Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Meghan L Marre"'
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12871 (2010)
Toll-like receptor (TLR)-2/TLR1 heterodimers recognize bacterial lipopeptides and initiate the production of inflammatory mediators. Adaptors and co-receptors that mediate this process, as well as the mechanisms by which these adaptors and co-recepto
Externí odkaz:
https://doaj.org/article/9d23752ba1ba4485bfd9adf1da49688f
Autor:
Christina P. Martins, Noah W. Beck, Ashley V. Menk, Gina M. Coudriet, Rebecca H. Wright, Erin C. O’Connor, Meghan L. Marre, Jon D. Piganelli, Dana M. Previte, Hubert M. Tse, Greg M. Delgoffe
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 129-141.e4 (2019)
Summary: Lymphocyte activation gene-3 (LAG-3) is an inhibitory receptor expressed by CD4+ T cells and tempers their homeostatic expansion. Because CD4+ T cell proliferation is tightly coupled to bioenergetics, we investigate the role of LAG-3 in modu
Autor:
Janeth Yinh, Allen C. Steere, Meghan L. Marre, Shizuo Akira, Satoshi Uematsu, Linden T. Hu, Courtney T. Darcy
Publikováno v:
Infection and Immunity. 78:5307-5313
Borrelia burgdorferi stimulates a strong inflammatory response during infection of a mammalian host. To understand the mechanisms of immune regulation employed by the host to control this inflammatory response, we focused our studies on adrenomedulli
Publikováno v:
Infection and Immunity. 78:2584-2598
Yersinia spp. undermine the immune responses of infected animals by translocating Yops directly into host cells with a type III secretion system. YopM, a leucine-rich repeat protein, is a critical virulence factor in infection. YopM localizes to both
Autor:
Hai T Nguyen, David Arribas-Layton, I-Ting Chow, Carla Greenbaum, Meghan L. Marre, Jon D Piganelli, William Kwok, Eddie A James
Publikováno v:
The Journal of Immunology. 196:54.21-54.21
Selective recognition of self-proteins that have undergone enzymatic post-translational modification (PTM) by CD4+ T cells is increasingly implicated as a means of potentiating the loss of tolerance in autoimmune diseases such as type 1 diabetes (T1D
Publikováno v:
The Journal of Immunology. 196:124.49-124.49
Type 1 diabetes (T1D) is an autoimmune disease in which autoreactive T cells target and destroy pancreatic islet β cells. The key events that break peripheral tolerance in patients genetically predisposed to autoimmunity remain poorly understood. Ma
Autor:
Courtney T. Darcy, Alicia S. DeFrancesco, Linden T. Hu, Meghan L. Marre, Tanja Petnicki-Ocwieja
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12871 (2010)
PLoS ONE
PLoS ONE
Background: Toll-like receptor (TLR)-2/TLR1 heterodimers recognize bacterial lipopeptides and initiate the production of inflammatory mediators. Adaptors and co-receptors that mediate this process, as well as the mechanisms by which these adaptors an
Autor:
Dana M. Previte, Christina P. Martins, Erin C. O’Connor, Meghan L. Marre, Gina M. Coudriet, Noah W. Beck, Ashley V. Menk, Rebecca H. Wright, Hubert M. Tse, Greg M. Delgoffe, Jon D. Piganelli
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 129-141.e4 (2019)
Summary: Lymphocyte activation gene-3 (LAG-3) is an inhibitory receptor expressed by CD4+ T cells and tempers their homeostatic expansion. Because CD4+ T cell proliferation is tightly coupled to bioenergetics, we investigate the role of LAG-3 in modu
Externí odkaz:
https://doaj.org/article/5973900a5fa04fefa8bb32117570e50d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 3 (2015)
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by hyperglycemia due to progressive immune-mediated destruction of insulin-producing pancreatic islet β cells. Although many elegant studies have identified β cell autoantigens tha
Externí odkaz:
https://doaj.org/article/f754a0743bb9447b85a724f74c01f07e