Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Megumi Aimoto"'
Autor:
Kento Watanabe, Tomoaki Shiba, Akira Takahara, Hiroshi Homma, Tetsuya Komatsu, Yusuke Tanino, Yoshinobu Nagasawa, Megumi Aimoto, Yuichi Hori
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract This study aimed to investigate the feasibility of utilizing noninvasive ocular blood flow measurements as potential indicators of systemic circulation in rabbits experiencing hemorrhagic shock. Using Laser speckle flowgraphy, ocular blood f
Externí odkaz:
https://doaj.org/article/672fedb0325641fba19df7c896ac75c4
Autor:
Satoshi Kawakami, Ryuichi Kambayashi, Kazuhiro Takada, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 2, Pp 67-73 (2022)
We analyzed role of cardiac α1-adrenoreceptors for the torsadogenic action of IKr blocker nifekalant in isoflurane-anesthetized atrioventricular block rabbits. Bradycardia was induced by atrioventricular node ablation, and the ventricle was electric
Externí odkaz:
https://doaj.org/article/e883ec64e945443eaffa5eabe4cb4081
Autor:
Yoshinobu Nagasawa, Akira Shimoda, Hiroki Shiratori, Takenori Morishita, Kiyoshi Sakuma, Tatsuo Chiba, Xin Cao, Satoshi Kawakami, Megumi Aimoto, Chikao Miyazaki, Shuji Sato, Mao Takahashi, Kazuhiro Shimizu, Kohji Shirai, Akira Takahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 3, Pp 331-336 (2022)
Although elasticity of the conduit arteries is known to be contribute effective peripheral circulation via Windkessel effects, the relationship between changes in intra-aortic blood volume and conduit artery elasticity remains unknown. Here we assess
Externí odkaz:
https://doaj.org/article/7d7f47fb3273427aa2229e3d8684df7f
Autor:
Satoshi Kawakami, Yoshinobu Nagasawa, Mihoko Hagiwara-Nagasawa, Kensuke Omura, Megumi Aimoto, Akira Takahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 144, Iss 3, Pp 123-128 (2020)
We assessed the torsadogenic effects of a novel remyelinating drug clemastine for multiple sclerosis using an in vivo proarrhythmia model of acute atrioventricular block rabbit, since the drug has been demonstrated to suppress the human ether-á-go-g
Externí odkaz:
https://doaj.org/article/073f1c7cd59d41c29f19d84fdadf157c
Autor:
Yoshinobu Nagasawa, Kaori Sakai, Rui Kurimoto, Satoshi Kawakami, Megumi Aimoto, Akira Takahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 1, Pp 39-44 (2020)
We investigated effects of isoflurane and sevoflurane on sparfloxacin-induced QT-interval prolongation in guinea pigs under the monitoring of electrocardiogram and monophasic action potential (MAP), which was compared with those of halothane or non-i
Externí odkaz:
https://doaj.org/article/059e03940d0a4d4a9de05c3156ee6a94
Publikováno v:
Journal of Pharmacological Sciences, Vol 142, Iss 1, Pp 34-40 (2020)
Atrial dilation is an independent risk factor for the development of atrial fibrillation (AF) and modulates the efficacy of anti-AF drugs, leading to the unsatisfactory control of AF. Pre-clinical studies showed anti-AF effects of acehytisine, a mult
Externí odkaz:
https://doaj.org/article/5fec907baf0b47ad9931a27942314ece
Publikováno v:
Journal of Pharmacological Sciences, Vol 141, Iss 4, Pp 153-159 (2019)
Experimental evidence regarding the risk of proarrhythmic potential of acehytisine is limited. We assessed its electropharmacological effect together with proarrhythmic potential at intravenous doses of 4 and 10 mg/kg (n = 6) using isoflurane-anesthe
Externí odkaz:
https://doaj.org/article/ba52a1dff6c04d0fa95f0fa1effc4974
Autor:
Kiyoshi Sakuma, Akira Shimoda, Hiroaki Shiratori, Tetsuya Komatsu, Kento Watanabe, Tatsuo Chiba, Megumi Aimoto, Yoshinobu Nagasawa, Yuichi Hori, Kohji Shirai, Akira Takahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 2, Pp 205-209 (2019)
The cardio-ankle vascular index (CAVI) has been established as a stiffness indicator from thoracic aorta to tibial arteries. To better understand physiological regulatory factors for the arterial stiffness, we assessed effects of angiotensin II and a
Externí odkaz:
https://doaj.org/article/414c82dda04a4e4db83558f16746122d
Autor:
Tatsuo Chiba, Kiyoshi Sakuma, Tetsuya Komatsu, Xin Cao, Megumi Aimoto, Yoshinobu Nagasawa, Kazuhiro Shimizu, Mao Takahashi, Yuichi Hori, Kohji Shirai, Akira Takahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 1, Pp 42-45 (2019)
We assessed effects of acetylcholine and Nω-Nitro-l-arginine methyl ester hydrochloride (l-NAME) on the cardio-ankle vascular index (CAVI), an indicator of arterial stiffness from origin of aorta to tibial artery, in halothane-anesthetized rabbits.
Externí odkaz:
https://doaj.org/article/5d8d51a092f74d4ca3cbc7474c847675
Publikováno v:
Journal of Pharmacological Sciences, Vol 136, Iss 2, Pp 73-78 (2018)
Whereas molecular mechanisms of atrial fibrillation (AF) have been widely investigated, there is limited information regarding interrelation between chronic volume overload and parasympathetic nervous system in the pathophysiology of AF. In this stud
Externí odkaz:
https://doaj.org/article/eff04073ab4e4cb8819a772c5c629795