene, encoding nuclear lamin A. The classical mutation in HGPS leads to the production of a toxic trunca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6b2fd09330521c2ec71ca71051a6af
http://europepmc.org/articles/PMC6535420

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Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform

Autor: Mehmet U, Bikkul, Richard G A, Faragher, Gemma, Worthington, Peter, Meinke, Alastair R W, Kerr, Aakila, Sammy, Kumars, Riyahi, Daniel, Horton, Eric C, Schirmer, Michael, Hubank, Ian R, Kill, Rhona M, Anderson, Predrag, Slijepcevic, Evgeny, Makarov, Joanna M, Bridger

Publikováno v: Genes, Chromosomes & Cancer

Immortalizing primary cells with human telomerase reverse transcriptase (hTERT) has been common practice to enable primary cells to be of extended use in the laboratory because they avoid replicative senescence. Studying exogenously expressed hTERT i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12e00fad84dd0aef28f333fa5384160a
https://pubmed.ncbi.nlm.nih.gov/30474255

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Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts

Autor: Mehmet U. Bikkul, Joanna M. Bridger, Craig S. Clements, Lauren S. Godwin, Ian R. Kill, Martin W. Goldberg

Publikováno v: Biogerontology
Biogerontology, 2018, Vol.19(6), pp.579-602 [Peer Reviewed Journal]

Hutchinson–Gilford progeria syndrome (HGPS) is a rare and fatal premature ageing disease in children. HGPS is one of several progeroid syndromes caused by mutations in the LMNA gene encoding the nuclear structural proteins lamins A and C. In classi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429d5898315377b4d14f0feadec93d82
https://pubmed.ncbi.nlm.nih.gov/29907918

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