Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Mehdi Arbabi-Ghahroudi"'
Autor:
Mehdi Arbabi-Ghahroudi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5009 (2022)
Since the discovery of camelid heavy-chain antibodies in 1993, there has been tremendous excitement for these antibody domains (VHHs/sdAbs/nanobodies) as research tools, diagnostics, and therapeutics. Commercially, several patents were granted to pio
Externí odkaz:
https://doaj.org/article/77ad8daf940a4fb9954c4292dcab04a3
Autor:
Mehdi Arbabi-Ghahroudi
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Tremendous effort has been expended over the past two and a half decades to understand many aspects of camelid heavy chain antibodies, from their biology, evolution, and immunogenetics to their potential applications in various fields of research and
Externí odkaz:
https://doaj.org/article/aa143800776a462cbcf4f98f049dc22f
Autor:
Marzia Martina, Umberto Banderali, Alvaro Yogi, Mehdi Arbabi Ghahroudi, Hong Liu, Traian Sulea, Yves Durocher, Greg Hussack, Henk van Faassen, Balu Chakravarty, Qing Yan Liu, Umar Iqbal, Binbing Ling, Etienne Lessard, Joey Sheff, Anna Robotham, Debbie Callaghan, Maria Moreno, Tanya Comas, Dao Ly, Danica Stanimirovic
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Genetic studies have identified the voltage‐gated sodium channel 1.7 (Nav1.7) as pain target. Due to the ineffectiveness of small molecules and monoclonal antibodies as therapeutics for pain, single‐domain antibodies (VHHs) are developed
Externí odkaz:
https://doaj.org/article/25473da9710e4c68b7eed6b4056350ba
Autor:
Kevin A Henry, Traian Sulea, Henk van Faassen, Greg Hussack, Enrico O Purisima, C Roger MacKenzie, Mehdi Arbabi-Ghahroudi
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163113 (2016)
Staphylococcal protein A (SpA) and streptococcal protein G (SpG) affinity chromatography are the gold standards for purifying monoclonal antibodies (mAbs) in therapeutic applications. However, camelid VHH single-domain Abs (sdAbs or VHHs) are not bou
Externí odkaz:
https://doaj.org/article/2d1ae8285664432b857d78cf57c413ed
Autor:
Gabrielle Richard, Ashley J Meyers, Michael D McLean, Mehdi Arbabi-Ghahroudi, Roger MacKenzie, J Christopher Hall
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69495 (2013)
Small recombinant antibody fragments (e.g. scFvs and VHHs), which are highly tissue permeable, are being investigated for antivenom production as conventional antivenoms consisting of IgG or F(ab')2 antibody fragments do not effectively neutralize ve
Externí odkaz:
https://doaj.org/article/8cb147b012534ae4925d5a353a4eabbd
Autor:
Toya Nath Baral, Shi-Yu Chao, Shenghua Li, Jamshid Tanha, Mehdi Arbabi-Ghahroudi, Jianbing Zhang, Shuying Wang
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30149 (2012)
Single-domain antibodies (sdAbs) derived from human V(H) are considered to be less soluble and prone to aggregate which makes it difficult to determine the crystal structures. In this study, we isolated and characterized two anti-human epidermal grow
Externí odkaz:
https://doaj.org/article/37bdc78d6f0c4c1da1d54425b52176c8
Autor:
Frédéric, Trempe, Martin A, Rossotti, Tahir, Maqbool, C Roger, MacKenzie, Mehdi, Arbabi-Ghahroudi
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2446
Genetic immunization is a simple, cost-effective, and powerful tool for inducing innate and adaptive immune responses to combat infectious diseases and difficult-to-treat illnesses. DNA immunization is increasingly used in the generation of monoclona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5de5c553b7d4367a5d578f7220b58ad
https://pubmed.ncbi.nlm.nih.gov/35157268
https://pubmed.ncbi.nlm.nih.gov/35157268
Autor:
Frédéric Trempe, Martin A. Rossotti, Tahir Maqbool, C. Roger MacKenzie, Mehdi Arbabi-Ghahroudi
Publikováno v:
Methods in Molecular Biology ISBN: 9781071620748
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9ad245bc8b63f464f4aa647c27fa4c
https://doi.org/10.1007/978-1-0716-2075-5_3
https://doi.org/10.1007/978-1-0716-2075-5_3
Autor:
Greg Hussack, Cunle Wu, Thanh-Dung Nguyen, C. Roger MacKenzie, Mehdi Arbabi-Ghahroudi, Kevin A. Henry, Alma Robert, Toya Nath Baral, Yves Durocher, Maria L. Jaramillo, Shalini Raphael
Overexpression of Axl, a TAM-family receptor tyrosine kinase, plays key roles in the formation, growth, and spread of tumors as well as resistance to targeted therapies and chemotherapies. We identified novel llama VHHs against human Axl using multip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2591cdc16552658d421ed90aaff11f9
https://doi.org/10.1016/j.bbrc.2021.05.030
https://doi.org/10.1016/j.bbrc.2021.05.030
Autor:
Kevin A. Henry, Jyothi Kumaran, Traian Sulea, Mehdi Arbabi-Ghahroudi, Michel Gilbert, C. Roger MacKenzie, Greg Hussack
Publikováno v:
Journal of Molecular Recognition. 32
Single-domain antibodies (sdAbs), the variable domains of camelid heavy chain-only antibodies, are generally thought to poorly recognize nonproteinaceous small molecules and carbohydrates in comparison with conventional antibodies. However, the struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f47dc4842f6b690304db2ebd738211
https://doi.org/10.1002/jmr.2805
https://doi.org/10.1002/jmr.2805