Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Meghan J. Bloom"'
Autor:
Meghan J. Bloom, Angela M. Jarrett, Todd A. Triplett, Anum K. Syed, Tessa Davis, Thomas E. Yankeelov, Anna G. Sorace
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Therapy targeted to the human epidermal growth factor receptor type 2 (HER2) is used in combination with cytotoxic therapy in treatment of HER2+ breast cancer. Trastuzumab, a monoclonal antibody that targets HER2, has been shown p
Externí odkaz:
https://doaj.org/article/e4b25aa93b244549ae202f5975b1e3d2
Autor:
Thomas E. Yankeelov, Tessa Davis, Meghan J. Bloom, Angela M. Jarrett, Anum K. Syed, Todd A. Triplett, Anna G. Sorace
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
BMC Cancer
BMC Cancer
Background Therapy targeted to the human epidermal growth factor receptor type 2 (HER2) is used in combination with cytotoxic therapy in treatment of HER2+ breast cancer. Trastuzumab, a monoclonal antibody that targets HER2, has been shown pre-clinic
Publikováno v:
Cancer Research. 80:P1-18
Introduction: The purpose of this study is to quantify the effects of combination trastuzumab and radiation therapy in HER2+ breast cancer. Breast tumors can become hypoxic which increases radioresistance partly due to the upregulation of hypoxia ind
Autor:
Anum S. Kazerouni, David A. Hormuth, Tessa Davis, Meghan J. Bloom, Sarah Mounho, Gibraan Rahman, John Virostko, Thomas E. Yankeelov, Anna G. Sorace
Publikováno v:
Cancers; Volume 14; Issue 7; Pages: 1837
This study identifies physiological habitats using quantitative magnetic resonance imaging (MRI) to elucidate intertumoral differences and characterize microenvironmental response to targeted and cytotoxic therapy. BT-474 human epidermal growth facto
Autor:
Jianchen Yang, Yuan-I. Chen, Anum S. Kazerouni, Hsin-Chih Yeh, John Virostko, Thomas E. Yankeelov, Tessa Davis, Meghan J. Bloom
Publikováno v:
Mol Imaging Biol
PURPOSE: The reprogramming of cellular metabolism is a hallmark of cancer. The ability to noninvasively assay glucose and lactate concentrations in cancer cells would improve our understanding of the dynamic changes in metabolic activity accompanying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545a60d68537049305756243935caad6
https://europepmc.org/articles/PMC9302925/
https://europepmc.org/articles/PMC9302925/
Publikováno v:
Cancer Research. 79:P6-17
Introduction: We have previously established a tissue scale mathematical model with 5 coupled, ordinary differential equations (ODEs) describing the longitudinal relationship of vasculature, hypoxia, necrosis, immune infiltration, and tumor growth in
Publikováno v:
Cancers; Volume 14; Issue 17; Pages: 4234
Background: Trastuzumab induces cell cycle arrest in HER2-overexpressing cells and demonstrates potential in radiosensitizing cancer cells. The purpose of this study is to quantify combination trastuzumab and radiotherapy to determine their synergy.
Background: Trastuzumab, a clinical antibody targeted to the human epidermal growth factor receptor 2 (HER2), has been shown to sensitize cells to radiation in vitro. Current studies lack longitudinal evaluation of cellular response and in vivo data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2a87ac5e74bbcf402a66c35a821670
https://doi.org/10.21203/rs.3.rs-30208/v1
https://doi.org/10.21203/rs.3.rs-30208/v1
Autor:
Meghan J. Bloom, Angela M. Jarrett, Anna G. Sorace, Todd A. Triplett, Thomas E. Yankeelov, Anum K. Syed
Publikováno v:
Cancer Research. 79:P4-06
Introduction: The purpose of this study is to identify temporal changes in the identity and cellularity of myeloid cells infiltrating human epidermal growth factor receptor type 2 positive (HER2+) breast cancer following trastuzumab therapy. Trastuzu
Autor:
Yuan-I. Chen, Meghan J. Bloom, Anum S. Kazerouni, Tessa Davis, John Virostko, Jianchen Yang, Hsin-Chih Yeh, Thomas E. Yankeelov
Publikováno v:
Molecular Imaging and Biology. 24:156-156