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of 67
pro vyhledávání: '"Megumi, Shimoyama"'
Publikováno v:
Chemical biologydrug designREFERENCES.
Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of several anticancer agents including paclitaxel, a chemotherapeutic drug widely used in cancer treatment. CIPN deteriorates patients' quality of life and compromises cancer tr
Autor:
Naohito Shimoyama, Megumi Shimoyama
Publikováno v:
THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA. 38:783-789
Autor:
Yugo Tagaito, Naohito Shimoyama, Hiroshi Nagase, Satoshi Toyama, Tsuyoshi Saitoh, Masashi Yanagisawa, Megumi Shimoyama
Publikováno v:
Anesthesiology. 128:992-1003
Background Sleepiness and decrease in attention are dose-limiting side effects of opioids. The orexin/hypocretin system plays an important role in maintaining wakefulness. This study aimed to explore the potential of a nonpeptide orexin receptor agon
Autor:
Megumi, Shimoyama, Naohito, Shimoyama
Publikováno v:
Masui. The Japanese journal of anesthesiology. 65(11)
Recently in Japan, more patients are receiving chronic opioid therapy for cancer pain or chronic pain, and there is an increasing number of such patients presenting for surgery. The anesthesiologist should be familiar with available opioid formulatio
Publikováno v:
ACS chemical neuroscience. 9(7)
Several chemotherapeutic agents used for cancer treatment induce dose-limiting peripheral neuropathy that compromises patients’ quality of life and limits cancer treatment. Recently, mitochondrial dysfunction has been shown to be involved in the me
Autor:
Kanefumi Matsuoka, Megumi Shimoyama
Publikováno v:
Palliative Care Research. 10:501-504
Publikováno v:
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 36(8)
Publikováno v:
Chemical Biology & Drug Design. 80:771-774
H-Dmt-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA) is a synthetic tetrapeptide with extraordinary selectivity for the mu-opioid receptor and is an extremely potent analgesic. [Dmt(1) ]DALDA is unusual in the way that the greater part of its analgesic potency
Publikováno v:
Pharmacology. 89:145-148
Background/Aims: Multiple opioid receptor (OR) types and endogenous opioid peptides exist in the spinal dorsal horn and there may be interactions among these receptor types that involve opioid peptides. In a previous study we observed that antinocice
Publikováno v:
Acta Anaesthesiologica Scandinavica. 56:256-259
We report an unusual case of massive macroglossia that developed very rapidly after neurosurgery in the park bench position with neck flexion. A few minutes after endotracheal extubation, massive macroglossia was noticed with marked protrusion of the