Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mehmet E, Yalvac"'
Autor:
Kelly A. Rich, Megan G. Pino, Mehmet E. Yalvac, Ashley Fox, Hallie Harris, Maria H.H. Balch, W. David Arnold, Stephen J. Kolb
Publikováno v:
Neurobiology of Disease, Vol 182, Iss , Pp 106148- (2023)
Kinesin family member 5A (KIF5A) is an essential, neuron-specific microtubule-associated motor protein responsible for the anterograde axonal transport of various cellular cargos. Loss of function variants in the N-terminal, microtubule-binding domai
Externí odkaz:
https://doaj.org/article/cda27b4962784d7c8318bfefea38a90e
Autor:
Zarife Sahenk, Burcak Ozes, Darren Murrey, Morgan Myers, Kyle Moss, Mehmet E. Yalvac, Alicia Ridgley, Lei Chen, Jerry R. Mendell
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 401-414 (2021)
Limb girdle muscular dystrophy (LGMD) 2A/R1, caused by mutations in the CAPN3 gene and CAPN3 loss of function, is known to play a role in disease pathogenicity. In this study, AAVrh74.tMCK.CAPN3 was delivered systemically to two different age groups
Externí odkaz:
https://doaj.org/article/dc63800556e54ec48f051843902e5f99
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Gene editing of the mitochondrial genome using the CRISPR-Cas9 system is highly challenging mainly due to sub-efficient delivery of guide RNA and Cas9 enzyme complexes into the mitochondria. In this study, we were able to perform gene editing in the
Externí odkaz:
https://doaj.org/article/886fb15f6ef748c58834c5883e7c178f
Autor:
Mehmet E. Yalvac, Jakkrit Amornvit, Cilwyn Braganza, Lei Chen, Syed-Rehan A. Hussain, Kimberly M. Shontz, Chrystal L. Montgomery, Kevin M. Flanigan, Sarah Lewis, Zarife Sahenk
Publikováno v:
Skeletal Muscle, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract Background Previous studies in patients with limb-girdle muscular dystrophy type 2A (LGMD2A) have suggested that calpain-3 (CAPN3) mutations result in aberrant regeneration in muscle. Methods To gain insight into pathogenesis of aberrant mus
Externí odkaz:
https://doaj.org/article/1d7be0484ff545ed8f0fe8ea3ec7fc50
Autor:
Florian Kopp, Mahmoud M Elguindy, Mehmet E Yalvac, He Zhang, Beibei Chen, Frank A Gillett, Sungyul Lee, Sushama Sivakumar, Hongtao Yu, Yang Xie, Prashant Mishra, Zarife Sahenk, Joshua T Mendell
Publikováno v:
eLife, Vol 8 (2019)
Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here, we investigated the physiologic function of the conserved lncRNA Norad in vivo. Deletion of Norad in
Externí odkaz:
https://doaj.org/article/11ac600402c64f12aeffc40cfa19a3d5
Autor:
Lei Chen, Mehmet E. Yalvac, Alicia Ridgley, Darren Murrey, Kyle Moss, Jerry R. Mendell, Morgan Myers, Zarife Sahenk, Burcak Ozes
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss, Pp 401-414 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Limb girdle muscular dystrophy (LGMD) 2A/R1, caused by mutations in the CAPN3 gene and CAPN3 loss of function, is known to play a role in disease pathogenicity. In this study, AAVrh74.tMCK.CAPN3 was delivered systemically to two different age groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ed3cc6fa75414170186537cf89b0e8
https://doi.org/10.1016/j.omtm.2021.06.010
https://doi.org/10.1016/j.omtm.2021.06.010
Autor:
Florian, Kopp, Mahmoud M, Elguindy, Mehmet E, Yalvac, He, Zhang, Beibei, Chen, Frank A, Gillett, Sungyul, Lee, Sushama, Sivakumar, Hongtao, Yu, Yang, Xie, Prashant, Mishra, Zarife, Sahenk, Joshua T, Mendell
Publikováno v:
eLife
Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here, we investigated the physiologic function of the conserved lncRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b47d9e4ef15c8d3d42901a492acb7bc0
https://pubmed.ncbi.nlm.nih.gov/30848246
https://pubmed.ncbi.nlm.nih.gov/30848246
Autor:
Zarife, Sahenk, Mehmet E, Yalvac, Jakkrit, Amornvit, William David, Arnold, Lei, Chen, Kimberly M, Shontz, Sarah, Lewis
Publikováno v:
Brain and Behavior
Introduction Classic Charcot‐Marie‐Tooth (CMT) neuropathies including those with Schwann cell genetic defects exhibit a length‐dependent process affecting the distal axon. Energy deprivation in the distal axon has been the proposed mechanism ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a181a7909c123e7fadfd06aacf456735
https://pubmed.ncbi.nlm.nih.gov/30239155
https://pubmed.ncbi.nlm.nih.gov/30239155
Autor:
Amornvit, Jakkrit1,2, Yalvac, Mehmet E.1, Chen, Lei1, Sahenk, Zarife1,3,4 zarife.sahenk@nationwidechildrens.org
Publikováno v:
Brain & Behavior. Aug2017, Vol. 7 Issue 8, pn/a-N.PAG. 8p.
Coronary Artery Bypass Surgery Provokes Alzheimer's Disease-Like Changes in the Cerebrospinal Fluid.
Autor:
Palotás, András1, Reis, Helton J.2, Bogáts, Gábor3, Babik, Barna3,4, Racsmány, Mihály5,6, Engvau, Linda6,7, Kecskeméti, Éva6,7, Juhász, Anna7, Vieira, Luciene B.2, Teixeira, Antônio L.8, Mukhamedyarov, Marat A.9, Rizvanov, Albert A.10,11,12, Yalvaç, Mehmet E.12, Guimarêes, Melissa M.2,13, Ferreira, Cláudia N.13,14, Zefirov, Andrey L.9, Kiyasov, Andrey P.15, Wang, Lan16, Janka, Zoltán7, Kálmán, János7
Publikováno v:
Journal of Alzheimer's Disease. 2010, Vol. 21 Issue 4, p1153-1164. 12p.