Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Megumi Asada"'
Autor:
Megumi Asada-Utsugi, Makoto Urushitani
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7906 (2024)
Neurons in the brain are continuously exposed to various sources of DNA damage. Although the mechanisms of DNA damage repair in mitotic cells have been extensively characterized, the repair pathways in post-mitotic neurons are still largely elusive.
Externí odkaz:
https://doaj.org/article/ebb39be2c8bb4570b5c2aeafa9ae5ebf
Autor:
Sumio Minamiyama, Madoka Sakai, Yuko Yamaguchi, Makiko Kusui, Hideki Wada, Ryota Hikiami, Yoshitaka Tamaki, Megumi Asada-Utsugi, Akemi Shodai, Akiko Makino, Noriko Fujiwara, Takashi Ayaki, Takakuni Maki, Hitoshi Warita, Masashi Aoki, Keizo Tomonaga, Ryosuke Takahashi, Makoto Urushitani
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 312-329 (2023)
Superoxide dismutase1 (SOD 1) mutation is a leading cause of familial amyotrophic lateral sclerosis (ALS). Growing evidence suggests that antibody therapy against misfolded SOD1 protein can be therapeutic. However, the therapeutic effects are limited
Externí odkaz:
https://doaj.org/article/125f475f713e45e783a43ac5eb717f6d
Autor:
Ryota Hikiami, Toshifumi Morimura, Takashi Ayaki, Tomoyuki Tsukiyama, Naoko Morimura, Makiko Kusui, Hideki Wada, Sumio Minamiyama, Akemi Shodai, Megumi Asada-Utsugi, Shin-ichi Muramatsu, Takatoshi Ueki, Ryosuke Takahashi, Makoto Urushitani
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Genetic mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). Although mitochondrial dysfunction and stress granule have been crucially implicated in FUS proteinopathy, the molecular basis remains unclear. Here, we s
Externí odkaz:
https://doaj.org/article/466c0b9b2b744c3492877408d329cf97
Autor:
Megumi Asada-Utsugi, Kengo Uemura, Takashi Ayaki, Maiko T. Uemura, Sumio Minamiyama, Ryota Hikiami, Toshifumi Morimura, Akemi Shodai, Takatoshi Ueki, Ryosuke Takahashi, Ayae Kinoshita, Makoto Urushitani
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Phosphorylated microtubule-associated protein tau (p-tau) accumulates at double-strand breaks (DSBs) in neurons. Loss of tau induces failure of DSB repair and excessive DSB accumulation, leading to aberrant p-tau aggregation and apoptotic neurons.
Externí odkaz:
https://doaj.org/article/de0adf46df324e2681f7db4538e8e628
Autor:
Masato Maesako, Maiko Uemura, Yoshitaka Tashiro, Kazuki Sasaki, Kiwamu Watanabe, Yasuha Noda, Karin Ueda, Megumi Asada-Utsugi, Masakazu Kubota, Katsuya Okawa, Masafumi Ihara, Shun Shimohama, Kengo Uemura, Ayae Kinoshita
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0131199 (2015)
Obesity and type 2 diabetes are risk factors of Alzheimer's disease (AD). We reported that a high fat diet (HFD) promotes amyloid precursor protein (APP) cleavage by β-site APP cleaving enzyme 1 (BACE1) without increasing BACE1 levels in APP transge
Externí odkaz:
https://doaj.org/article/d3c1b127c225412f90873488877015f6
Autor:
Masato Maesako, Kengo Uemura, Ayana Iwata, Masakazu Kubota, Kiwamu Watanabe, Maiko Uemura, Yasuha Noda, Megumi Asada-Utsugi, Takeshi Kihara, Ryosuke Takahashi, Shun Shimohama, Ayae Kinoshita
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72796 (2013)
High fat diet (HFD) is prevalent in many modern societies and HFD-induced metabolic condition is a growing concern worldwide. It has been previously reported that HFD clearly worsens cognitive function in amyloid precursor protein (APP) transgenic mi
Externí odkaz:
https://doaj.org/article/c2d2ff48a9e146ce8777a0e2526ed31d
Autor:
Masaki Sone, Atsuko Uchida, Ayumi Komatsu, Emiko Suzuki, Ikue Ibuki, Megumi Asada, Hiroki Shiwaku, Takuya Tamura, Mikio Hoshino, Hitoshi Okazawa, Yo-ichi Nabeshima
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4466 (2009)
BACKGROUND: The subcellular localization of membrane and secreted proteins is finely and dynamically regulated through intracellular vesicular trafficking for permitting various biological processes. Drosophila Amyloid precursor protein like (APPL) a
Externí odkaz:
https://doaj.org/article/8dfaaa15d9334819855b2517de07df5b
Autor:
Hideki Wada, Ryota Hikiami, Makiko Kusui, Sumio Minamiyama, Megumi Asada-Utsugi, Akemi Shodai, Shin-ichi Muramatsu, Toshifumi Morimura, Makoto Urushitani
Publikováno v:
Neuroscience research.
Mislocalization and aggregate formation of TAR DNA-biding protein of 43kD (TDP-43) in the cytoplasm are signatures of amyotrophic lateral sclerosis(ALS) and frontotemporal lobar degeneration (FTLD). However, the role of two cytopathologies in ALS/FTL
Publikováno v:
IEICE Transactions on Communications.
Publikováno v:
2021 IEEE 94th Vehicular Technology Conference (VTC2021-Fall).