Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Megumi Hato"'
Quantifying Protein-Specific N-Glycome Profiles by Focused Protein and Immunoprecipitation Glycomics
Autor:
Goki Suda, Takuya Sho, Tomoyo Yoshinaga, Megumi Hato, Koji Ogawa, Yasuro Shinohara, Kenichi Higashino, Takashi Kobayashi, Kenichi Morikawa, Yoshito Numata, Jun-ichi Furukawa, Masato Nakai, Naoya Sakamoto, Hisatoshi Hanamatsu
Publikováno v:
Journal of proteome research. 18(8):3133-3141
Serum N-glycans have been reported to be potential diagnostic and therapeutic biomarkers for many diseases and conditions, such as inflammation, fibrosis, and cancer progression. We previously described the focused protein glycomic analysis (FPG) fro
Autor:
Noriyasu Kondo, Mana Ito, Shuhei Shigaki, Megumi Hato, Ryo Yoshimoto, Takayuki Okuno, Kyohei Hayashi, Naoki Omori, Ayumi Nagasawa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 33:127722
Long-chain acyl-CoA synthetase-1 (ACSL1), an enzyme that catalyzes the synthesis of long-chain acyl-CoA from the corresponding fatty acids, is believed to play essential roles in lipid metabolism. Structure activity relationship studies based on HTS
Autor:
Masatsugu Ohara, Kazuharu Suzuki, Jun-ichi Furukawa, Tomoe Kobayashi, Kenichi Higashino, Takashi Meguro, Kenichi Morikawa, Takuya Sho, Masaru Baba, Akihisa Nakamura, Manabu Onodera, Megumi Hato, Masato Nakai, Ken Furuya, Koji Ogawa, Naoki Kawagishi, Takashi Kobayashi, Takahiro Horimoto, Keisuke Shinada, Seiji Tsunematsu, Katsumi Terashita, Machiko Umemura, Hisatoshi Hanamatsu, Naoya Sakamoto, Yasuro Shinohara, Izumi Tsunematsu, Tomoko Mitsuhashi, Goki Suda
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD) that may lead to liver cirrhosis or hepatocellular carcinoma. Here, we examined the diagnostic utility of tri-antennary tri-sialylated mono-fucosy
Publikováno v:
Angewandte Chemie. 124:3442-3446
Inhibited: N-acetylglucosamine (GlcNAc) derivatives with a fluorine atom at the C4 position (2-4) were synthesized, and their ability to inhibit cancer-cell growth was investigated. The administration of these 4F-GlcNAc derivatives to cells led to th
Autor:
Norimasa Iwasaki, Shin-Ichiro Nishimura, Naoki Seito, Tomoya Matsuhashi, Maho Amano, Megumi Hato, Tomohiro Onodera, Atsushi Urita, Hiroaki Nakagawa, Akio Minami
Publikováno v:
Arthritis & Rheumatism. 63:3428-3438
Objective The process of N-glycosylation is involved in the pathogenesis of various diseases. However, little is known about the contribution of changes in N-glycans in osteoarthritis (OA). The aim of this study was to identify the alterations in N-g
Publikováno v:
Journal of separation science. 31(9)
HPLC/MS is now an essential method for the analysis of glycans and glycopeptides. A technique using ICATs is also becoming popular for their comparative/quantitative analysis based on MS signal intensities. However, the RP HPLC most often used causes
Autor:
Shin-Ichiro Nishimura, Satoru Todo, Masaki Kurogochi, Yoshiaki Miura, Megumi Hato, Jun-ichi Furukawa, Michitaka Ozaki, Hideyuki Shimaoka, Mitsuhiro Tada, Hiromitsu Kuramoto, Yasuro Shinohara, Kazuaki Nakanishi
Publikováno v:
Molecularcellular proteomics : MCP. 7(2)
Recent progress in mass spectrometry has led to new challenges in glycomics, including the development of rapid glycan enrichment techniques. A facile technique for exploration of a carbohydrate-related biomarker is important because proteomics resea
Autor:
Megumi Hato, Akio Minami, Shin-Ichiro Nishimura, Tomoya Matsuhashi, Norimasa Iwasaki, Hiroaki Nakagawa, Tokifumi Majima, Masaki Kurogochi
Publikováno v:
Osteoarthritis and cartilage. 16(7)
Summary Objective Osteoarthritis (OA) is the most common of all joint diseases, but the molecular basis of its onset and progression is controversial. Several studies have shown that modifications of N -glycans contribute to pathogenesis. However, li
Autor:
Keun-Young Kim, Luis C. Rios, Hiep Le, Alex J. Perez, Sébastien Phan, Eric A. Bushong, Thomas J. Deerinck, Yu Hsin Liu, Maya A. Ellisman, Varda Lev-Ram, Suyeon Ju, Sneha A. Panda, Sanghee Yoon, Masatoshi Hirayama, Ludovic S. Mure, Megumi Hatori, Mark H. Ellisman, Satchidananda Panda
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 628-644.e6 (2019)
Summary: The form and synaptic fine structure of melanopsin-expressing retinal ganglion cells, also called intrinsically photosensitive retinal ganglion cells (ipRGCs), were determined using a new membrane-targeted version of a genetic probe for corr
Externí odkaz:
https://doaj.org/article/5b8c699667c444cd980b9887fefdee26
Autor:
Hidemasa Torii, Toshihide Kurihara, Yuko Seko, Kazuno Negishi, Kazuhiko Ohnuma, Takaaki Inaba, Motoko Kawashima, Xiaoyan Jiang, Shinichiro Kondo, Maki Miyauchi, Yukihiro Miwa, Yusaku Katada, Kiwako Mori, Keiichi Kato, Kinya Tsubota, Hiroshi Goto, Mayumi Oda, Megumi Hatori, Kazuo Tsubota
Publikováno v:
EBioMedicine, Vol 15, Iss C, Pp 210-219 (2017)
Prevalence of myopia is increasing worldwide. Outdoor activity is one of the most important environmental factors for myopia control. Here we show that violet light (VL, 360–400 nm wavelength) suppresses myopia progression. First, we confirmed that
Externí odkaz:
https://doaj.org/article/7139060b87ca4ed6979cc720763b8207