Leishmania major large RAB GTPase is highly immunogenic in individuals immune to cutaneous and visceral leishmaniasis

Autor: Rym Chamakh-Ayari, Mehdi Chenik, Ahmed Sahbi Chakroun, Narges Bahi-Jaber, Karim Aoun, Amel Meddeb-Garnaoui

Publikováno v: Parasites & Vectors, Vol 10, Iss 1, Pp 1-11 (2017)

Abstract Background We previously identified a Leishmania (L.) major large RAB GTPase (LmlRAB), a new atypical RAB GTPase protein. It is highly conserved in Leishmania species while displaying low level of homology with mammalian homologues. Leishman

Externí odkaz: https://doaj.org/article/a4bbec53984c44e3833803327d55c385

Immunomodulatory Effects of Four Leishmania infantum Potentially Excreted/Secreted Proteins on Human Dendritic Cells Differentiation and Maturation.

Autor: Wafa Markikou-Ouni, Sima Drini, Narges Bahi-Jaber, Mehdi Chenik, Amel Meddeb-Garnaoui

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143063 (2015)

Leishmania parasites and some molecules they secrete are known to modulate innate immune responses through effects on dendritic cells (DCs) and macrophages. Here, we characterized four Leishmania infantum potentially excreted/secreted recombinant pro

Externí odkaz: https://doaj.org/article/f8065f009d6d4b63894500a5f64ba8bb

Prediction of T Cell Epitopes from Leishmania major Potentially Excreted/Secreted Proteins Inducing Granzyme B Production

Autor: Nabil Belhadj Hmida, Yousr Gorgi, Sami Gritli, Ikbel Naouar, Melika Ben Ahmed, Afif Ben Salah, Narges Bahi-Jaber, Rafika Bardi, Hechmi Louzir, Mehdi Chenik, Thouraya Boussoffara

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2016, 11 (1), pp.e0147076. ⟨10.1371/journal.pone.0147076⟩
PLoS ONE, Vol 11, Iss 1, p e0147076 (2016)

Leishmania-specific cytotoxic T cell response is part of the acquired immune response developed against the parasite and contributes to resistance to reinfection. Herein, we have used an immune-informatic approach for the identification, among Leishm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4484e6b3e2bb44c449e6e4c3939de3
https://hal.archives-ouvertes.fr/hal-01356501

Comparative Evaluation of Two Vaccine Candidates against Experimental Leishmaniasis Due toLeishmania majorInfection in Four Inbred Mouse Strains

Autor: Fouad Benhnini, Pierre André Cazenave, Koussay Dellagi, Hechmi Louzir, Dhafer Laouini, Mehdi Chenik

Publikováno v: Clinical and Vaccine Immunology
Clinical and Vaccine Immunology, 2009, 16 (11), pp.1529-37. ⟨10.1128/CVI.00153-09⟩
Clinical and Vaccine Immunology, American Society for Microbiology, 2009, 16 (11), pp.1529-37. ⟨10.1128/CVI.00153-09⟩

ABSATRCTExperimental leishmaniasis in BALB/c and C57BL/6 mice are the most investigated murine models that were used for the preclinical evaluation ofLeishmaniavaccine candidates. We have previously described two new inbred mouse strains named PWK an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1f5db3ed0386d290be520e70aa1dc9
https://doi.org/10.1128/cvi.00153-09

Gene expression analysis of wild Leishmania major isolates: identification of genes preferentially expressed in amastigotes

Autor: Meriem Ouakad, Mehdi Chenik, Hechmi Louzir, Koussay Dellagi, Yosser Ben Achour-Chenik

Publikováno v: Parasitology Research. 100:255-264

Trying to identify virulence genes of wild Leishmania (L.) major parasites, the species responsible for zoonotic cutaneous leishmaniasis, we compared, using differential display technique, gene expression in two L. major isolates obtained from human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b336295ef9dea8003397698a65ed2a66
https://doi.org/10.1007/s00436-006-0277-x