Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Mehdi Jorfi"'
Autor:
Eunkyung Clare Ko, Sarah Spitz, Francesca Michela Pramotton, Olivia M. Barr, Ciana Xu, Georgios Pavlou, Shun Zhang, Alice Tsai, Anna Maaser-Hecker, Mehdi Jorfi, Se Hoon Choi, Rudolph E. Tanzi, Roger D. Kamm
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
High failure rates in clinical trials for neurodegenerative disorders such as Alzheimer’s disease have been linked to an insufficient predictive validity of current animal-based disease models. This has created an increasing demand for alternative,
Externí odkaz:
https://doaj.org/article/5f0f854d8b8b434c9d0077855ad08b9d
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-25 (2023)
Abstract Alzheimer’s disease (AD) is a genetically complex and heterogeneous disorder with multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary tangles, and neuroinflammation. Over the past decade, emerging evidenc
Externí odkaz:
https://doaj.org/article/04a307d70ba44184986ccc34d85b0266
Autor:
Yousef Javanmardi, Ayushi Agrawal, Andrea Malandrino, Soufian Lasli, Michelle Chen, Somayeh Shahreza, Bianca Serwinski, Leila Cammoun, Ran Li, Mehdi Jorfi, Boris Djordjevic, Nicolas Szita, Fabian Spill, Sergio Bertazzo, Graham K Sheridan, Vivek Shenoy, Fernando Calvo, Roger Kamm, Emad Moeendarbary
Publikováno v:
Advanced Science, Vol 10, Iss 16, Pp n/a-n/a (2023)
Abstract Cancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest on the endothelium, transendothelial migration (TEM), followed by the invasion into the subendothelial extracellular matrix (ECM) of distant tissues
Externí odkaz:
https://doaj.org/article/28f88a3bdf124cc89be1eea1ffbeb641
Autor:
Madhura S. Lotlikar, Marina B. Tarantino, Mehdi Jorfi, Dora M. Kovacs, Rudolph E. Tanzi, Raja Bhattacharyya
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101028- (2022)
Summary: This protocol describes the differentiation of human neural progenitor cells (hNPCs) in a microfluidic device containing a thin 3D matrix with two separate chambers, enabling a cleaner separation between axons and soma/bulk neurons. We have
Externí odkaz:
https://doaj.org/article/a25e9442bd7a4c29810f9ee407228707
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, clinically defined by progressive cognitive decline and pathologically, by brain atrophy, neuroinflammation, and accumulation of extracellular amyloid plaques and intrace
Externí odkaz:
https://doaj.org/article/f4a01006966f4d98be06b139a3a558ed
Autor:
Raja Bhattacharyya, Sophia E. Black, Madhura S. Lotlikar, Rebecca H. Fenn, Mehdi Jorfi, Dora M. Kovacs, Rudolph E. Tanzi
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109134- (2021)
Summary: Axonal generation of Alzheimer’s disease (AD)-associated amyloid-β (Aβ) plays a key role in AD neuropathology, but the cellular mechanisms involved in its release have remained elusive. We previously reported that palmitoylated APP (palA
Externí odkaz:
https://doaj.org/article/fbb9f0ece7c448f19a3b11f957ce5278
Autor:
Mohammad Kooti, Mehdi Jorfi
Publikováno v:
E-Journal of Chemistry, Vol 5, Iss 2, Pp 365-369 (2008)
A variety of aromatic alcohols were efficiently oxidized to their corresponding aldehydes and ketones in good to excellent yields using nickel peroxide activated by acetic acid. Some thiols and amines were also readily oxidized by this oxidant under
Externí odkaz:
https://doaj.org/article/60d2c38f9e8b4b2cbd7e40cb1f2c5d16
Autor:
Rudolph E. Tanzi, Mehdi Jorfi, Raja Bhattacharyya, Dora M. Kovacs, Sophia E. Black, Madhura S. Lotlikar, Rebecca H. Fenn
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109134-(2021)
Cell reports
Cell reports
SUMMARY Axonal generation of Alzheimer’s disease (AD)-associated amyloid-β (Aβ) plays a key role in AD neuropathology, but the cellular mechanisms involved in its release have remained elusive. We previously reported that palmitoylated APP (palAP
Autor:
Ruslan I. Sadreyev, Claudio Vinegoni, Mehdi Jorfi, Benjamin P. Kleinstiver, Shun He, Se Hoon Choi, Yoshiko Iwamoto, Lai Ping Wong, Ralph Weissleder, Rudolph E. Tanzi, Christopher T. Chan, Sumnima Singh, Joseph Park, Florian Kahles, Ana Griciuc, Kathleen A. Christie, Atsushi Anzai, John E. Mindur, Filip K. Swirski, M. Kiss, Paolo Fumene Feruglio, Wolfram C. Poller, Eunhee Kim, Matthias Nahrendorf, Jeffrey Downey, Cameron S. McAlpine, Henrike Janssen
Publikováno v:
Nature. 595(7869)
Communication within the glial cell ecosystem is essential for neuronal and brain health1–3. The influence of glial cells on the accumulation and clearance of β-amyloid (Aβ) and neurofibrillary tau in the brains of individuals with Alzheimer’s
Autor:
Djuna, von Maydell, Mehdi, Jorfi
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2258
Self-assembling brain spheroids derived from human stem cells closely emulate the tangled connectivity of the human brain, recapitulate aspects of organized tissue structure, and are relatively easy to manipulate compared to other existing three-dime