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Discovery of drugs to treat cytokine storm-induced cardiac dysfunction using human cardiac organoids

Autor: Mills, Richard J, Humphrey, Sean J, Fortuna, Patrick RJ, Quaife-Ryan, Gregory A, Mehdiabadi, Neda R, Devilée, Lynn, Voges, Holly K, Reynolds, Liam T, Krumeich, Sophie, Mathieson, Ellen, Griffen, Brendan, Titmarsh, Drew, Porrello, Enzo R, Smyth, Mark J, Engwerda, Christian R, MacDonald, Kelli PA, Bald, Tobias, James, David E, Hudson, James E

SUMMARY SARS-CoV2 infection leads to cardiac injury and dysfunction in 20-30% of hospitalized patients 1 and higher rates of mortality in patients with pre-existing cardiovascular disease 2,3 . Inflammatory factors released as part of the ‘cytokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______293::70e9c924b7cad3943b44969c56826b8d
https://hdl.handle.net/2123/23322

Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle.

Autor: McNamara JW; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Centre for Muscle Research, University of Melbourne, Melbourne, Victoria, Australia.; Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Parker BL; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Centre for Muscle Research, University of Melbourne, Melbourne, Victoria, Australia., Voges HK; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia.; School of Biomedical Sciences and Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia., Mehdiabadi NR; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.; Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia., Bolk F; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Ahmad F; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia.; Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Chung JD; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Centre for Muscle Research, University of Melbourne, Melbourne, Victoria, Australia., Charitakis N; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.; School of Biomedical Sciences and Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia., Molendijk J; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Zech ATL; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia.; Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Lal S; Precision Cardiovascular Laboratory, The University of Sydney, Sydney, New South Wales, Australia., Ramialison M; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.; Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Victoria, Australia.; School of Biomedical Sciences and Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.; Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia., Karavendzas K; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.; Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Pointer HL; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia., Syrris P; Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, UK.; Barts Heart Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK., Lopes LR; Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, UK.; Barts Heart Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK., Elliott PM; Centre for Heart Muscle Disease, Institute of Cardiovascular Science, University College London, London, UK.; Barts Heart Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK., Lynch GS; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Centre for Muscle Research, University of Melbourne, Melbourne, Victoria, Australia., Mills RJ; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.; Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Victoria, Australia.; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Hudson JE; Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Watt KI; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.; Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Porrello ER; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia. enzo.porrello@mcri.edu.au.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia. enzo.porrello@mcri.edu.au.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia. enzo.porrello@mcri.edu.au.; Centre for Muscle Research, University of Melbourne, Melbourne, Victoria, Australia. enzo.porrello@mcri.edu.au.; Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Victoria, Australia. enzo.porrello@mcri.edu.au., Elliott DA; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia. David.elliott@mcri.edu.au.; Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia. David.elliott@mcri.edu.au.; Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Victoria, Australia. David.elliott@mcri.edu.au.; School of Biomedical Sciences and Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia. David.elliott@mcri.edu.au.; Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia. David.elliott@mcri.edu.au.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2023 Feb; Vol. 2 (2), pp. 159-173. Date of Electronic Publication: 2023 Feb 15.