Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Mehdi Fakhfakh"'
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Akademický článek
Design and Synthesis of Novel N-Benzylidene Derivatives of 3-Amino-4-imino-3,5-dihydro-4H-chromeno[2,3-d]pyrimidine under Microwave, In Silico ADME Predictions, In Vitro Antitumoral Activities and In Vivo Toxicity
Autor: Sirine Karoui, Marwa Dhiabi, Mehdi Fakhfakh, Souhir Abid, Emmanuelle Limanton, Rémy Le Guével, Thierry D. Charlier, Anthony Mainguy, Olivier Mignen, Ludovic Paquin, Houcine Ammar, Jean-Pierre Bazureau
Publikováno v: Pharmaceuticals, Vol 17, Iss 4, p 458 (2024)
The synthesis of a series of new N-benzylidene derivatives of 3-amino-4-imino-3,5-dihydro-4H-chromeno[2,3-d]pyrimidine 10(a-l) bearing two points of molecular diversity is reported. These new compounds were synthesized in five steps including two ste
Externí odkaz: https://doaj.org/article/43610251a2dd4137a78b0ed0fe719ef6
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3
Practical approach to N-benzyl derivatives of 2-amino-8-methoxy-4H-chromene-3-carbonitrile by reductive amination: Exploration of their effects against protein kinases and in silico ADME profiling
Autor: Marwa Dhiabi, Ali Bouattour, Mehdi Fakhfakh, Souhir Abid, Ludovic Paquin, Thomas Robert, Stephane Bach, Jean-Pierre Bazureau, Houcine Ammar
Publikováno v: Journal of Molecular Structure
Journal of Molecular Structure, 2023, 1274 (Part 1), pp.134319. ⟨10.1016/j.molstruc.2022.134319⟩
International audience; The synthesis of 2-benzylamino-8-methoxy-4 H-chromene-3-carbonitriles 7(a-e) has been realized in four steps, via reductive amination from the 2-amino-8-methoxy-4 H-chromene-3-carbonitrile 4 as key intermediate platform with p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599b51e5433298885ec52b5100046ed5
https://doi.org/10.1016/j.molstruc.2022.134319
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4
An Efficient and Concise Synthesis of N-3-Substituted 9-Methoxy-4H-[1]-benzopyrano[2,3-d]pyrimidine-4(5H)-imines and Form­amidine Derivatives from Methyl N-(3-Cyano-8-methoxy-4H-[1]-benzopyran-2-yl)methanimidate
Autor: Houcine Ammar, Jean Pierre Bazureau, Mehdi Fakhfakh, Ludovic Paquin, Ali Bouattour, Souhir Abid
Publikováno v: Synthesis: Journal of Synthetic Organic Chemistry
Synthesis: Journal of Synthetic Organic Chemistry, 2017, 49 (16), pp.3768--3774. ⟨10.1055/s-0036-1588825⟩
SYNTHESIS
SYNTHESIS, Georg Thieme Verlag, 2017, 49 (16), pp.3768--3774. ⟨10.1055/s-0036-1588825⟩
International audience; A four-step microwave-assisted reaction of N-3-susbstituted 4 H -[1]-benzopyrano[2,3- d ]pyrimidine-4(5 H)-imines and formamidine derivatives was successfully developed from primary amines, cyclic secondary amines, and methyl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f119f6270c39a07db0a8e403bc1cb49
https://doi.org/10.1055/s-0036-1588825
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5
Reactivity under Microwave Irradiation of 2-Amino 4H-chromene-3-carbonitrile as Tool for the Construction of Potential Bioactive Derivatives
Autor: Stéphane Bach, Rémy Le Guével, Sandrine Ruchaud, Bazureau Jean Pierre, Houcine Ammar, Mehdi Fakhfakh, Ali Bouattour, Souhir Abid, Ludovic Paquin, Anne Corlu
Publikováno v: Proceedings of 3rd International Electronic Conference on Medicinal Chemistry.
