Výsledky vyhledávání - "Meghana B. Kamath"

Dose-dependent repression of T-cell and natural killer cell genes by PU.1 enforces myeloid and B-cell identity

Autor: Xiang Zhu, Meghana B. Kamath, Anil G. Jegga, Sivakumar Gowrisankar, A J Janovski, Rodney P. DeKoter, Isaac B. Houston

Publikováno v: Leukemia. 22:1214-1225

The Ets transcription factor PU.1, encoded by the gene Sfpi1, functions in a concentration-dependent manner to promote myeloid and B-cell development and has been implicated in myeloid and lymphoid leukemias. To determine the consequences of reducing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48acf105e70612a2728afdad2236e52c
https://doi.org/10.1038/leu.2008.67

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Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models

Autor: Isaac B. Houston, Rodney P. DeKoter, Meghana B. Kamath

Publikováno v: Blood Cells, Molecules, and Diseases. 39:316-320

The Ets family transcription factor PU.1, encoded by the gene Sfpi1 , is essential for normal hematopoiesis. A number of studies have suggested that changes in PU.1 concentration play a role in directing cell fate decisions during hematopoiesis. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230d491966fffe48e5dd73d14cb89e18
https://doi.org/10.1016/j.bcmd.2007.06.004

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Regulation of the Interleukin-7 Receptor α Promoter by the Ets Transcription Factors PU.1 and GA-binding Protein in Developing B Cells

Autor: Darrel Jones, Kelly J. Huang, Rodney P. DeKoter, Brock L. Schweitzer, David A. Hildeman, Constanze Bonifer, Meghana B. Kamath, Hiromi Tagoh

Publikováno v: Journal of Biological Chemistry. 282:14194-14204

Signaling through the IL-7 receptor (IL-7R) is required for development and maintenance of the immune system. The receptor for IL-7 is heterodimeric, consisting of a common gamma chain (gammac, encoded by Il2rg) and an alpha subunit (IL-7Ralpha, enco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b793cc60b71d0d2cfb74f4d503317f
https://doi.org/10.1074/jbc.m700377200

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Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality

Autor: Isaac B. Houston, Brock L. Schweitzer, Rodney P. DeKoter, Timothy M. Chlon, Meghana B. Kamath

Publikováno v: Experimental hematology. 35(7)

Objective It has been demonstrated that high concentration of the transcription factor PU.1 (encoded by Sfpi1 ) promotes macrophage development, whereas low concentration induces B-cell development in vitro. This has led to the hypothesis that lower

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d6bdf9924fc3ea48b54d0776b9d51a
https://pubmed.ncbi.nlm.nih.gov/17588474

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Spi-C has opposing effects to PU.1 on gene expression in progenitor B cells

Autor: Brock L. Schweitzer, Kelly J. Huang, Rodney P. DeKoter, Alexander Emelyanov, Barbara K. Birshtein, Meghana B. Kamath

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 177(4)

The Ets transcription factor Spi-C, expressed in B cells and macrophages, is closely related to PU.1 and has the ability to recognize the same DNA consensus sequence. However, the function of Spi-C has yet to be determined. The purpose of this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b36a78d22970cdb0fc4d53dfed4f3ad
https://pubmed.ncbi.nlm.nih.gov/16887979

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Myeloid Gene Activation and T Cell/Natural Killer Cell Gene Repression in Cells Expressing Two Distinct PU.1 Concentrations

Autor: Sivakumar Gowrisankar, Xiang Zhu, Rodney P. DeKoter, Anil G. Jegga, Isaac B. Houston, Alexander Janovski, Meghana B. Kamath

Publikováno v: Blood. 110:1242-1242

The Ets transcription factor PU.1 (encoded by the gene Sfpi1) functions in a concentration-dependent manner as a hematopoietic cell fate determinant. PU.1 levels are uniform in early hematopoiesis, increase during myeloid differentiation, and decreas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d876c9c513591231de3e40e08d8afa05
https://doi.org/10.1182/blood.v110.11.1242.1242

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Hypomorphic Alleles of PU.1 Result in Impaired Myelopoiesis and Target Gene Expression

Autor: Meghana B. Kamath, Rodney P. DeKoter, Brock L. Schweitzer, Jennifer K. Ondr, Timothy M. Chlon, Isaac B. Houston

Publikováno v: Blood. 108:1180-1180

PU.1 is an Ets-family transcription factor that is critical for normal hematopoiesis. Knock-out studies of PU.1 demonstrate that it is required for the development of myeloid and lymphoid cells. PU.1 is expressed at graded levels in the immune system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3daadb9fdd9e10323a8444fdb31b1e6
https://doi.org/10.1182/blood.v108.11.1180.1180

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