The Therapeutic Potential of Ethnomedicinally Important Anatolian Thyme Species: A Phytochemical and Biological Assessment

Autor: Esra Eroglu Ozkan, Ezgi Ersoy, Yeter Yesil Canturk, Emel Mataraci Kara, Ercan Cinar, Hasan Sahin, Selim Karahan, Kubra Karaca Sancaktepe, Mustafa Abdullah Yilmaz, Mehmet Boga

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Thyme has been used for various therapeutic purposes in many different cultures, which makes it one of the most riveting medicinal plants throughout history. From its beneficial effects on the respiratory tract or the gastrointestinal system, to its

Externí odkaz: https://doaj.org/article/4627d7c65cda4ea697c56e0239a2dd82

Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile

Autor: Nabih Lolak, Mehmet Boga, Muhammed Tuneg, Gulcin Karakoc, Suleyman Akocak, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 424-431 (2020)

A series of 16 novel benzenesulfonamides incorporating 1,3,5-triazine moieties substituted with aromatic amines, dimethylamine, morpholine and piperidine were investigated. These compounds were assayed for antioxidant properties by using 1,1-diphenyl

Externí odkaz: https://doaj.org/article/e79e1240f39d4a6a98545ce1f7db7dab

Antioxidant and Anticholinesterase Potentials of Novel 4,6-Dimethoxyindole based Unsymmetrical Azines: Synthesis, Molecular Modeling, In Silico ADME Prediction and Biological Evaluations

Autor: Murat Bingul, Selami Ercan, Mehmet Boga, Alev Arslanturk Bingul

Publikováno v: Polycyclic Aromatic Compounds. :1-22

Chemically and biologically important -C = N-N = C- diimine linkage was used to build unsymmetrical azine systems with indole heterocyclic backbone and substituted aromatic carbaldehydes. Ten novel compounds 7a-j were synthesized by the Schiff base r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dccf81258c0f3fbc3b6908e951be900
https://doi.org/10.1080/10406638.2023.2193417

In Silico Studies and DNA Cleavage, Antioxidant, Acetylcholinesterase, and Butyrylcholinesterase Activity Evaluation of Bis-Histamine Schiff Bases and Bis-Spinaceamine Substituted Derivatives

Autor: Nebih Lolak, Mehmet Boga, Gorkem Deniz Sonmez, Muhammed Tuneg, Aslinur Dogan, Suleyman Akocak

Publikováno v: Pharmaceutical Chemistry Journal. 55:1338-1344

In this work, a series of seven bis-histamine Schiff bases (H1-H4) and bis-spinaceamine substituted derivatives (SPH1, SPH2, and SPH4) were successfully re-synthesized to evaluate their antioxidant properties by several bioanalytical methods such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f616ed3522eee7f65f5d72d580182097
https://doi.org/10.1007/s11094-022-02581-7

Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action

Autor: Erbay Kalay, Nebih Lolak, Suleyman Akocak, Mehmet Boga, Alessio Nocentini, Mustafa Yilmaz, Mehmet Oguz, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1215-1223 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry

A series of novel calix[4]azacrown substituted sulphonamide Schiff bases was synthesised by the reaction of calix[4]azacrown aldehydes with different substituted primary and secondary sulphonamides. The obtained novel compounds were investigated as i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bb147741e7f40954f448bb35b81ee0
https://doaj.org/article/0f89ebb89dde45aea88d26dfdb740011