Výsledky vyhledávání - "Megumi Akiyoshi"

Reactions of community members regarding community health workers’ activities as a measure of the impact of a training program in Amazonas, Brazil

Autor: Mika Nishihara, Mayumi Ohnishi, Megumi Akiyoshi, Terezinha Ferreira de Almeida, Toshiro Yoshimura, Toru Sadamori, Ryoko Kawasaki

Publikováno v: Journal of Rural Medicine : JRM

Objectives: The aim of this study was to evaluate the impact of community health worker (CHW) training on recognition and satisfaction regarding the performance of CHWs among members of the community in Amazonas, Brazil, which is a resource-poor area

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7f960c67ac2f13918d5dd8d2efbd44
https://doi.org/10.2185/jrm.2890

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Pharmacological and clinical properties of levocabastine hydrochloride (eye drop and nasal spray), a selective H1 antagonist

Autor: Tsunehiko Shigeoka, Shinichi Torii, Hiromasa Takahashi, Eiji Maki, Megumi Akiyoshi, Satoru Enomoto, Fumiya Hirano

Publikováno v: Folia Pharmacologica Japonica. 119:175-184

Levocabastine is a selective histamine H1-receptor antagonist exerting inhibitory effects on the release of chemical mediators from mast cells and on the chemotaxis of polymorphonuclear leukocytes and eosinophils. Both histamine and antigens induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ec7a974d282cfe2c053ff953b77703
https://doi.org/10.1254/fpj.119.175

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Kinetic Analysis of Successive Reactions Catalyzed by Bovine Cytochrome P45017α,lyase

Autor: Megumi Akiyoshi-Shibata, Toshiyuki Sakaki, Shiro Kominami, Takeshi Yamazaki, Tadashi Imai, Yoshiyasu Yabusaki, Takashi Ohno

Publikováno v: Biochemistry. 37:2800-2806

Bovine P450(17alpha,lyase) containing an additional four histidine residues at the COOH terminus was expressed in Escherichia coli and purified by one-step column chromatography using Ni-chelate resin. The membrane enzyme was incorporated into liposo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cdbd8ad3352c22719365a6d3d08089b
https://doi.org/10.1021/bi9715066

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Molecular Engineering Study on Electron Transfer from NADPH-P450 Reductase to Rat Mitochondrial P450c27 in Yeast Microsomes

Autor: Shiro Kominami, Koji Hayashi, Toshiyuki Sakaki, Megumi Akiyoshi-Shibata, Yoshiyasu Yabusaki

Publikováno v: Journal of Biological Chemistry. 271:26209-26213

We have reported the localization on yeast microsomes for a modified P450c27 (mic-P450c27) that contains the microsomal targeting signal of bovine P450c17 in front of the mature form of rat mitochondrial P450c27 (Sakaki, T., Akiyoshi-Shibata, M., Yab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d8f2de903e86ebd6b0ee2598c1ed4d
https://doi.org/10.1074/jbc.271.42.26209

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Somatostatin and insulin secretion due to common mechanisms by a new hypoglycemic agent, A-4166, in perfused rat pancreas

Autor: Toshio Maki, Megumi Akiyoshi, Toshihiko Yada, Takao Ikenoue, Shoji Fujitani

Publikováno v: Metabolism. 45:184-189

N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166) is a nonsulfonylurea hypoglycemic agent that decreases blood glucose levels in nondiabetic and diabetic animals. In the present study, we attempted to determine the effect of A-4166

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c593bf59384128036e1621d5fc92bb
https://doi.org/10.1016/s0026-0495(96)90051-7

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Further Oxidation of Hydroxycalcidiol by Calcidiol 24-Hydroxylase. A Study with the Mature Enzyme Expressed in Escherichia coli

Autor: Yoshiyasu Yabusaki, Kyuichiro Okuda, Toshiyuki Sakaki, Mitsuhide Noshiro, Megumi Akiyoshi-Shibata, Yoshihiko Ohyama

Publikováno v: European Journal of Biochemistry. 224:335-343

The coding region of the cDNA for rat kidney calcidiol 24-hydroxylase (P450cc24), which is involved in calcium homeostasis in animals, was inserted into an expression vector pKK223-3. The recombinant plasmid was formed in a specific manner without de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e11a20b63499b73611f787814bc89f
https://doi.org/10.1111/j.1432-1033.1994.00335.x

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Kinetic Studies on a Genetically Engineered Fused Enzyme between Rat Cytochrome P4501A1 and Yeast NADPH-P450 Reductase

Autor: Shigeki Takemori, Toshiyuki Sakaki, Hideo Ohkawa, Shiro Kominami, Megumi Akiyoshi-Shibata, Yoshiyasu Yabusaki

Publikováno v: Biochemistry. 33:4933-4939

Three expression plasmids, pAMC1 for rat P4501A1, pAMR2 for P4501A1 and yeast NADPH-P450 reductase, and pAFCR1 for a fused enzyme between P4501A1 and the reductase, were constructed, and each was introduced into Saccharomyces cerevisiae AH22 cells. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea155c1fbb74641722de2df73a640d95
https://doi.org/10.1021/bi00182a023

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Progesterone metabolism in recombinant yeast simultaneously expressing bovine cytochromes P450cl7 (CYP17A1) and P450c21 (CYP21B1) and yeast NADPH-P450 oxidoreductase

Autor: Toshiyuki Sakaki, Hiroko Murakami, Kayo Manabe, Megumi Akiyoshi-Shibata, Hideo Ohkawa, Yoshiyasu Yabusaki

Publikováno v: Pharmacogenetics. 1:86-93

Simultaneous expression plasmids were constructed for bovine adrenal cytochromes P450c17 and P450c21 (pA gamma alpha) and for both P450s together with NADPH-cytochrome P450 reductase (pAR gamma alpha). On introduction of each of the plasmids into Sac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0716e7ceb8e8d6a05f4f890ada819e7c
https://doi.org/10.1097/00008571-199111000-00005

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