In Pursuit of Stability Enhancement of a Prostate Cancer Targeting Antibody Derived from a Transgenic Animal Platform

Autor: Sathyadevi Venkataramani, Rajkumar Ganesan, Sanjaya Singh, Robin Ernst, Mehabaw G. Derebe, Steven Jacobs, Robert Wright, Jessica Kopenhaver

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)

Accelerated timelines necessitate the discovery of fully human antibodies as biotherapeutics using transgenic animals with a notion that such mAbs bypass humanization. A transgenic animal derived mAb (PCa75) targeted against a prostate cancer antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1711320f2448796fe9892a57ed222fad
https://doi.org/10.1038/s41598-020-66636-z

Rapid Purification of Human Bispecific Antibodies via Selective Modulation of Protein A Binding

Autor: Dennis R. Goulet, Rose Decker, Jose Pardinas, Susan H. Tam, Eva Emmell, Mark L. Chiu, Songmao Zheng, Mehabaw G. Derebe, Catherine N. Leettola, Adam Zwolak

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports

Methods to rapidly generate high quality bispecific antibodies (BsAb) having normal half-lives are critical for therapeutic programs. Here, we identify 3 mutations (T307P, L309Q, and Q311R or “TLQ”) in the Fc region of human IgG1 which disrupt in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0a800975376ddc9448fee52cea3518
http://link.springer.com/article/10.1038/s41598-017-15748-0

FcγRII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibody

Autor: Mehabaw G. Derebe, Di Zhang, Brian Whitaker, Mark L. Chiu

Publikováno v: mAbs

Immunostimulatory antibodies against the tumor necrosis factor receptors (TNFR) are emerging as promising cancer immunotherapies. The agonism activity of such antibodies depends on crosslinking to Fc gamma RIIB receptor (FcγRIIB) to enable the antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc904529e6fdf01d49224810583c7b3
https://pubmed.ncbi.nlm.nih.gov/29359992

Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection

Autor: Lora V. Hooper, Shipra Vaishnava, Sureka Gattu, John B. MacMillan, Gretchen E. Diehl, Kelly A. Ruhn, Noelle S. Williams, Clare M Zlatkov, Mehabaw G. Derebe

Publikováno v: eLife, Vol 3 (2014)

Retinol plays a vital role in the immune response to infection, yet proteins that mediate retinol transport during infection have not been identified. Serum amyloid A (SAA) proteins are strongly induced in the liver by systemic infection and in the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5b53535102ee0da1a89dadadcc6ebd
https://pubmed.ncbi.nlm.nih.gov/25443493

Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Autor: Sohini Mukherjee, Josep Rizo, Darcy Rollins, Daniel C. Propheter, Hui Zheng, Carrie L. Partch, Qiu-Xing Jiang, Mehabaw G. Derebe, Michael Grabe, Lora V. Hooper, Keith M. Callenberg

Publikováno v: Nature, vol 505, iss 7481
Nature
Mukherjee, S; Zheng, H; Derebe, MG; Callenberg, KM; Partch, CL; Rollins, D; et al.(2014). Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature, 505(7481), 103-107. doi: 10.1038/nature12729. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4gs221w5

Human body-surface epithelia coexist in close association with complex bacterial communities and are protected by a variety of antibacterial proteins. C-type lectins of the RegIII family are bactericidal proteins that limit direct contact between bac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfc248029e6b8337802e6b97a30550b
https://escholarship.org/uc/item/4gs221w5