Comparison of regional brain deficit patterns in common psychiatric and neurological disorders as revealed by big data

Autor: Peter Kochunov, Meghann C. Ryan, Qifan Yang, Kathryn S. Hatch, Alyssa Zhu, Sophia I. Thomopoulos, Neda Jahanshad, Lianne Schmaal, Paul M. Thompson, Shuo Chen, Xiaoming Du, Bhim M. Adhikari, Heather Bruce, Stephanie Hare, Eric L. Goldwaser, Mark D. Kvarta, Thomas E. Nichols, L. Elliot Hong

Publikováno v: NeuroImage: Clinical, Vol 29, Iss , Pp 102574- (2021)

Neurological and psychiatric illnesses are associated with regional brain deficit patterns that bear unique signatures and capture illness-specific characteristics. The Regional Vulnerability Index (RVI) was developed to quantify brain similarity by

Externí odkaz: https://doaj.org/article/8692a3ac71b54b57b3d2196227216365

The additive impact of cardio‐metabolic disorders and psychiatric illnesses on accelerated brain aging

Autor: Meghann C. Ryan, L. Elliot Hong, Kathryn S. Hatch, Si Gao, Shuo Chen, Krystl Haerian, Jingtao Wang, Eric L. Goldwaser, Xiaoming Du, Bhim M. Adhikari, Heather Bruce, Stephanie Hare, Mark D. Kvarta, Neda Jahanshad, Thomas E. Nichols, Paul M. Thompson, Peter Kochunov

Publikováno v: Human Brain Mapping. 43:1997-2010

Severe mental illnesses (SMI) including major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum disorder (SSD) elevate accelerated brain aging risks. Cardio-metabolic disorders (CMD) are common comorbidities in SMI and nega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d3311977d5f08769ba80af81f91c0e
https://doi.org/10.1002/hbm.25769

Ongoing oxidative stress in individuals with post-acute sequelae of COVID-19

Autor: Muhammad G. Saleh, Linda Chang, Huajun Liang, Meghann C. Ryan, Eric Cunningham, Jonathan Garner, Eleanor Wilson, Andrea R. Levine, Shyamasundaran Kottilil, Thomas Ernst

Publikováno v: NeuroImmune Pharmacology and Therapeutics.

Objectives Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is associated with lower plasma glutathione (GSH) levels due to oxidative stress. However, plasma levels may not reflect brain GSH levels. Individuals with post-acute seque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38b766b23173ea9e529afae244bafd29
https://doi.org/10.1515/nipt-2022-0006

ENIGMA-DTI:Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research

Autor: Carrie E. Bearden, Gianfranco Spalletta, Paul M. Thompson, Meghann C. Ryan, Liz Haddad, Fabrizio Piras, Gary Donohoe, Talia M. Nir, Peter Kochunov, David C. Glahn, Josselin Houenou, David F. Tate, Rajendra A. Morey, Odile A. van den Heuvel, L. Elliot Hong, Mark W. Logue, Pauline Favre, Laurena Holleran, Theo G.M. van Erp, Ole A. Andreassen, Sinead Kelly, Emily L. Dennis, Dan J. Stein, Yunlong Tan, Christopher R.K. Ching, Neda Jahanshad, Lianne Schmaal, Elisabeth A. Wilde, Laura S van Velzen, Jessica A. Turner, Julio E. Villalon-Reina, Dick J. Veltman

Publikováno v: Kochunov, P, Hong, L E, Dennis, E L, Morey, R A, Tate, D F, Wilde, E A, Logue, M, Kelly, S, Donohoe, G, Favre, P, Houenou, J, Ching, C R K, Holleran, L, Andreassen, O A, van Velzen, L S, Schmaal, L, Villalón-Reina, J E, Bearden, C E, Piras, F, Spalletta, G, van den Heuvel, O A, Veltman, D J, Stein, D J, Ryan, M C, Tan, Y, van Erp, T G M, Turner, J A, Haddad, L, Nir, T M, Glahn, D C, Thompson, P M & Jahanshad, N 2022, ' ENIGMA-DTI : Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research ', Human Brain Mapping, vol. 43, no. 1, pp. 194-206 . https://doi.org/10.1002/hbm.24998
Human Brain Mapping

The ENIGMA‐DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and developmental disorders on the white matter pathways of the human brain, as well as the effects of normal variation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1807a29555dc09cad8725b7b7c990bd
https://research.vumc.nl/en/publications/1f1cb2ba-1241-4d23-86ea-acaf5273f9f9

Choroid Plexus Enlargement and Allostatic Load in Schizophrenia

Autor: Shuping Tan, Fengmei Fan, Ping Zhang, Song Chen, Yimin Cui, Meghann C. Ryan, Laura M. Rowland, Anya Savransky, Eric L. Goldwaser, Xingguang Luo, Ying Yuan, Yanfang Zhou, Wei Feng, Joshua Chiappelli, Peter Kochunov, Fude Yang, Junchao Huang, Zhiren Wang, L. Elliot Hong, Yunlong Tan, Hongzhen Fan

Publikováno v: Schizophr Bull

Although schizophrenia is a brain disorder, increasing evidence suggests that there may be body-wide involvement in this illness. However, direct evidence of brain structures involved in the presumed peripheral-central interaction in schizophrenia is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ce94bfbb1eab8f5eb7bdbb4e842ecf
https://doi.org/10.1093/schbul/sbz100