Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Meghan M Painter"'
Autor:
Meghan M Painter, James H Morrison, Laurie J Zoecklein, Tommy A Rinkoski, Jens O Watzlawik, Louisa M Papke, Arthur E Warrington, Allan J Bieber, William E Matchett, Kari L Turkowski, Eric M Poeschla, Moses Rodriguez
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005311 (2015)
For many emerging and re-emerging infectious diseases, definitive solutions via sterilizing adaptive immunity may require years or decades to develop, if they are even possible. The innate immune system offers alternative mechanisms that do not requi
Externí odkaz:
https://doaj.org/article/a7744516c8e147598d583085c9739909
Autor:
Jens O Watzlawik, Robert J Kahoud, Ryan J O'Toole, Katherine A M White, Alyssa R Ogden, Meghan M Painter, Bharath Wootla, Louisa M Papke, Aleksandar Denic, Jill M Weimer, William A Carey, Moses Rodriguez
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128007 (2015)
Neonatal white matter injury (nWMI) is an increasingly common cause of cerebral palsy that results predominantly from hypoxic injury to progenitor cells including those of the oligodendrocyte lineage. Existing mouse models of nWMI utilize prolonged p
Externí odkaz:
https://doaj.org/article/4e8be402acda461b8f1c8ff02e22c4f0
Autor:
Guojun Bu, Li Zhong, Chia Chen Liu, Huaxi Xu, Lin Jia, Linbei Wu, Daxin Wang, Zongqi Wang, Zhe Wang, Xinxiu Li, Meghan M. Painter, Yun-wu Zhang, Xiao Fen Chen, Tingting Wang, Chunyan Liao, Yuka Atagi, Honghua Zheng, Ruizhi Huang, John D. Fryer
Publikováno v:
Journal of Experimental Medicine. 214:597-607
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed in microglia in the brain. A soluble form of TREM2 (sTREM2) derived from proteolytic cleavage of the cell surface receptor is increased in the preclinical
Autor:
Laurie Zoecklein, Arthur E. Warrington, Louisa Papke, Bharath Wootla, Moses Rodriguez, Robert J. Kahoud, William A. Carey, Shermayne Ng, Jens O. Watzlawik, Meghan M. Painter
Publikováno v:
Journal of Neurochemistry. 134:865-878
CNS regeneration is a desirable goal for diseases of brain and spinal cord. Current therapeutic strategies for the treatment of multiple sclerosis (MS) aim to eliminate detrimental effects of the immune system, so far without reversing disability or
Publikováno v:
Journal of nature and science. 1(8)
We previously identified a human monoclonal antibody, termed HIgM12 that stimulates spontaneous locomotor activity in a chronically demyelinating mouse model of multiple sclerosis. When tested as a molecular substrate, HIgM12 stimulated neurite outgr
Autor:
Jens O, Watzlawik, Robert J, Kahoud, Bharath, Wootla, Meghan M, Painter, Arthur E, Warrington, William A, Carey, Moses, Rodriguez
Publikováno v:
Journal of Visualized Experiments : JoVE
Antibodies of the IgM isotype are often neglected as potential therapeutics in human trials, animal models of human diseases as well as detecting agents in standard laboratory techniques. In contrast, several human IgMs demonstrated proof of efficacy
Autor:
Arthur E. Warrington, Moses Rodriguez, William A. Carey, Jens O. Watzlawik, Bharath Wootla, Robert J. Kahoud, Meghan M. Painter
Publikováno v:
Journal of Visualized Experiments.
Antibodies of the IgM isotype are often neglected as potential therapeutics in human trials, animal models of human diseases as well as detecting agents in standard laboratory techniques. In contrast, several human IgMs demonstrated proof of efficacy
Publikováno v:
CNS drugs. 30(9)
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that causes progressive cognitive decline. The majority of AD cases are sporadic and late-onset (>65 years old) making it the leading cause of dementia in the elderly. While both
Autor:
Julia E. Crook, Yu Yamazaki, Motoko Shinohara, Melissa E. Murray, Takahisa Kanekiyo, Ryan D. Frank, Meghan M. Painter, Mitsuru Shinohara, Chia Chen Liu, Dennis W. Dickson, John D. Fryer, Guojun Bu, Mary D. Davis, Na Zhao, Yuka Atagi, Ronald C. Petersen, Masaya Tachibana, Michael DeTure
Publikováno v:
Acta neuropathologica. 132(2)
Cerebral amyloid angiopathy (CAA) often coexists with Alzheimer's disease (AD). APOE4 is a strong genetic risk factor for both AD and CAA. Sex-dependent differences have been shown in AD as well as in cerebrovascular diseases. Therefore, we examined
Autor:
Melissa M. Schultz, Edward T. Furlong, Meghan M. Painter, Heiko L. Schoenfuss, Amanda Logue, Stephen L. Werner, Stephen E. Bartell
Publikováno v:
Aquatic Toxicology. 104:38-47
Antidepressant pharmaceuticals have been reported in wastewater effluent at the nanogram to low microgram-per-liter range, and include bupropion (BUP), fluoxetine (FLX), sertraline (SER), and venlafaxine (VEN). To assess the effects of antidepressant