4H-Chromenes (or 4H-benzopyranes) and their derivatives are components of many naturally occurring products, which have also been submitted to structural modifications to increase molecular diversity for potential medicinal properties. In this contex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f4a6c5bf800e148bad5edde2f6a3f5b
https://doi.org/10.3390/ecmc-3-04709
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6
Microwave-assisted practical synthesis of 4-imino-3-phenyl-3,4-dihydro-1H-chromeno[2,3-d]pyrimidine-2(5H)-thione derivatives and exploration of their biological activities
Autor: Souhir Abid, Mehdi Fakhfakh, Jean Pierre Bazureau, Ludovic Paquin, Ali Bouattour, Stéphane Bach, Anne Corlu, Sandrine Ruchaud, R. Le Guevel, Houcine Ammar
Publikováno v: ARKIVOC-Online Journal of Organic Chemistry
ARKIVOC-Online Journal of Organic Chemistry, 2017, 2017 (4), pp.291--302. ⟨10.24820/ark.5550190.p010.040⟩
ARKIVOC, Vol 2017, Iss 4, Pp 291-302 (2017)
ARKIVOC-Online Journal of Organic Chemistry, Arkat USA Inc, 2017, 2017 (4), pp.291--302. ⟨10.24820/ark.5550190.p010.040⟩
International audience; The synthesis of a series of new 4-imino-3,4-dihydro-1H-chromeno[2,3-d]pyrimidine-2(5H)-thiones 6(a-f) without substituent in C-5 position using microwave dielectric heating is reported. These new compounds were obtained in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d116e264811151924581b6dee5987ff
https://univ-rennes.hal.science/hal-01581215
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7
The synthesis and optical properties of novel fluorescent iminocoumarins and bis-iminocoumarins: Investigations in the series of urea derivatives
Autor: Suzanne Fery-Forgues, Mehdi Fakhfakh, Rachid El Gharbi, Hamida Turki
Publikováno v: Dyes and Pigments. 84:108-113
The condensation of 3-cyano-7-diethylamino-iminocoumarin with various isocyanates and diisocyanates as C-electrophiles gave a new series of N-substituted iminocoumarins and bis-iminocoumarins. The ten compounds obtained were characterized using IR, 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::144b18182d451d4bf1239cbd14c54b87
https://doi.org/10.1016/j.dyepig.2009.07.003
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8
Preparation and optical properties of new fluorescent iminocoumarins: Study of N-acyl-derivatives
Autor: Souhir Abid, Mehdi Fakhfakh, Suzanne Fery-Forgues, Rachid El Gharbi, Hamida Turki
Publikováno v: Journal of Photochemistry and Photobiology A: Chemistry. 185:13-18
Six new iminocoumarin dyes, bearing a cyano group at the 3-position and a diethylamino group at the 7-position, were synthesized. These compounds differ by the nature of the acyl substituent borne by the imino group. They were studied in CH 2 Cl 2 an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b801c0b8af6dc70a9d55e7c4e4a4f2e
https://doi.org/10.1016/j.jphotochem.2006.04.036
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9
Synthesis of Newbis-Iminocoumarins by Schmidt Reaction Catalyzed by Ion-Exchange Resins
Autor: Yves Le Bigot, Mehdi Fakhfakh, Rachid El Gharbi, Houcine Ammar
Publikováno v: Synthetic Communications. 33:1821-1828
A new synthetic route to bis-iminocoumarins is proposed which involves the synthesis of iminocoumarins from reaction of 2-hydroxybenzaldehydes with arylacetonitriles and their coupling with aromatic diamines. Ion-exchange resins were used as catalyst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4457dd2210e270e2643a22ed575a42c1
https://doi.org/10.1081/scc-120020190
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10
Synthesis of New Bis-iminocoumarins by Schmidt Reaction Catalyzed by Ion-Exchange Resins
Autor: Rachid El Gharbi, Yves Le Bigot, Houcine Ammar, Mehdi Fakhfakh
Publikováno v: ChemInform. 34
A new synthetic route to bis-iminocoumarins is proposed which involves the synthesis of iminocoumarins from reaction of 2-hydroxybenzaldehydes with arylacetonitriles and their coupling with aromatic diamines. Ion-exchange resins were used as catalyst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::815113a484d5815577e79b5382c86a36
https://doi.org/10.1002/chin.200337113
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