Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Megumi Tasaka-Fujita"'
Autor:
Takahiro Masaki, Asako Murayama, Koji Ishii, Akihide Ryo, Hussein H. Aly, Sayuri Nitta, Megumi Tasaka-Fujita, Masaaki Shiina, Takanobu Kato, Norie Yamada, Ryuichi Sugiyama, Takaji Wakita
Publikováno v:
Oncotarget
// Ryuichi Sugiyama 1 , Asako Murayama 1 , Sayuri Nitta 1, 2, 3 , Norie Yamada 1 , Megumi Tasaka-Fujita 1, 2 , Takahiro Masaki 1, 6 , Hussein Hassan Aly 1 , Masaaki Shiina 1, 4 , Akihide Ryo 5 , Koji Ishii 1 , Takaji Wakita 1 and Takanobu Kato 1 1 De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220d90c2b576b54da2e6aefa106188cf
https://doi.org/10.18632/oncotarget.23562
https://doi.org/10.18632/oncotarget.23562
Autor:
Megumi Tasaka-Fujita, Yasuhiro Itsui, Yasuhiro Asahina, Takako Watanabe, Miyako Murakawa, Sei Kakinuma, Mina Nakagawa, Fumio Goto, Fukiko Kawai-Kitahata, Shun Kaneko, Mamoru Watanabe, Miki Taniguchi, Hiroko Nagata, Satoshi Ootani, Yuki Nishimura-Sakurai, Seishin Azuma
Publikováno v:
Hepatology Research. 46:312-319
Aim For intermediate hepatocellular carcinoma (HCC), transcatheter arterial chemoembolization (TACE) therapy is recommended in the guidelines as a monotherapy, although TACE is a non-curative therapy. The aims of the present study were to evaluate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daab16eb551acdf3ae69be8ad6980937
https://doi.org/10.1111/hepr.12566
https://doi.org/10.1111/hepr.12566
Autor:
Mamoru Watanabe, Megumi Tasaka-Fujita, Kako Mishima, Naoya Sakamoto, Miyako Murakawa, Yasuhiro Asahina, Mina Nakagawa, Takashi Fujita, Sayuri Nitta, Sei Kakinuma, Mitsutoshi Yoneyama, Yuki Nishimura-Sakurai, Seishin Azuma, Kei Kiyohashi, Akiko Kusano-Kitazume
Publikováno v:
Hepatology. 57:46-58
Hepatitis C virus (HCV) infection blocks cellular interferon (IFN)-mediated antiviral signaling through cleavage of Cardif by HCV-NS3/4A serine protease. Like NS3/4A, NS4B protein strongly blocks IFN-β production signaling mediated by retinoic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852529e58b7eaa0c7b9cdaad8a34c217
https://doi.org/10.1002/hep.26017
https://doi.org/10.1002/hep.26017
Autor:
Mamoru Watanabe, Goki Suda, Seishin Azuma, Takako Watanabe, Kazuaki Chayama, Megumi Tasaka-Fujita, Yasuhiro Itsui, Sayuri Nitta, Mina Nakagawa, Kiichiro Tsuchiya, Michio Imamura, Kei Kiyohashi, Naoya Sakamoto, Yusuke Funaoka, Sei Kakinuma, Nobuhiko Hiraga
Publikováno v:
Virology. 407(1):80-90
Mechanisms of difference in interferon sensitivity between hepatitis C virus (HCV) strains have yet to be clarified. Here, we constructed an infectious genotype2b clone and analyzed differences in interferon-alpha sensitivity between HCV-2b and 2a-JF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce52a35de04960637849f232dc00f15a
Autor:
Mina Nakagawa, Takako Watanabe, Satoshi Nagaie, Hiroshi Tanaka, Yuko Onuki-Karakama, Yuki Nishimura-Sakurai, Yusuke Funaoka, Nobuyuki Enomoto, Machi Yamamoto, Mamoru Watanabe, Megumi Tasaka-Fujita, Kako Mishima, Seishin Azuma, Yasuhiro Itsui, Yuko Sekine-Osajima, Kaoru Mogushi, Kiichiro Tsuchiya, Naoya Sakamoto, Sei Kakinuma, Goki Suda, Mayumi Ueyama
Publikováno v:
Journal of Gastroenterology. 45:523-536
Hepatitis C virus (HCV) replication is affected by several host factors. Here, we screened host genes and molecular pathways that are involved in HCV replication by comprehensive analyses using two genotypes of HCV replicon-expressing cells, their cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1eb2cf4d0092dcc55dabbdb203969c
https://doi.org/10.1007/s00535-009-0162-3
https://doi.org/10.1007/s00535-009-0162-3
Autor:
