Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Megumi Ohkubo"'
Autor:
Daisuke Hashizume, Megumi Ohkubo, Go Hirai, Mikiko Sodeoka, Hiroyuki Koshino, Keiji Maruoka, Masaki Morita
Publikováno v:
Organic Letters. 14:3434-3437
The characteristic DEFGH-ring system of type B physalins has been synthesized by means of a one-pot procedure incorporating domino-type ring transformations. Unexpectedly, we found that introduction of an α-hydroxyester functionality at C17 in ring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffbe0d3518495e575f7b584f756ff77
https://doi.org/10.1021/ol301394b
https://doi.org/10.1021/ol301394b
Autor:
Yosuke Ogoshi, Go Hirai, Mikiko Sodeoka, Tadashi Shimizu, Yuki Tamura, Toru Watanabe, Megumi Ohkubo
Publikováno v:
Tetrahedron Letters. 50:3609-3612
Efficient enantio-selective synthesis of conformationally constrained diacylglycerol analogues, 7-substituted isobenzofuranone derivatives, originally developed by us as PKCα ligands, was achieved by asymmetric dihydroxylation and γ-lactone formati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05788909d9dd43463d0751852fd057a7
https://doi.org/10.1016/j.tetlet.2009.03.069
https://doi.org/10.1016/j.tetlet.2009.03.069
Publikováno v:
Angewandte Chemie International Edition. 48:3862-3866
Let the dominos fall: Synthesis of the complex DFGH ring system of the title compounds has been accomplished. The approach features simple treatment of the key intermediate with a Brønsted base to afford the tetracyclic cage-shaped target in one pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4149d61b6556280b15949beaef14de4b
https://doi.org/10.1002/anie.200900634
https://doi.org/10.1002/anie.200900634
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(12)
Novel types of PKCα activators based on isobenzofuranone bearing a myo-inositol moiety were designed and synthesized. The derivatives with bulky substituents on the myo-inositol moiety significantly activated PKCα, but their binding sites were not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033727b327863de83ec1735474cbd5d2
https://pubmed.ncbi.nlm.nih.gov/21596562
https://pubmed.ncbi.nlm.nih.gov/21596562
Publikováno v:
ChemMedChem. 2(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32be5c03073853cc9eac9e50ab6ef15b
https://pubmed.ncbi.nlm.nih.gov/17492704
https://pubmed.ncbi.nlm.nih.gov/17492704