769 System xCT as dermal fibrosis potentiator and new therapeutic target in systemic sclerosis

Autor: Tiemann, J., Mücklich, S., Leson, S., Haub, J., Kneilling, M., Mehling, R., Röcken, M., Schäfers, M., Backhaus, P., Schwegmann, K., Steinbrink, K., Raker, V.

Publikováno v: In Journal of Investigative Dermatology August 2024 144(8) Supplement:S134-S134

Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA.

Autor: Golombek S; Department of Thoracic and Cardiovascular Surgery, University Hospital Tübingen, Calwerstraße 7/1, 72076 Tübingen, Germany., Hoffmann T; Accanis Biotech, Karl-Farkas-Gasse 22, Vienna 1030, Austria., Hann L; Department of Thoracic and Cardiovascular Surgery, University Hospital Tübingen, Calwerstraße 7/1, 72076 Tübingen, Germany., Mandler M; Accanis Biotech, Karl-Farkas-Gasse 22, Vienna 1030, Austria., Schmidhuber S; Accanis Biotech, Karl-Farkas-Gasse 22, Vienna 1030, Austria., Weber J; Department of Thoracic and Cardiovascular Surgery, University Hospital Tübingen, Calwerstraße 7/1, 72076 Tübingen, Germany., Chang YT; Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea., Mehling R; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Röntgenweg 13, 72076 Tübingen, Germany., Ladinig A; University Clinic for Swine, Department of Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Veterinärplatz 1, Vienna 1210, Austria., Knecht C; University Clinic for Swine, Department of Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Veterinärplatz 1, Vienna 1210, Austria., Leyens J; Department of Thoracic and Cardiovascular Surgery, University Hospital Tübingen, Calwerstraße 7/1, 72076 Tübingen, Germany., Schlensak C; Department of Thoracic and Cardiovascular Surgery, University Hospital Tübingen, Calwerstraße 7/1, 72076 Tübingen, Germany., Wendel HP; Department of Thoracic and Cardiovascular Surgery, University Hospital Tübingen, Calwerstraße 7/1, 72076 Tübingen, Germany., Schneeberger A; Accanis Biotech, Karl-Farkas-Gasse 22, Vienna 1030, Austria., Avci-Adali M; Department of Thoracic and Cardiovascular Surgery, University Hospital Tübingen, Calwerstraße 7/1, 72076 Tübingen, Germany.

Publikováno v: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2023 Aug 02; Vol. 33, pp. 642-654. Date of Electronic Publication: 2023 Aug 02 (Print Publication: 2023).

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Acute and chronic inflammation alter immunometabolism in a cutaneous delayed-type hypersensitivity reaction (DTHR) mouse model.

Autor: Zizmare L; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tübingen, Röntgenweg 13, 72076, Tübingen, Germany., Mehling R; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tübingen, Röntgenweg 13, 72076, Tübingen, Germany., Gonzalez-Menendez I; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University of Tübingen, Röntgenweg 11, 72076, Tübingen, Germany.; Institute of Pathology and Neuropathology, Comprehensive Cancer Center, Eberhard Karls University of Tübingen, Liebermasterstraße 8, 72076, Tübingen, Germany., Lonati C; Center for Preclinical Research, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20100, Milan, Italy., Quintanilla-Martinez L; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University of Tübingen, Röntgenweg 11, 72076, Tübingen, Germany.; Institute of Pathology and Neuropathology, Comprehensive Cancer Center, Eberhard Karls University of Tübingen, Liebermasterstraße 8, 72076, Tübingen, Germany., Pichler BJ; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tübingen, Röntgenweg 13, 72076, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University of Tübingen, Röntgenweg 11, 72076, Tübingen, Germany., Kneilling M; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tübingen, Röntgenweg 13, 72076, Tübingen, Germany. Manfred.Kneilling@med.uni-tuebingen.de.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University of Tübingen, Röntgenweg 11, 72076, Tübingen, Germany. Manfred.Kneilling@med.uni-tuebingen.de.; Department of Dermatology, Eberhard Karls University of Tübingen, Liebermeisterstraße 25, 72076, Tübingen, Germany. Manfred.Kneilling@med.uni-tuebingen.de., Trautwein C; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tübingen, Röntgenweg 13, 72076, Tübingen, Germany. Christoph.Trautwein@med.uni-tuebingen.de.

Publikováno v: Communications biology [Commun Biol] 2022 Nov 15; Vol. 5 (1), pp. 1250. Date of Electronic Publication: 2022 Nov 15.

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