Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.

Autor: Lisa Sanderson, Marcelo da Silva, Gayathri N Sekhar, Rachel C Brown, Hollie Burrell-Saward, Mehmet Fidanboylu, Bo Liu, Lea Ann Dailey, Cécile A Dreiss, Chris Lorenz, Mark Christie, Shanta J Persaud, Vanessa Yardley, Simon L Croft, Margarita Valero, Sarah A Thomas

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009276 (2021)

BackgroundHuman African trypanosomiasis (HAT or sleeping sickness) is caused by the parasite Trypanosoma brucei sspp. The disease has two stages, a haemolymphatic stage after the bite of an infected tsetse fly, followed by a central nervous system st

Externí odkaz: https://doaj.org/article/09b1e0c2a621449a9fa1562f25edd5f8

Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug

Autor: Sarah A. Thomas, Lea Ann Dailey, Marcelo A. da Silva, Lisa Sanderson, Shanta J. Persaud, Margarita Valero, Simon L. Croft, Mark R. Christie, Hollie Burrell-Saward, Mehmet Fidanboylu, Chris Lorenz, Bo Liu, Cécile A. Dreiss, Rachel C. Brown, Gayathri N. Sekhar, Vanessa Yardley

Publikováno v: PLoS Neglected Tropical Diseases
Sanderson, L, Da Silva, M, Sekhar, G, Brown, R, Burrell-Saward, H, Fidanboylu, M, Liu, B, Dailey, L A, Dreiss, C, Lorenz, C, Christie, M, Persaud, S, Yardley, V, Croft, S, Valero, M & Thomas, S 2021, ' Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug ', PLoS Neglected Tropical Diseases, vol. 15, no. 4, e0009276 . https://doi.org/10.1371/journal.pntd.0009276
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009276 (2021)

Background Human African trypanosomiasis (HAT or sleeping sickness) is caused by the parasite Trypanosoma brucei sspp. The disease has two stages, a haemolymphatic stage after the bite of an infected tsetse fly, followed by a central nervous system s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df891de01e7429062121850fdcf1fbae
https://doi.org/10.1371/journal.pntd.0009276

Delivery of Antihuman African Trypanosomiasis Drugs Across the Blood–Brain and Blood–CSF Barriers

Autor: Mehmet Fidanboylu, Gayathri N. Sekhar, Christopher P. Watson, Lisa Sanderson, Sarah A. Thomas

Human African trypanosomiasis (HAT or sleeping sickness) is a potentially fatal disease caused by the parasite, Trypanosoma brucei sp. The parasites are transmitted by the bite of insect vectors belonging to the genus Glossina (tsetse flies) and disp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee14fac9284c6e0526c60b97fcfb7db3
https://doi.org/10.1016/bs.apha.2014.06.003

Intercellular exchange of surface molecules and its physiological relevance

Autor: Mehmet Fidanboylu, Kathryn Brown, Wilson Wong

Publikováno v: Archivum immunologiae et therapiae experimentalis. 58(4)

For many decades, cellular immunologists have relied on the expression of various cell surface molecules to divide cells into different types and subtypes to study their function. However, in recent years, a large and fast-expanding body of work has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c3e49c35f950f6b19e3479b6693779
https://pubmed.ncbi.nlm.nih.gov/20508995

Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents

Autor: Anthony Wayne Orr, Abraham Al Ahmad, Boyeon Lee, Lisa D. Auckland, Mehmet Fidanboylu, Andrzej Fertala, Courtney Shaw, Gregory J. Bix, Christi Parham, Sarah A. Thomas, Omolara O. Ogunshola, Michael P. Kahle, Douglas Clarke

Publikováno v: Journal of Clinical Investigation. 122:777-777

Stroke is the leading cause of long-term disability and the third leading cause of death in the United States. While most research thus far has focused on acute stroke treatment and neuroprotection, the exploitation of endogenous brain self-repair me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eeb106d808fd26a0c2faa0c354c5b79
https://doi.org/10.1172/jci61899