Výsledky vyhledávání - "Meghan L. O'Neil"

Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge

Autor: Meghan L. O’Neil, Goran Lacan, William P. Melega, Arthur K. Cho, David S. Segal, Ronald Kuczenski

Publikováno v: Synapse. 60:465-473

A major feature of human methamphetamine (METH) abuse is the gradual dose escalation that precedes high-dose exposure. The period of escalating doses (EDs) is likely associated with development of tolerance to aspects of METH's pharmacologic and toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830081871a12f2852826452bf0559f0f
https://doi.org/10.1002/syn.20320

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Escalating Dose Methamphetamine Pretreatment Alters the Behavioral and Neurochemical Profiles Associated with Exposure to a High-Dose Methamphetamine Binge

Autor: David S. Segal, Ronald Kuczenski, William P. Melega, Arthur K. Cho, Meghan L. O’Neil

Publikováno v: Neuropsychopharmacology. 28:1730-1740

The neurotoxic effects of methamphetamine (METH) have been characterized primarily from the study of high-dose binge regimens in rodents. However, this drug administration paradigm does not include a potentially important feature of stimulant abuse i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab93fb96c350fcd1682b015ba5c1148
https://doi.org/10.1038/sj.npp.1300247

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