Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Meghna Waghray"'
Autor:
Ethan V Abel, Masashi Goto, Brian Magnuson, Saji Abraham, Nikita Ramanathan, Emily Hotaling, Anthony A Alaniz, Chandan Kumar-Sinha, Michele L Dziubinski, Sumithra Urs, Lidong Wang, Jiaqi Shi, Meghna Waghray, Mats Ljungman, Howard C Crawford, Diane M Simeone
Publikováno v:
eLife, Vol 7 (2018)
The biological properties of pancreatic cancer stem cells (PCSCs) remain incompletely defined and the central regulators are unknown. By bioinformatic analysis of a human PCSC-enriched gene signature, we identified the transcription factor HNF1A as a
Externí odkaz:
https://doaj.org/article/c0bbaf7b2d6f42a3bacb5bc20116432e
Autor:
Erica Proctor, Meghna Waghray, Cheong Jun Lee, David G Heidt, Malica Yalamanchili, Chenwei Li, Filip Bednar, Diane M Simeone
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55820 (2013)
Bmi1 is an integral component of the Polycomb Repressive Complex 1 (PRC1) and is involved in the pathogenesis of multiple cancers. It also plays a key role in the functioning of endogenous stem cells and cancer stem cells. Previous work implicated a
Externí odkaz:
https://doaj.org/article/c0c32746e6bd4e37aa80a9740272ec50
Autor:
Milena Saqui-Salces, Evelyn Covés-Datson, Natalia A Veniaminova, Meghna Waghray, Li-Jyun Syu, Andrzej A Dlugosz, Juanita L Merchant
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48039 (2012)
Chronic inflammation in the stomach can lead to gastric cancer. We previously reported that gastrin-deficient (Gast⁻/⁻) mice develop bacterial overgrowth, inflammatory infiltrate, increased Il-1β expression, antral hyperplasia and eventually ant
Externí odkaz:
https://doaj.org/article/26913f65ec324e45ae2ca298f8855be0
Autor:
Diane M. Simeone, Lidong Wang, Sunitha Nagrath, Vaibhav Sahai, Ethan V. Abel, Phillip L. Palmbos, Theodore H. Welling, Marina Pasca Di Magliano, Sumithra Urs, Kara A. Schradle, Huibin Yang, Marguerite Erkkinen, Mina Zeinali, Michele Dziubinski, Malica Yalamanchili, Meghna Waghray
Supplementary Table 1. Percentage of CA-MSCs (CD44+CD73+CD49α+ CD90+) from primary human pancreatic cancer derived CAF cultures and accompanying clinical data. Supplementary Table 2. Extent of local invasion, lung tumor emboli, and liver metastasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3288f723cc4a79743126cde29399425
https://doi.org/10.1158/2159-8290.22531460.v1
https://doi.org/10.1158/2159-8290.22531460.v1
Autor:
Diane M. Simeone, Lidong Wang, Sunitha Nagrath, Vaibhav Sahai, Ethan V. Abel, Phillip L. Palmbos, Theodore H. Welling, Marina Pasca Di Magliano, Sumithra Urs, Kara A. Schradle, Huibin Yang, Marguerite Erkkinen, Mina Zeinali, Michele Dziubinski, Malica Yalamanchili, Meghna Waghray
Supplementary Figure 2. Pancreatic cancer associated MSCs promote tumor cell growth and invasion. A. GFP-labeled tumor cells were grown alone or co-cultured with CA-MSCs or CAFs. GFP-labeled tumor cells were grown in growth media, in combination with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e729a8889cedd94aaeeec164569b45
https://doi.org/10.1158/2159-8290.22531478
https://doi.org/10.1158/2159-8290.22531478
Autor:
Diane M. Simeone, Lidong Wang, Sunitha Nagrath, Vaibhav Sahai, Ethan V. Abel, Phillip L. Palmbos, Theodore H. Welling, Marina Pasca Di Magliano, Sumithra Urs, Kara A. Schradle, Huibin Yang, Marguerite Erkkinen, Mina Zeinali, Michele Dziubinski, Malica Yalamanchili, Meghna Waghray
Supplementary Figure 7. A. Sections from orthotopic pancreatic tumors from control shRNA- MSC vs GM-CSF-shRNA-MSC were analyzed for expression of F4/80, and Arg1 by immunohistochemical and immunofluorescence staining. B. Quantitation of F4/80 positiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2500a2cff01f922bcfd909812090a5d6
https://doi.org/10.1158/2159-8290.22531463
https://doi.org/10.1158/2159-8290.22531463
Autor:
Diane M. Simeone, Lidong Wang, Sunitha Nagrath, Vaibhav Sahai, Ethan V. Abel, Phillip L. Palmbos, Theodore H. Welling, Marina Pasca Di Magliano, Sumithra Urs, Kara A. Schradle, Huibin Yang, Marguerite Erkkinen, Mina Zeinali, Michele Dziubinski, Malica Yalamanchili, Meghna Waghray
Supplementary Figure 5. Representative Western blot demonstrating the expression of GM-CSF receptors CSF2Rα and CSF2Rβ in primary human pancreatic cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f19fbf099512f43d6800df6b994c468
https://doi.org/10.1158/2159-8290.22531469.v1
https://doi.org/10.1158/2159-8290.22531469.v1
Autor:
Diane M. Simeone, Lidong Wang, Sunitha Nagrath, Vaibhav Sahai, Ethan V. Abel, Phillip L. Palmbos, Theodore H. Welling, Marina Pasca Di Magliano, Sumithra Urs, Kara A. Schradle, Huibin Yang, Marguerite Erkkinen, Mina Zeinali, Michele Dziubinski, Malica Yalamanchili, Meghna Waghray
Supplementary Figure 6. Pancreatic CA-MSCs promote tumor sphere formation. GFP-labeled tumor cells were grown in growth media, in combination with CM from CA-MSCs and CM from CAFs or co-cultured with CA-MSCs or CAFs (red). Enhanced size of tumor sphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d38ae0a889bdd8f008bed48afe0476
https://doi.org/10.1158/2159-8290.22531466.v1
https://doi.org/10.1158/2159-8290.22531466.v1
Autor:
Diane M. Simeone, Lidong Wang, Sunitha Nagrath, Vaibhav Sahai, Ethan V. Abel, Phillip L. Palmbos, Theodore H. Welling, Marina Pasca Di Magliano, Sumithra Urs, Kara A. Schradle, Huibin Yang, Marguerite Erkkinen, Mina Zeinali, Michele Dziubinski, Malica Yalamanchili, Meghna Waghray
Supplementary Figure 1. A. FACS analysis of freshly digested pancreatic tumor tissue from two different PDA patients (left) and outgrown CAFs from matching patients cultured using the outgrowth method for 2 weeks (right), demonstrating the percentage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aeb5b074016a6f57d214401efb555e4
https://doi.org/10.1158/2159-8290.22531481
https://doi.org/10.1158/2159-8290.22531481
Autor:
Diane M. Simeone, Lidong Wang, Sunitha Nagrath, Vaibhav Sahai, Ethan V. Abel, Phillip L. Palmbos, Theodore H. Welling, Marina Pasca Di Magliano, Sumithra Urs, Kara A. Schradle, Huibin Yang, Marguerite Erkkinen, Mina Zeinali, Michele Dziubinski, Malica Yalamanchili, Meghna Waghray
Supplementary Figure 4. Differential secretion of cytokines by CA-MSC and CAFs from four different patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056c770e9e82e49f9dcc60d17997c9b3
https://doi.org/10.1158/2159-8290.22531472.v1
https://doi.org/10.1158/2159-8290.22531472.v1