Výsledky vyhledávání - "Megumi Kumura"

Synthesis and structure–activity relationships of novel lincomycin derivatives. Part 1. Newly generated antibacterial activities against Gram-positive bacteria with erm gene by C-7 modification

Autor: Ko Kumura, Kazutaka Ueda, Eijiro Umemura, Hideki Fushimi, Yoshinari Wakiyama, Megumi Kumura, Satomi Masaki, Keiichi Ajito

Publikováno v: The Journal of Antibiotics. 69:368-380

We synthesized 7(S)-7-deoxy-7-arylthiolincomycin derivatives possessing a heterocyclic ring at the C-7 position via sulfur atom by either Mitsunobu reaction of 2,3,4-tris-O-(trimethylsiliyl)lincomycin or SN2 reaction of 7-O-methanesulfonyl-2,3,4-tri-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc2ac900c1d7ff2aade6371fe8fef76
https://doi.org/10.1038/ja.2015.119

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Synthesis and antibacterial activity of novel lincomycin derivatives. II. Exploring (7S)-7-(5-aryl-1,3,4-thiadiazol-2-yl-thio)-7-deoxylincomycin derivatives

Autor: Takuji Yoshida, Yoshinari Wakiyama, Takashi Watanabe, Ko Kumura, Kazutaka Ueda, Keiichi Ajito, Eijiro Umemura, Megumi Kumura

Publikováno v: The Journal of antibiotics. 70(5)

The synthesis and antibacterial activity of (7S)-7-(5-aryl-1,3,4-thiadiazol-2-yl-thio)-7-deoxylincomycin derivatives are described. These derivatives were mainly prepared by the Mitsunobu reaction of 2,3,4-tris-O-(trimethylsilyl)lincomycin and the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138e0e36e21043d4993d7ba1c0f07e78
https://pubmed.ncbi.nlm.nih.gov/27924113

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