Megumi Tasaka-Fujita, Nao Sugiyama, Wonseok Kang, Takahiro Masaki, Asako Murayama, Norie Yamada, Ryuichi Sugiyama, Senko Tsukuda, Koichi Watashi, Yasuhiro Asahina, Naoya Sakamoto, Takaji Wakita, Eui-Cheol Shin, Takanobu Kato
Publikováno v:
Scientific Reports. 5
Amino acid (aa) polymorphisms in the hepatitis C virus (HCV) genotype 1b core protein have been reported to be a potent predictor for poor response to interferon (IFN)-based therapy and a risk factor for hepatocarcinogenesis. We investigated the effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a54ed07edd895791bf5de34c70eb25d8
https://doi.org/10.1038/srep17208
https://doi.org/10.1038/srep17208
Autor:
Miyako Murakawa, Mamoru Watanabe, Megumi Tasaka-Fujita, Takako Watanabe, Shintaro Yagi, Fukiko Kawai-Kitahata, Seishin Azuma, Yasuhiro Itsui, Kenichi Mori, Satoshi Otani, Fumio Goto, Shun Kaneko, Mina Nakagawa, Sei Kakinuma, Miki Taniguchi, Hiroko Nagata, Sayuri Nitta, Yasuhiro Asahina, Yuki Nishimura-Sakurai
Publikováno v:
Journal of Clinical and Translational Hepatology
Background and Aims: The hepatitis C virus (HCV) genotype 1b is known to exhibit treatment resistance with respect to interferon (IFN) therapy. Substitution of amino acids 70 and 91 in the core region of the 1b genotype is a significant predictor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1667ec28738e46ff67bbe6e4e52958b0
https://pubmed.ncbi.nlm.nih.gov/27047766
https://pubmed.ncbi.nlm.nih.gov/27047766
Autor:
Mamoru Watanabe, Shinji Tanaka, Takako Watanabe, Yasuhiro Itsui, Satoshi Otani, Minoru Tanabe, Shinya Maekawa, Shinichi Takano, Fumio Goto, Sei Kakinuma, Nobuyuki Enomoto, Miki Taniguchi, Shun Kaneko, Yasuhiro Asahina, Minoru Sakamoto, Hiroko Nagata, Sayuri Nitta, Mitsuharu Fukasawa, Miyako Murakawa, Megumi Tasaka-Fujita, Seishin Azuma, Mina Nakagawa, Yuki Nishimura-Sakurai, Fukiko Kawai-Kitahata
Publikováno v:
Journal of gastroenterology. 51(5)
Genetic alterations in specific genes are critical events in carcinogenesis and hepatocellular carcinoma (HCC) progression. However, the genetic alterations responsible for HCC development, progression, and survival are unclear. We investigated the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a1231d0a5e4581e8d1e0a25a1cd0a9
https://pubmed.ncbi.nlm.nih.gov/26553052
https://pubmed.ncbi.nlm.nih.gov/26553052
Autor:
Yasuhiro Asahina, Won-Seok Kang, Senko Tsukuda, Asako Murayama, Takanobu Kato, Megumi Tasaka-Fujita, Takahiro Masaki, Norie Yamada, Naoya Sakamoto, Ryuichi Sugiyama, Takaji Wakita, Koichi Watashi, Eui-Cheol Shin, Nao Sugiyama
Publikováno v:
Scientific Reports
Amino acid (aa) polymorphisms in the hepatitis C virus (HCV) genotype 1b core protein have been reported to be a potent predictor for poor response to interferon (IFN)-based therapy and a risk factor for hepatocarcinogenesis. We investigated the effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60dfb6e14eb9668730fe774bd9a827d
https://pubmed.ncbi.nlm.nih.gov/26670698
https://pubmed.ncbi.nlm.nih.gov/26670698
Autor:
Seishin, Azuma, Yasuhiro, Asahina, Yuki, Nishimura-Sakurai, Sei, Kakinuma, Shun, Kaneko, Hiroko, Nagata, Fumio, Goto, Satoshi, Ootani, Fukiko, Kawai-Kitahata, Miki, Taniguchi, Miyako, Murakawa, Takako, Watanabe, Megumi, Tasaka-Fujita, Yasuhiro, Itsui, Mina, Nakagawa, Mamoru, Watanabe
Publikováno v:
Hepatology research : the official journal of the Japan Society of Hepatology. 46(4)
For intermediate hepatocellular carcinoma (HCC), transcatheter arterial chemoembolization (TACE) therapy is recommended in the guidelines as a monotherapy, although TACE is a non-curative therapy. The aims of the present study were to evaluate the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b071b8536dab1a4b27100245db7af8c6
https://pubmed.ncbi.nlm.nih.gov/26224167
https://pubmed.ncbi.nlm.nih.gov/26224167