Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Megumi Honjo"'
Autor:
Kaho Akiyama, Hitomi Saito, Shuichiro Aoki, Shiroaki Shirato, Aiko Iwase, Koichiro Sugimoto, Rei Sakata, Megumi Honjo, Makoto Aihara
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract This study aimed to evaluate the effect of magnification error and axial length (AL) on circumpapillary capillary density (cpCD) and circumpapillary retinal nerve fiber layer thickness (cpRNFLT) in healthy eyes. Seventy-two healthy eyes of 7
Externí odkaz:
https://doaj.org/article/6f55ade33ec04f2e9b14e0c24d6f33a7
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Ripasudil–brimonidine fixed-dose combination (K-232) simultaneously targets three different intraocular pressure (IOP) lowering mechanisms, increasing trabecular meshwork outflow and uveoscleral outflow, and reducing aqueous humor producti
Externí odkaz:
https://doaj.org/article/dd29460ebfc54370baf6fc3457027aee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Better agents are needed to improve glaucoma filtration surgery outcomes compared to current ones. The purpose of this study is to determine whether mitogen-activated protein kinase kinase (MEK) inhibitors can effectively arrest the cell cyc
Externí odkaz:
https://doaj.org/article/01d95dd8f83d43bd8fa1a316f98236fa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The intraocular pressure (IOP)-lowering mechanisms of micropulse laser trabeculoplasty (MLT) remain unclear. The present study was performed to investigate the mechanism of action of MLT, and to determine whether the pigmentation intensity o
Externí odkaz:
https://doaj.org/article/ca00fbaa8e184d17b05385a3301d5367
Autor:
Kaho Akiyama, Hitomi Saito, Shiroaki Shirato, Aiko Iwase, Koichiro Sugimoto, Takashi Fujishiro, Hiroshi Murata, Rei Sakata, Megumi Honjo, Makoto Aihara
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract This study aimed to evaluate the diagnostic ability and sectoral structure function relationship of circumpapillary vessel density (cpVD) and macular vessel density (mVD) with optical coherence tomography angiography (OCTA) in early glaucoma
Externí odkaz:
https://doaj.org/article/4e6bb525381f4c2b88c29b653511fca8
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract This study investigated the effects of omidenepag (OMD), a novel selective EP2 receptor agonist, on human trabecular meshwork (HTM) cells, monkey Schlemm’s canal endothelial (SCE) cells, and porcine ciliary muscle (CM) to clarify the mecha
Externí odkaz:
https://doaj.org/article/dccdf48355c74765b1d9b965b6374adf
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract We examined the effects of mTOR inhibitors on the fibrotic response induced by transforming growth factor-beta2 (TGF-β2) in cultured human trabecular meshwork (hTM) cells. TGF-β2-induced expression of fibronectin, collagen type I, alpha 1
Externí odkaz:
https://doaj.org/article/0d72df1cb3494545b07a52c213b76667
Autor:
Nozomi Igarashi, Megumi Honjo, Reiko Yamagishi, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Toshikatsu Kaburaki, Makoto Aihara
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-19 (2021)
Abstract Background Elevated transforming growth factor (TGF)-β2 in aqueous humor (AH) has been suggested to contribute to trabecular meshwork (TM) fibrosis and intraocular pressure (IOP) regulation in primary open-angle glaucoma (POAG), but TGF-β2
Externí odkaz:
https://doaj.org/article/f3b98da63d58464db84a7f1377e8342a
Autor:
Takatoshi Uchida, Shota Shimizu, Reiko Yamagishi, Suzumi M. Tokuoka, Yoshihiro Kita, Megumi Honjo, Makoto Aihara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The trabecular meshwork (TM) constitutes the main pathway for aqueous humor drainage and is exposed to complex intraocular pressure fluctuations. The mechanism of homeostasis in which TM senses changes in intraocular pressure and leads to no
Externí odkaz:
https://doaj.org/article/3a790bb7932047738f10802992a9fe8f
Autor:
Nozomi Igarashi, Megumi Honjo, Ryo Asaoka, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Kazunori Miyata, Toshikatsu Kaburaki, Makoto Aihara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The purpose of this study is to examine if aqueous autotaxin (ATX) and TGF-β levels could be used for differentiating glaucoma subtypes. This prospective observational study was performed using aqueous humor samples obtained from 281 consec
Externí odkaz:
https://doaj.org/article/e16a119e540e408f8915e1f16a700ca4